NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
2,2'-METHYLENEBIS(4-CHLOROPHENOL)
|
IDENTIFIERS
CATALOG ID NUMBER: 002078
CAS NUMBER: 97-23-4
BASE CHEMICAL NAME: METHYLENECHLOROPHENOL,2,2'-,BIS-,4-
PRIMARY NAME: 2,2'-METHYLENEBIS(4-CHLOROPHENOL)
CHEMICAL FORMULA: C13H10Cl2O2
STRUCTURAL FORMULA: CH2(C6H3(Cl)OH)2
WLN: QR DG B1R BQ EG
SYNONYMS:
PHENOL, 2,2'-METHYLENEBIS(4-CHLORO-
BIS(5-CHLORO-2-HYDROXYPHENYL)METHANE
BIS(2-HYDROXY-5-CHLOROPHENYL)METHANE
5,5'-DICHLORO-2,2'-DIHYDROXYDIPHENYLMETHANE
DI-(5-CHLORO-2-HYDROXYPHENYL)METHANE
2,2'-DIHYDROXY-5,5'-DICHLORODIPHENYLMETHANE
4,4'-DICHLORO-2,2'-METHYLENEDIPHENOL
2,2'-METHYLENEBIS(4-CHLOROPHENOL)
ANTHIPHEN
ANTIPHEN
DICHLOROPHEN
DIPHENTHANE 70
FUNGICIDE FX
HYOSAN
KORIUM
PANACIDE
PARABIS
PLATH-LYSE
PREVENTAL
PREVENTOL
PREVENTOL GD
PREVENTOL GDC
TAENIATOL
DIDROXANE
DIDROXAN
DICHLORPHEN
DICHLOROPHEN B
DICHLOROPHENE
DDDM
DDM
DICESTAL
TENIATHANE
TENIATOL
WESPURIL
G 4
GH
SUPER MOSSTOX
BIS(CHLOROHYDROXYPHENYL)METHANE
GEFIR
G 4 PURE
G 4 TECHNICAL
FUNGICIDE GM
FUNGICIDE M
DICHLOROFEN
ANTIFEN
DIFENTAN
TENIOTOL
GINGIVIT
CORDOCEL
HALENOL
VERMITHANA
EMBEPHEN
PALACEL
PREVENTOL
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White or slightly cream-colored powder
REPOSITORY: Light pink powder
MOLECULAR WEIGHT: 269.13
SPECIFIC GRAVITY: Not available
DENSITY: Not available
MP (DEG C): 177-178 C [016,031,055,169]
BP (DEG C): Not available
SOLUBILITIES:
WATER : <1 mg/mL @ 22 C (RAD)
DMSO : >=100 mg/mL @ 22 C (RAD)
95% ETHANOL : >=100 mg/mL @ 22 C (RAD)
METHANOL : Soluble [031,169]
ACETONE : >=100 mg/mL @ 22 C (RAD)
TOLUENE : Sparingly soluble [029,031,169]
OTHER SOLVENTS:
Alcohol: 1 in 1 @ 20 C [295,455]
Carbon tetrachloride: Slightly soluble [062]
Isopropyl ether: Soluble [031,169]
Petroleum ether: Soluble [031,169,205]
Benzene: Slightly soluble [062]
Alkaline aqueous solutions: Soluble (with decomposition) [031]
Ether: 1 in <1 @ 20 C [031,295,455]
VOLATILITY:
Vapor pressure: 0.0000000001 mm Hg @ 25 C [062]; 0.0001 mm Hg @ 100 C [043]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also
be used [269].
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong oxidizing agents and strong
bases [269].
STABILITY:
This chemical is slowly oxidized in air [169]. Solutions of this
chemical in water, DMSO, 95% ethanol or acetone should be stable for 24
hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Slight phenolic odor [062,172,295,455]
Technical grade is a light tan powder [172]
Melting point also reported as 168-172 C [269,275]
Saline and phenolic taste [295,455]
Acidic [172]
pK1: 7.6 [172]
pK2: 11.6 [172]
UV max (in 0.1N sodium hydroxide): 245 nm, 304 nm (E = 650, 270) [455]
TOXICITY
NIOSH REGISTRY NUMBER: SM0175000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 1506 mg/kg
LD50 ivn rat 17 mg/kg
LD50 orl mus 1 gm/kg
LD50 orl dog 2000 mg/kg
LD50 orl gpg 1250 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by intravenous route. Moderately toxic by ingestion. A skin
and severe eye irritant. Mutation data.
