NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001443
CAS NUMBER: 96-24-2
BASE CHEMICAL NAME: CHLOROPROPANEDIOL,3-,1,2-
PRIMARY NAME: 3-CHLORO-1,2-PROPANEDIOL
CHEMICAL FORMULA: C3H7ClO2
STRUCTURAL FORMULA:
WLN: Q1YQ1G
SYNONYMS:
ALPHA-CHLORHYDRIN
CHLORODEOXYGLYCEROL
1-CHLORO-2,3-DIHYDROXYPROPANE
3-CHLORO-1,2-DIHYDROXYPROPANE
ALPHA-CHLOROHYDRIN
1-CHLOROPROPANE-2,3-DIOL
1-CHLORO-2,3-PROPANEDIOL
3-CHLOROPROPANE-1,2-DIOL
3-CHLORO-1,2-PROPANEDIOL
3-CHLOROPROPYLENE GLYCOL
2,3-DIHYDROXYPROPYL CHLORIDE
GLYCERINE ALPHA-MONOCHLOROHYDRIN
GLYCEROL CHLOROHYDRIN
MONOCHLORHYDRIN
U-5897
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: LITERATURE: Colorless liquid
REPOSITORY: Light yellow viscous liquid
MOLECULAR WEIGHT: 110.54
SPECIFIC GRAVITY: 1.326 @ 18/15 C
DENSITY: Not available
MP (DEG C): -40 C
BP (DEG C): 213 C (decomposes)
SOLUBILITIES:
WATER : >=100 mg/mL @ 21 C (RAD)
DMSO : >=100 mg/mL @ 21 C (RAD)
95% ETHANOL : >=100 mg/mL @ 21 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 21 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Oils: Immiscible
ETHER : Soluble
VOLATILITY:
Vapor pressure: 3.75 mm Hg @ 25 C
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
The flash point for this compound is 58 C (138 F), and it is combustible.
Fires involving this compound can be controlled using a dry chemical, carbon
dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
Glycols and their ethers undergo violent decomposition in contact with
approximately 70% perchloric acid.
STABILITY:
This compound is hygroscopic and may be sensitive to prolonged exposure to air.
OTHER PHYSICAL DATA:
Refractive Index: 1.4809 @ 20 C; 1.4784 @ 20 C
(R)-form: Optical rotation: -6.09 @ 20 C in H2O
(S)-form: Boiling point: 80 C @ 0.5 mm Hg
Optical rotation: +7.3 @ 20 C in H2O
(+/-)-form: Liquid with sweet taste.
Boiling point: 139 C @ 18 mm Hg
Viscosity: 2.388 poise @ 20 C
This compound has a tendency to turn straw colored.
TOXICITY
NIOSH REGISTRY NUMBER: TY4025000
TOXICITY:
typ. dose mode specie amount unit other
LD50 orl rat 26 mg/kg
LCLo ihl rat 125 ppm/4H
LDLo ipr rat 10 mg/kg
LD50 orl mus 160 mg/kg
LD50 ipr mus 73 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: MUTATION data. An eye irritant. HIGH oral, inhalation, intraperitoneal.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 34580 mg/kg/72W-C
MUTATION DATA:
test lowest dose test lowest dose
---------- ---------------- | ---------- ----------------
mmo-sat 200 umol/plate | mma-sat 200 umol/plate
mma-ssp 300 mmol/L | mmo-ssp 100 mmol/L
spm-rat-orl 600 mg/kg/24D-C | msc-mus:lym 10 mmol/L
spm-rat-scu 40 mg/kg |
TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-rat 2500 ug/kg (1D male)
TDLo: orl-rat 2 mg/kg (1D male)
TDLo: orl-rat 85500 ug/kg (9D male)
TDLo: ipr-rat 13200 ug/kg (3D male)
TDLo: ipr-rat 150 mg/kg (10D male)
TDLo: scu-rat 14 mg/kg (1D male)
TDLo: scu-rat 90 mg/kg (1D male)
TDLo: ipr-mus 133 mg/kg (3D male)
TDLo: scu-dog 240 mg/kg (30D male)
TDLo: scu-dog 70 mg/kg (1D male)
TDLo: orl-mky 1260 mg/kg (42D male)
TDLo: orl-mky 5600 mg/kg (40D male)
TDLo: itt-mky 40 mg/kg (1D male)
TDLo: orl-ctl 450 mg/kg (18D male)
TDLo: ims-ctl 75 mg/kg (3D male)
TDLo: scu-rat 24 mg/kg (3D male)
TDLo: scu-rat 750 mg/kg (15D pre)
TDLo: itt-dog 2667 ug/kg (1D male)
TDLo: itt-dog 15385 ug/kg (1D male)
TDLo: scu-rbt 24 mg/kg (3D male)
TDLo: orl-pig 25 mg/kg (25D male)
TDLo: orl-pig 5 mg/kg (5D male)
TDLo: orl-ham 350 mg/kg (7D male)
TDLo: orl-ham 280 mg/kg (7D male)
