NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
1,2-DIBROMO-3-CHLOROPROPANE
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IDENTIFIERS
CATALOG ID NUMBER: 000293
CAS NUMBER: 96-12-8
BASE CHEMICAL NAME: DIBROMOCHLOROPROPANE,1,2-,3-
PRIMARY NAME: 1,2-DIBROMO-3-CHLOROPROPANE
CHEMICAL FORMULA: C3H5Br2Cl
STRUCTURAL FORMULA: BrCH2CH(Br)CH2Cl
WLN: G1YE1E
SYNONYMS:
3-CHLORO-1,2-DIBROMOPROPANE
DIBROMOCHLOROPROPANE
1-CHLORO-2,3-DIBROMOPROPANE
FUMAGON
BBC 12
DBCP
FUMAZONE
FUMAZONE 86
FUMAZONE 86E
NEMABROM
NEMAFUME
NEMAGON
NEMAGON SOIL FUMIGANT
NEMANAX
NEMASET
OS 1897
SD 1897
NEMAGON 20
NEMAGON 20G
NEMAGON 90
NEMAGON 206
NEMAPAZ
NEMATOCIDE
NEMATOX
NEMAZON
NEMAGONE
OXY DBCP
NCI-C00500
RCRA WASTE NUMBER U066
UN 2872
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Amber to colorless liquid
REPOSITORY: Clear, slightly yellow liquid
MOLECULAR WEIGHT: 236.35
SPECIFIC GRAVITY: 2.08 @ 20/20 C [055,395]
DENSITY: 2.05 g/mL @ 20 C [051,062]
MP (DEG C): 6 C [107,327]
BP (DEG C): 196 C [031,047,395,430]
SOLUBILITIES:
WATER : <0.1 mg/mL @ 18 C (RAD)
DMSO : >=100 mg/mL @ 20 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20 C (RAD)
METHANOL : Miscible [173,395]
ACETONE : >=100 mg/mL @ 20 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Dichloropropane: Miscible [031,173]
Oils: Miscible [031,051,062,205]
Isopropyl alcohol: Miscible [031,173,395]
Liquid hydrocarbons: Miscible [395]
Halogenated hydrocarbons: Miscible [395]
Alcohols: Soluble [430]
VOLATILITY:
Vapor pressure: 0.8 mm Hg @ 21 C [031,055,173,395]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 76.6 C (170 F) [043,051,062,107]. It
is combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical reacts with chemically active metals such as aluminum,
magnesium, tin and their alloys [173,327]. It will attack some rubber
materials and coatings [327,395].
STABILITY:
This chemical is stable under normal laboratory conditions. It is stable
in neutral and acidic media. It is hydrolyzed in alkali [173,395]. Solutions
of this chemical in water, DMSO, 95% ethanol or acetone should be stable for
24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Pungent odor [031,173,327,395]
Refractive index: 1.5518 @ 25 C [395,430]; 1.553 @ 14 C [031,047,205]
Boiling point: 78 C @ 16 mm Hg [031,047]; 21 C @ 0.8 mm Hg [025,031]
Specific gravity: 2.09 @ 20/4 C [430]
Density: 2.093 g/mL @ 14 C [031,047,205]
Freezing point: 6.7 C [062]
Evaporation rate (butyl acetate = 1): Very much less than 1 [327]
TOXICITY
NIOSH REGISTRY NUMBER: TX8750000
TOXICITY:
typ. dose mode specie amount units other
LD50 scu rat 100 mg/kg
LD50 orl rat 170 mg/kg
LC50 ihl rat 103 ppm/8H
LD50 orl mus 257 mg/kg
LD50 orl rbt 180 mg/kg
LD50 skn rbt 1400 mg/kg
LD50 orl gpg 150 mg/kg
LD50 orl ckn 60 mg/kg
LD50 ipr mus 123 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion, inhalation and subcutaneous routes. Moderately
toxic by skin contact. An eye and severe skin irritant. An experimental
carcinogen and teratogen. A suspected human carcinogen. Narcotic in
high concentrations. It has been implicated in causing human male
sterility in factory workers. Human mutagenic data. A soil fumigant.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 5475 mg/kg/73W-I
TCLo: ihl-rat 600 ppb/6H/2Y-I
TDLo: orl-mus 49 gm/kg/47W-I
TCLo: ihl-mus 600 ppb/6H/2Y-I
TDLo: skn-mus 100 gm/kg/74W-I
TD : orl-rat 9280 mg/kg/64W-I
TC : ihl-mus 3 ppm/6H/2Y-I
TC : ihl-rat 3 ppm/6H/2Y-I
TC : ihl-rat 600 ppb/6H/2Y-I
TC : ihl-rat 3 ppm/6H/84W-I
TC : ihl-mus 600 ppb/6H/2Y-I
TC : ihl-mus 3 ppm/6H/76W-I
TC : ihl-mus 600 ppb/6H/76W-I
TC : ihl-rat 600 ppb/6H/76W-I
TDLo: scu-rat 240 mg/kg/12W-I
TD : scu-rat 240 mg/kg/12W-I
Review: IARC Cancer Review: Animal Sufficient Evidence
IARC Cancer Review: Human Inadequate Evidence
IARC possible human carcinogen (Group 2B) [395,610]
Standards and Regulations: OSHA cancer hazard [015,327,610]
Status: NCI Carcinogenesis Bioassay (Gavage); Positive: Male and Female Rat,
Male and Female Mouse [620]
NTP Carcinogenesis Bioassay (Inhalation); Positive: Male and Female
Rat, Male and Female Mouse [620]
NTP Fourth Annual Report on Carcinogens, 1984
NTP anticipated human carcinogen [610]
EPA Carcinogen Assessment Group [610]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mmo-sat 10 nL/plate | dlt-rat-orl 50 mg/kg/5D-C
mma-sat 500 ng/plate | dns-mus-ipr 100 mg/kg
dnr-esc 20900 ug/disc | sce-ham:lng 500 umol/L
mmo-bcs 1 nmol/plate | sln-dmg-ihl 17700 ppb/3H-C
dnd-rat:lvr 30 umol/L | dni-hmn:hla 10 mmol/L
cyt-rat-orl 3650 ug/kg/5D | spm-rat-orl 3650 ug/kg/5D