CARCINOGENICITY: Not available
MUTATION DATA: See RTECS printout for data
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 500 mg/24H MLD
eye-rbt 50 ug/24H SEV
Status: EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, September, 1989
Fatal dose: 10 g [301]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This compound is an anthelmintic used in the treatment of infection by
tapeworms (dwarf tapeworm, pork tapeworm). It is also used as a fungicide,
germicide in soap and shampoo, herbicide, bactericide, antimicrobial (anti-
protozoan) and algicide. It is used to control moss in turf and is the basis
of a preparation against athlete's foot. In veterinary medicine it is used
to remove ascarids and hookworms and to treat ringworm. It also has some
dermatological and cosmetic applications.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by ingestion [062]. It is an irritant [029].
When heated to decomposition it emits toxic fumes of carbon monoxide, carbon
dioxide and hydrogen chloride gas [043,269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Viton North F-091 0.25 mm 240 min
PVA Edmont 25-545 0.23 mm 360 min
Nitrile Surety rubber nitrile 0.20 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should keep this material in a tightly closed container
under an inert atmosphere, and store it at refrigerated temperatures.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include sensitivity dermatitis,
photosensitivity and stomatitis [301]. Other symptoms include nausea,
vomiting, gastrointestinal colic, diarrhea, urticarial rash and jaundice
[295]. Irritation of the skin, eyes, mucous membranes and upper respiratory
tract may also occur [269]. It can cause cramps [043].
Symptoms of exposure to related compounds include necrosis of the
mucous membranes, cerebral edema, degenerative changes in the liver and
kidneys, bladder necrosis, collapse, coma, painless blanching or erythema,
possible corrosion, profuse sweating, intense thirst, cyanosis from methemo-
globinemia, hyperactivity, stupor, blood pressure fall, hyperpnea, abdominal
pain, hemolysis, convulsions and pulmonary edema followed by pneumonia. If
death from respiratory failure is not immediate, oliguria or anuria may occur
[301].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. SM0175000.
February 1, 1990.
[016] Weast, R.C., D.R. Lide, M.J. Astle, and W.H. Beyer, Eds. CRC Handbook
of Chemistry and Physics. 70th Ed. CRC Press, Inc. Boca Raton,
FL. 1989. p. C-251, #6293.
[029] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed. and
Supplements. Chapman and Hall. New York. 1988. Vol. 2, p. 1767,
#D-03049.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 446, #3056.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. III, p. 2304, #MJM500.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 575, #D00718.
[055] Verschueren, K. 0andbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
pp. 484-485.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 380.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[141] Veterinary Medicine Publishing Co. Veterinary Pharmaceuticals
and Biologicals. 6th Ed. Veterinary Medicine Publishing Co.
Lenexa, KS. 1988. p. 789.
[151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. pp. II-194 to II-195, #529.
[165] Wiswesser, W.J., Ed. Pesticide Index. Entomological Society
of America. College Park, MD. 1976. p. 75.
[169] Hartley, Douglas B.Sc., Ph.D., M.I.Inf.Sc. and Hamish Kidd B.Sc., Eds.
The Agrochemicals Handbook. 2nd Ed. The Royal Society of Chemistry.
Nottingham, England. 1987. Listed.
[172] Worthing, C.R., Ed. The Pesticide Manual, A World Compendium.
8th Ed. British Crop Protection Council. London, England.
1987. p. 260.
[186] Sittig, Marshall, Ed. Pesticide Manufacturing and Toxic Materials
Control Encyclopedia. Noyes Data Corporation. Park Ridge, NJ.
1980. pp. 285-286.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-509, #m434.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 1245, #D.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 1011, #13,322-1.
[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
The Pharmaceutical Press. London. 1982. p. 90, #771-e.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. pp. 402-403.
[455] The Pharmaceutical Society of Great Britain. The Pharmaceutical Codex.
11th Edition. The Pharmaceutical Press. London. 1979. pp. 273-
274.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 32.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
-------------------------------------------------------------