NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000624
CAS NUMBER: 95-79-4
BASE CHEMICAL NAME: CHLOROTOLUIDINE,5-,O-
PRIMARY NAME: 5-CHLORO-O-TOLUIDINE
CHEMICAL FORMULA: C7H8ClN
STRUCTURAL FORMULA: ClC6H3(CH3)NH2
WLN: ZR CG F1
SYNONYMS:
1-AMINO-3-CHLORO-6-METHYLBENZENE
2-AMINO-4-CHLOROTOLUENE
4-CHLORO-2-AMINOTOLUENE
3-CHLORO-6-METHYLANILINE
5-CHLORO-2-METHYLANILINE
5-CHLORO-2-METHYLBENZENAMINE
ACCO FAST RED KB BASE
ANSIBASE RED KB
AZOIC DIAZO COMPONENT 32
AZOENE FAST RED KB BASE
FAST RED KB AMINE
FAST RED KB BASE
FAST RED KB SALT
FAST RED KB SALT SUPRA
FAST RED KBS SALT
GENAZO RED KB SOLN
HILTONIL FAST RED KB BASE
LAKE RED BK BASE
METROGEN RED FORMER KB SOLN
NAPHTHOSOL FAST RED KB BASE
NCI-C02051
PHARMAZOID RED KB
RED KB BASE
SPECTROLENE RED KB
STABLE RED KB BASE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Off-white solid or light brown oil
REPOSITORY: Brown solid; brown liquid (after melting)
MOLECULAR WEIGHT: 141.60
SPECIFIC GRAVITY: >1.1 @ 20 C [371]
DENSITY: Not available
MP (DEG C): 22 C [205,269,275]
BP (DEG C): 241 C [043,055,371]
SOLUBILITIES:
WATER : <1 mg/mL @ 20 C (RAD)
DMSO : >=100 mg/mL @ 22 C (RAD)
95% ETHANOL : >=100 mg/mL @ 22 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 22 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Soluble [017]
VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 160 C (320 F) [205,269,275]. It is
combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. A water spray may also be
used [371].
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with acids, acid chlorides, acid anhydrides,
chloroformates and strong oxidizing agents [269].
STABILITY:
This chemical may be sensitive to prolonged exposure to air and light.
NMR stability screening indicates that solutions of this chemical in DMSO
are stable for at least 24 hours (RAD).
OTHER PHYSICAL DATA:
Refractive index: 1.5840 @ 20 C [205,269,275]
Boiling point: 140 C @ 38 mm Hg; 237 C @ 722 mm Hg [017,047]
Weak fishy odor [371]
Sinks in water [371]
Freezing point: 25 C [371]
TOXICITY
NIOSH REGISTRY NUMBER: XU5075000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 464 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: An experimental carcinogen and tumorigen. Moderately toxic by ingestion.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 164 gm/kg/78W-C
TDLo: orl-mus 131 gm/kg/78W-C
TD : orl-mus 262 gm/kg/78W-C
Status: NCI Carcinogenesis Bioassay (Feed); Negative: Male and Female Rat
[620]
NCI Carcinogenesis Bioassay (Feed); Positive: Male and Female Mouse
[620]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
dni-mus-orl 200 mg/kg |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Status: EPA TSCA Chemical Inventory, 1986
EPA Genetox Program 1986, Negative: Sperm morphology-mouse
EPA Genetox Program 1986, Positive/Limited: Carcinogenicity-mouse/rat
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Chlorotoluidines, liquid
UN/ID NUMBER: UN2239
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 611, Y611 MAXIMUM QUANTITY: 60 L, 2 L
CARGO : PKG. INSTR.: 618 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
This compound is used as a chemical intermediate.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by inhalation and ingestion [062]. It is an
irritant of the skin and eyes, and it may be absorbed through the skin [269].
It may cause bladder irritation [301]. When heated to decomposition it emits
very toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides and
hydrogen chloride gas [043,269].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-161 0.40 mm 240 min
Unknown North Silvershield 0.10 mm 240 min
Neoprene Pioneer N-44 0.56 mm 240 min
PVA Edmont 25-950 0.33 mm 480 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should protect this chemical from exposure to light. Keep
the container tightly closed under an inert atmosphere, and store
under refrigerated temperatures.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include cyanosis and irritation
of the skin and eyes [269]. It may also cause methemoglobinemia and bladder
irritation [301]. Other symptoms may include headache, drowsiness, nausea and
a bluish tint in the fingernails, lips and ears [371].
SOURCES
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of Chemical Substances. Microfiche Ed. National Institute for
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[017] Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 67th Ed. CRC Press, Inc. Boca Raton,
FL. 1986. p. C-526, #14313.
[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 1, p. 1133, #C-01462.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
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Vol. II, pp. 170-171, #AJJOOO.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
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[055] Verschueren, K. Handbook of Environmental Data on Organic
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p. 388.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
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pp. 56-57.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
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[105] The Society of Dyers and Colourists. Colour Index. Vols. 1-7.
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American Association of Textile Chemists and Colorists.
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[110] Oak Ridge National Laboratory. Environmental Mutagen Information
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[120] Oak Ridge National Laboratory. Environmental Teratogen Information
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[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-218, #c283.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 414, #B.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
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1988. p. 350, #C5,120-2.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. p. 154.
[371] U.S. Coast Guard, Department of Transportation. CHRIS
Hazardous Chemical Data. U.S. Coast Guard. Washington,
D.C. 1985. Listed.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
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[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. October 3, 1990.
Listed.
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