TDLo: scu-ham 132 mg/kg (2D male)
TDLo: orl-grb 750 mg/kg (50D male)
TDLo: orl-dom 625 mg/kg (25D male)
TDLo: ims-dom 75 mg/kg (3D male)
TDLo: scu-rat 150 mg/kg (10D male)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-rbt 27 mg
Review: Toxicology Review
Standards and Regulations: DOT-IMO: Poison B; Label: St. Andrews Cross
Status: Reported in EPA TSCA Inventory, 1983
Meets criteria for proposed OSHA Medical Records Rule
EPA Genetic Toxicology Program, January 1984
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Glycerol alpha-monochlorohydrin
UN/ID NUMBER: UN2689
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 611, Y611 MAXIMUM QUANTITY: 60 L, 2 L
CARGO : PKG. INSTR.: 618 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
Used to lower the freezing point in dynamite; in the manufacture of dye
intermediates; as a solvent for cellulose acetate, glyceryl phthalate resins
and as a partial solvent for gums; organic synthesis; and a rodent chemo-
sterilant.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is a moderate skin and eye irritant. It is toxic by ingestion
and inhalation and can be absorbed by the skin. When heated to decomposition
it emits toxic fumes.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemical:
Recommendations based on permeation test results are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): No information available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER: Not available
STORAGE PRECAUTIONS:
You should keep this material in a tightly closed container
under an inert atmosphere, and store it at refrigerated temperatures.
STORE AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Seal the absorbent
paper, as well as any of your clothing which may be contaminated, in a vapor-
tight plastic bag for eventual disposal. Wash any surfaces you may have
contaminated with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center.
Generally, the induction of vomiting is NOT recommended outside of a
physician's care due to the risk of aspirating the chemical into the victim's
lungs. However, if the victim is conscious and not convulsing and if medical
help is not readily available, consider the risk of inducing vomiting because
of the high toxicity of the chemical ingested. Ipecac syrup or salt water may
be used in such an emergency. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include eye and nasal irritation,
nausea, vomiting, giddiness, dizziness, incoordination, and coma. Chronic
exposure can cause nausea, vomiting and abdominal pain.
SOURCES
SOURCES:
Hazards Research Corporation. Vapor Pressure Determinations for
Fifteen Materials: HRC Report 5913D. August 14, 1985.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 672.
Weiss, G., Ed. Hazardous Chemicals Data Book. Noyes Data
Corporation. Park Ridge, NJ. 1980. p. 1005.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1984. p. 273; #23,618-7.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 237.
Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 301; #2115.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 1, p. 1200; #C-02156.
Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry
and Physics. 63rd Ed. CRC Press, Inc. Boca Raton, FL.
1982. p. C-467; #11901.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. TY4025000.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 31.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. October 3, 1990.
Listed.
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