sln-dmg-orl 100 ppm/3D | trn-dmg-orl 200 ppm
dnd-rat-ipr 35 mg/kg | dnd-rat:tes 173 mg/L
spm-rbt-orl 375 mg/kg/10W-I | dns-mus-ipr 100 mg/kg
cyt-ham:lng 200 umol/L | dns-rat-ipr 150 mg/kg
msc-mus:lym 83700 ug/L | cyt-ham:ovr 50 mg/L
sce-ham:ovr 10 mg/L |
TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-rat 500 mg/kg (6-15D preg)
TDLo: orl-rat 250 mg/kg (5D male)
TDLo: orl-rat 50 mg/kg (5D male)
TCLo: ihl-rat 10 ppm/6H (4W male)
TCLo: ihl-rat 1 ppm/6H (4W male)
TCLo: ihl-rat 10 ppm/7H (50D male)
TCLo: ihl-rbt 1 ppm/6H (70D male)
TCLo: ihl-rbt 10 ppm/6H (40D male)
TCLo: ihl-rbt 12 ppm/7H (66D male)
TCLo: ihl-gpg 12 ppm/7H (66D male)
TDLo: unr-rat 100 mg/kg (1D male)
TDLo: orl-rat 200 mg/kg (1D male)
TDLo: orl-rat 375 mg/kg (75D male)
TDLo: scu-rat 80 mg/kg (1D male)
TDLo: scu-rat 33 mg/kg (1D male)
TDLo: scu-rat 19 mg/kg (19D male)
TDLo: scu-rat 40 mg/kg (1D male)
TDLo: orl-rbt 92657 ug/kg (10W male)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910
PEL-TWA 1 ppm; eye and skin contact prohibited [327,545,610]
ACGIH: None
NIOSH Criteria Document: Recommended exposure limit to this compound-air:
Ceiling Limit 0.01 ppm/30M [015]
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 10 gm SEV
eye-rbt 1% MLD
Review: Toxicology Review
Standards and Regulations: DOT-IMO: Poison B; Label: St. Andrew's Cross
Status: EPA TSCA Chemical Inventory, 1986
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
EPA TSCA Section 8(e) Status Report 8EHQ-0877-0003
EPA TSCA Section 8(e) Status Report 8EHQ-0278-0056
EPA TSCA Section 8(e) Status Report 8EHQ-0378-01138
EPA TSCA Section 8(e) Status Report 8EHQ-0478-0123
EPA TSCA Section 8(e) Status Report 8EHQ-0478-0128
EPA TSCA Section 8(e) Status Report 8EHQ-0678-0192 S
EPA TSCA Section 8(e) Status Report 8EHQ-0778-0219
Meets criteria for proposed OSHA Medical Records Rule
EPA Genetox Program 1988, Positive: Carcinogenicity-mouse/rat; E coli
polA without S9
EPA Genetox Program 1988, Positive: Histidine reversion-Ames test;
Sperm morphology-human
EPA TSCA Test Submission (TSCATS) Data Base, June 1988
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Dibromochloropropanes
UN/ID NUMBER: UN2872
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 611, Y611 MAXIMUM QUANTITY: 60 L, 2 L
CARGO : PKG. INSTR.: 618 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
This compound is used as a soil fumigant, nematocide, pesticide and
intermediate in organic synthesis.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is highly toxic via all routes [107]. It is an eye and
severe skin irritant [043]. It is also an irritant of the mucous membranes
[031]. It is narcotic in high concentrations [031,043]. When heated to
decomposition it emits toxic fumes of hydrogen bromide, hydrogen chloride
and carbon monoxide [043,326].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Viton/Nitrile North Vitrile 0.20 mm 480 min
RECOMMENDED RESPIRATOR:
When working with this chemical, wear a NIOSH-approved full face
positive pressure supplied-air respirator or a self-contained breathing
apparatus (SCBA). [651]
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this material at ambient temperatures.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center.
Generally, the induction of vomiting is NOT recommended outside of a
physician's care due to the risk of aspirating the chemical into the victim's
lungs. However, if the victim is conscious and not convulsing and if medical
help is not readily available, consider the risk of inducing vomiting because
of the high toxicity of the chemical ingested. Ipecac syrup or salt water may
be used in such an emergency. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
This compound is an eye and severe skin irritant [043]. It is also an
irritant of the mucous membranes [031]. It is narcotic in high concentrations
[031,043]. It has been implicated in sterility in males [043,062,186,395].
It may also cause diminished renal function and degeneration and cirrhosis of
the liver [186]. Other symptoms include nausea, conjunctivitis, respiratory
irritation, pulmonary congestion, pulmonary edema, central nervous system
depression, apathy, sluggishness and ataxia. Upon repeated exposure, ery-
thema, inflammation and dermatitis may occur [327]. Exposure may also cause
drowsiness, vomiting, liver and kidney damage, respiratory distress, testicular
atrophy, spleen necrosis and sperm count depression [107].
SOURCES
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