NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
ALPHA-METHYLBENZYL ALCOHOL
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IDENTIFIERS
CATALOG ID NUMBER: 000600
CAS NUMBER: 98-85-1
BASE CHEMICAL NAME: METHYLBENZYLALCOHOL,A-
PRIMARY NAME: ALPHA-METHYLBENZYL ALCOHOL
CHEMICAL FORMULA: C8H10O
STRUCTURAL FORMULA: C6H5CH(CH3)OH
WLN: QY1&R
SYNONYMS:
ALPHA-METHYL-BENZENE METHANOL
METHYLPHENYLCARBINOL
METHYLPHENYL CARBINOL
1-PHENYL-ETHANOL
METHYLPHENYL METHANOL
ALPHA-METHYL-BENZYL ALCOHOL
ALPHA-PHENETHYL ALCOHOL
1-PHENYLETHANOL
PHENYLMETHYLCARBINOL
STYRALLYL ALCOHOL
STYRALYL ALCOHOL
1-PHENETHAN-1-OL
SEC-PHENETHYL ALCOHOL
BENZENEMETHANOL, ALPHA-METHYL-
NCI-C55685
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: LITERATURE: Colorless liquid
REPOSITORY: Colorless liquid
MOLECULAR WEIGHT: 122.17
SPECIFIC GRAVITY: 1.015 @ 20/4 C
DENSITY: 1.013 g/mL
MP (DEG C): 20 C
BP (DEG C): 204 C 745 mm Hg
SOLUBILITIES:
WATER : <1 mg/mL @ 19.5 C (RAD)
DMSO : >=100 mg/mL @ 19.5 C (RAD)
95% ETHANOL : >=100 mg/mL @ 19.5 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 19.5 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Glycerol: Soluble
Mineral oil: Soluble
ETHER : Miscible
VOLATILITY:
Vapor pressure: 0.1 mm Hg @ 20 C; 1 mm Hg @ 49.0 C; 5 mm Hg @ 75.2 C
Vapor density : 4.21
FLAMMABILITY(FLASH POINT):
The flash point for this chemical is 85 C (185 F) and it is combustible.
Fires involving this compound can be controlled using a dry chemical,
carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This compound is incompatible with strong oxidizing agents and strong acids.
STABILITY:
This compound congeals below room temperature. Solutions of this chemical
in water, DMSO, 95% ethanol and acetone should be stable for 24 hours under
normal lab conditions. (RAD)
OTHER PHYSICAL DATA:
Refractive index: 1.525-1.529 @ 20 C
Mild floral odor.
Freezing point: 21.4 C
TOXICITY
NIOSH REGISTRY NUMBER: DO9275000
TOXICITY:
typ. dose mode specie amount unit other
LD50 orl rat 400 mg/kg
LD50 skn rbt 2500 mg/kg
LD50 scu mus 250 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR = MODERATE skin irritant, SEVERE eye irritant in rabbit. HIGH via oral
and MODERATE via dermal routes.
CARCINOGENICITY:
Status: NTP Carcinogenesis Studies (Gavage); Some Evidence: Male Rat [620]
NTP Carcinogenesis Studies (Gavage); No Evidence: Female Rat, Male and
Female Mouse [620]
MUTATION DATA:
test lowest dose | test lowest dose
---------- ---------------- | ---------- -----------------
cyt-smc 5 mmol/tube |
TERATOGENICITY (Reproductive Effects Data): Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 0
Flammability (F): 2
Reactivity (R): 0
H0: Materials which on exposure under fire conditions would offer no
hazard beyond that of ordinary combustible material (see NFPA for
details).
F2: Materials which must be moderately heated before ignition will occur
(see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 10 mg/24H
skn-rbt 500 mg/24H MOD
eye-rbt 2 mg SEV
Standards and Regulations: DOT-IMO: Poison B; Label: St. Andrews Cross
Status: Reported in EPA TSCA Inventory, 1983
Meets criteria for proposed OSHA Medical Records Rule
EPA Genetic Toxicology Program, January 1984
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): alpha-Methylbenzyl alcohol
UN/ID NUMBER: UN2937
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 611, Y611 MAXIMUM QUANTITY: 60 L, 2 L
CARGO : PKG. INSTR.: 618 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
In flavors and perfumery; dyes; laboratory reagent.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is irritating to the skin, eyes, mucous membranes and the upper
respiratory tract. Exposure can cause damage to the eyes. When heated to de-
composition it emits toxic fumes.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemical:
Recommendations based on permeation test results are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): No information available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
Splash proof safety goggles should be worn while handling this
chemical. Alternatively, a full face respirator, equipped as above,
may be used to provide simultaneous eye and respiratory protection.
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and keep it away from oxidizing materials. STORE AWAY FROM SOURCES
OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include irritation of the eyes and
skin.
SOURCES
SOURCES:
Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 65th Ed. CRC Press, Inc. Boca Raton,
FL. 1984. p. C-446; #11252.
Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 527.
Boublik, T., V. Fried and E. Hala. The Vapor Pressures of Pure
Substances. p. 618.
Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. II, p. 93; #P01664.
Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-588; #P224.
Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 1447; #D.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1986. p. 1056; #P1,380-0.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 2158.
Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. p. 835.
National Fire Protection Association. Fire Protection Guide on
Hazardous Chemicals. 7th Ed. National Fire Protection
Association. Boston. 1978. p. 160; 325M.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 670.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 5, p. 4622; #P-01169.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. DO9275000.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 33.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
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