NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000936
CAS NUMBER: 933-78-8
BASE CHEMICAL NAME: TRICHLOROPHENOL,2,3,5-
PRIMARY NAME: 2,3,5-TRICHLOROPHENOL
CHEMICAL FORMULA: C6H3Cl3O
STRUCTURAL FORMULA: Cl3C6H2OH
WLN: QR BG CG EG
SYNONYMS:
PHENOL, 2,3,5-TRICHLORO-
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Long colorless needles
REPOSITORY: White chalky solid
MOLECULAR WEIGHT: 197.45
SPECIFIC GRAVITY: Not available
DENSITY: Not available
MP (DEG C): 57-59 C [205,269,275]
BP (DEG C): 248-249 C [016,205,269,275]
SOLUBILITIES:
WATER : <1 mg/mL @ 16 C (RAD)
DMSO : >=100 mg/mL @ 16 C (RAD)
95% ETHANOL : >=100 mg/mL @ 16 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 16 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Soluble [016,205]
Ether: Soluble [016,047,205]
Ligroin: Soluble [029]
VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with acid chlorides, acid anhydrides and
oxidizing agents [269].
STABILITY:
This chemical is very hygroscopic [029]. Solutions of this chemical in
water, DMSO, 95% ethanol or acetone should be stable for 24 hours under
normal lab conditions (RAD).
OTHER PHYSICAL DATA: Not available
TOXICITY
NIOSH REGISTRY NUMBER: Not available
TOXICITY:
typ. dose mode specie amount units other
Not available
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Not available
CARCINOGENICITY: Not available
MUTATION DATA: Not available
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Fatal dose for chlorophenols is 5 grams [301]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Chlorophenols, solid
UN/ID NUMBER: UN2020
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 619, Y619 MAXIMUM QUANTITY: 100 kg, 10 kg
CARGO : PKG. INSTR.: 619 MAXIMUM QUANTITY: 200 kg
SPECIAL PROVISIONS: None
USES: Not available
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may be harmful by ingestion. It is an irritant of the skin,
eyes, mucous membranes and upper respiratory tract. Prolonged contact may
result in severe burns and destruction of tissue. When heated to decomposition
it emits toxic fumes of carbon monoxide, carbon dioxide and hydrogen chloride
gas [269].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Viton North F-091 0.25 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
Splash proof safety goggles should be worn while handling this
chemical. Alternatively, a full face respirator, equipped as above,
may be used to provide simultaneous eye and respiratory protection.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and protect it from moisture. If possible, it would be prudent to
store this compound under inert atmosphere.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Phenols are very toxic poisons AND corrosive
and irritating, so that inducing vomiting may make medical problems worse.
IMMEDIATELY call a hospital or poison control center and locate activated
charcoal, egg whites, or milk in case the medical advisor recommends admini-
stering one of them.
If advice from a physician is not readily available and the victim is
conscious and not convulsing, give the victim a glass of activated charcoal
slurry in water or, if this is not available, a glass of milk, or beaten egg
whites and IMMEDIATELY transport victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
assure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include painless blanching or
erythema, vomiting, collapse, coma, profuse sweating, intense thirst, nausea,
diarrhea, cyanosis, hyperactivity, stupor, blood pressure fall, hyperpnea,
abdominal pain, hemolysis, convulsions and pulmonary edema followed by pneu-
monia [301]. Other symptoms include irritation of the skin with redness and
edema, burns, irritation of the eyes, nose and pharynx, and corneal injury
[151]. Exposure can cause irritation of the mucous membranes and respiratory
tract, and severe destruction of tissue (depending on the intensity and dura-
tion of exposure) [269].
Symptoms of exposure to a related compound include softening and whitening
of the skin followed by the development of painful burns, headache, dizziness,
rapid and difficult breathing and weakness. Ingestion of a related compound
causes severe burns and internal damage. Chronic exposure may cause digestive
disturbances, nervous disorders, skin eruptions, dermatitis, liver damage and
kidney damage [036]. Skin contact may result in redness, edema and burns. Eye
contact may cause irritation and corneal injury [151].
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