NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000575
CAS NUMBER: 90-43-7
BASE CHEMICAL NAME: PHENYLPHENOL,O-
PRIMARY NAME: O-PHENYLPHENOL
CHEMICAL FORMULA: C12H10O
STRUCTURAL FORMULA:
WLN: QR BR
SYNONYMS:
(1,1'-BIPHENYL)-2-OL
2-BIPHENYLOL
O-BIPHENYLOL
2-DIPHENYLOL
2-HYDROXYBIPHENYL
O-DIPHENYLOL
DOWICIDE 1
DOWCIDE 1
O-HYDROXYBIPHENYL
O-HYDROXYDIPHENYL
NCI-C50351
2-PHENYLPHENOL
ORTHOHYDROXYDIPBENYL
ORTHOPHENYLPHENOL
ORTHOXENOL
TORSITE
USAF EK-2219
O-XENOL
2-HYDROXYDIPHENYL
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: Literature: Light purple colored crystals.
Repository: Light lavender crystalline solid.
MOLECULAR WEIGHT: 170.21
SPECIFIC GRAVITY: 1.213 @ 25/4 C
DENSITY:Not available
MP (DEG C): 55.5 - 57.5 C
BP (DEG C): 275 C
SOLUBILITIES:
WATER : <0.1 mg/mL @ 20.5 C (RAD)
DMSO : >=100 mg/mL @ 22 C (RAD)
95% ETHANOL : >=100 mg/mL @ 22 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 22 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Ligroin: Soluble
Fixed Alkali Hydroxide Solution: Soluble
ETHER : Soluble
BENZENE: Soluble
VOLATILITY : Vapor pressure: 1 mm Hg @ 100 C
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 124 C (255 F). It is combustible. Fires
involving this chemical can be controlled with a dry chemical, carbon dioxide,
foam or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY: This compound can react with oxidizing materials.
STABILITY: This chemical is stable under normal laboratory conditions.
OTHER PHYSICAL DATA:
Boiling point: 145 C @ 14 mm Hg
Volatile in steam
TOXICITY
NIOSH REGISTRY NUMBER: DV5775000
TOXICITY:
typ. dose mode specie amount unit other
LD50 orl rat 2000 mg/kg
LD50 unk rat 2700 mg/kg
LD50 orl mus 900 mg/kg
LD50 ipr mus 50 mg/kg
LD50 orl rat 2.48 g/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION: THR: MODERATE via oral route.
CARCINOGENICITY:
Review: IARC Cancer Review: Animal Inadequate Evidence
IARC: Not classifiable as a human carcinogen (Group 3) [610]
Status: NCI Carcinogenesis Bioassay (Dermal); No Evidence: Male and Female
Mouse [620]
MUTAGENICITY:
Mutagenic Data: mmo-sat 100 ug/plate
dnr-esc 1 mg/disc
cyt-hmn:fbr 200 ug/L
TERATOGENICITY:
Reproductive Effects Data:
TDLo orl-rat 6 gm/kg (6-15D preg)
TDLo orl-rat 7 gm/kg (6-15D preg)
TDLo orl-mus 13050 mg/kg (7-15D preg)
TDLo orl-mus 13050 mg/kg (7-15D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 1
Flammability (F): 1
Reactivity (R): 0
H1: Materials only slightly hazardous to health (see NFPA for details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 25 mg/24H SEV
eye-rbt 50 ug/24H SEV
Status: Reported in EPA TSCA Inventory, 1980
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
Intermediate for dyes and resins, rubber chemicals, fungicide, germicide,
preservative, food packaging. Disinfectant and fungicide for impregnation of
fruit wrappers and disinfection of seed boxes. Applied during dormant period
to control apple canker. Reagent for the determination of trioses.
Household disinfectant; dishwashing formulations.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This chemical is a skin and eye irritant. Corneal damage is possible upon
eye contact.
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS: Not available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and keep it away from oxidizing materials.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, you should
dampen the solid spill material with alcohol, then transfer the dampened
material to a suitable container. Use absorbent paper dampened with alcohol
to pick up any remaining material. Seal the absorbent paper, and any of your
clothes, which may be contaminated,in a vapor-tight plastic bag for eventual
disposal. Solvent wash all contaminated surfaces with alcohol followed by
washing with a strong soap and water solution. Do not reenter the contaminate
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
Check for contact lenses and remove them at once if present.
You should then immediately flush eyes with water from any source
for 15 minutes. Do not use oil or ointment in eyes. Arrange im-
mediate transportation to a medical facility.
INGESTION:
DO NOT INDUCE VOMITING. Phenols are very toxic poisons AND corrosive
and irritating, so that inducing vomiting may make medical problems worse.
IMMEDIATELY call a hospital or poison control center and locate activated
charcoal, egg whites, or milk in case the medical advisor recommends admini-
stering one of them.
If advice from a physician is not readily available and the victim is
conscious and not convulsing, give the victim a glass of activated charcoal
slurry in water or, if this is not available, a glass of milk, or beaten egg
whites and IMMEDIATELY transport victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
assure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include eye irritation with possible
corneal injury (necrosis); paleness, cyanosis, weakness, sweating, headache,
diarrhea, nausea, vomiting, diarrhea, dizziness, fainting, dark urine, central
nervous system depression, and deoxyribonuclease inhibition. Chronic exposure
may include irritation and lesions of the respiratory system.
FIREFIGHTING: Not available
SOURCES
SOURCES:
Clayton, G.D. and F.E. Clayton, Eds. Patty's Industrial Hygiene
and Toxicology. Vol. 2. Third Revised Edition. John Wiley
and Sons. New York. 1981. pp. 2616-7.
Weiss, G., Ed. Hazardous Chemicals Data Book. Noyes Data
Corporation. Park Ridge, NJ. 1980. p. 1070.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1982. p. 937; #P2,826-3.
Worthing, C.R., Ed. The Pesticide Manual, A World Compendium.
6th Ed. British Crop Protection Council. London, England.
1979. p. 419.
Gosselin, R.E., H.C. Hodge, R.P. Smith and M.N. Gleason. Clinical
Toxicology of Commercial Products. 4th Ed. Williams and
Wilkins, Co. Baltimore. 1976. p. 126; #453.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 805.
Sax, N.I. Dangerous Properties of Industrial Materials. 5th Ed.
Van Nostrand Reinhold. New York. 1979. p. 906.
Windholz, M., Ed. The Merck Index. 9th Ed. Merck and Co.
Rahway, NJ. 1976. p. 950; #7110.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. p. 676; #B-01275.
Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry
and Physics. 63rd Ed. CRC Press, Inc. Boca Raton, FL.
1982. p. C-437; #10998.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. DV5775000.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xxiii.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
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