NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000065
CAS NUMBER: 88-89-1
BASE CHEMICAL NAME: PICRICACID
PRIMARY NAME: PICRIC ACID
CHEMICAL FORMULA: C6H3N3O7
STRUCTURAL FORMULA:
WLN: WNR BQ CNW ENW
SYNONYMS:
LYDDITE
PERTITE
SHIMOSE
1,3,5-TRINITROPHENOL
PICRONITRIC ACID
PHENOL TRINITRATE
2,4,6-TRINITROPHENOL
2-HYDROXY-1,3,5-TRINITROBENZENE
CARBAZOTIC ACID
MELINITE
NITROXANTHIC ACID
C.I. 10305
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: LITERATURE: Pale yellow crystals
REPOSITORY: Yellow crystals
MOLECULAR WEIGHT: 229.12
SPECIFIC GRAVITY: 1.763
DENSITY: 1.763 g/mL
MP (DEG C): 121.8 - 123 C
BP (DEG C): >300 C (Sublimes/explodes)
SOLUBILITIES:
WATER : 1-10 mg/mL @ 24 C (RAD)
DMSO : >=100 mg/mL @ 23 C (RAD)
95% ETHANOL : 10-50 mg/mL @ 23 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 23 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Methanol: Soluble
Acetic acid: Soluble
Pyrimidene: Soluble
Chloroform: 1 gm/35 ml
ETHER : 1 gm/65 mL
BENZENE: 1 gm/10 mL
VOLATILITY:
Vapor pressure: < 1 mm Hg
Vapor density : 7.90
FLAMMABILITY(FLASH POINT):
This compound has a flash point of 150 C (302 F) and it can explode when
heated. Fires should be controlled from a safe distance. Use a dry chemical
or Halon extinguisher. Do not attempt to control large fires involving this
material, but, rather, keep surrounding areas cool with a water spray and
contact an explosive expert. The autoignition temperature is 299 C (572 F).
UEL: Not available LEL: Not available
REACTIVITY:
Reacts with metals, especially copper, lead and zinc, and with calcium,
ammonium, concrete and bases to form highly explosive and shock sensitive
picrate salts. Can also react vigorously with reducing agents. It is
also incompatible with all oxidizable substances, albumin, gelatin and
alkaloids.
STABILITY:
This compound can explode when rapidly heated or severely shocked. It may
also be sensitive to exposure to air. Solutions of this chemical should be
stable for 24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Impact sensitivity: 82 cm.
This compound is a more powerful explosive than TNT.
Refractive index: 1.763
pka 0.29 (25 C, H2O)
Odorless
Intensely bitter crystals
log P oct 2.03
TOXICITY
NIOSH REGISTRY NUMBER: TJ7875000
TOXICITY:
typ. dose mode specie amount unit other
LDLo scu dog 60 mg/kg
LDLo unk dog 60 mg/kg
LDLo orl cat 250 mg/kg
LDLo orl rbt 120 mg/kg
LDLo orl gpg 100 mg/kg
LDLo scu pgn 200 mg/kg
LDLo scu frg 200 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: MUTATION data. HIGH via oral, dermal and subcutaneous routes. An
irritant and an allergen. Dermal exposure may cause local and systemic
allergic reactions. Can cause allergic as well as irritative dermatitis.
CARCINOGENICITY: Not available
MUTAGENICITY:
Mutation Data:
mmo-esc 1800 ppm
mmo-sat 5 umol/plate
mma-sat 5 umol/plate
sln-dmg-orl 1250 umol/L
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 0.1 mg/m3 (skin) [610]
Final Limit: PEL-TWA 0.1 mg/m3 (skin) [610]
ACGIH: TLV-TWA 0.1 mg/m3 (skin); STEL 0.3 mg/m3, with a notice of intent to
delete STEL [610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Standards and Regulations: DOT-Hazard: Class A explosive; Label: Explosive A
Review: Toxicology Review
Status: "NIOSH Manual of Analytical Methods" Vol. 4
"NIOSH Manual of Analytical Methods" to be revised by June 1985
Reported in EPA TSCA Inventory, 1983
EPA Genetic Toxicology Program, January 1984
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Trinitrophenol, wetted
UN/ID NUMBER: UN1344
HAZARD CLASS: 4.1 SUBSIDIARY RISK: None PACKING GROUP: I
LABELS REQUIRED: Flammable solid
PACKAGING: PASSENGER: PKG. INSTR.: 416 MAXIMUM QUANTITY: 1 kg
CARGO : PKG. INSTR.: 412 MAXIMUM QUANTITY: 15 kg
SPECIAL PROVISIONS: A40
USES:
Explosives; matches; leather industry; electric batteries; etching copper;
manufacture of colored glass; textile mordant; reagent; antiseptic; astrin-
gent.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This chemical is absorbed through the skin and is an irritant. On decom-
position this compound emits highly toxic fumes and can explode. It is also
explosive if severely shocked.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS: Not available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under an inert atmosphere in a refrigerator
and away from all organic compounds. Protect this container from shock or
damage. STORE AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with ethanol to pick up any remaining material. Seal
the absorbent paper, and any of your clothes, which may be contaminated,in a
vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated
surfaces with ethanol followed by washing with a soap and water solution. Do
not reenter the contaminated area until the Safety Officer (or other responsi-
ble person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center.
Generally, the induction of vomiting is NOT recommended outside of a
physician's care due to the risk of aspirating the chemical into the victim's
lungs. However, if the victim is conscious and not convulsing and if medical
help is not readily available, consider the risk of inducing vomiting because
of the high toxicity of the chemical ingested. Ipecac syrup or salt water may
be used in such an emergency. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Exposure to this chemical may cause nausea, vomiting, diarrhea, epigastric
pain, oliguria, anuria, albuminuria, hematuria, yellow staining of tissues,
pruritis, skin eruptions, nasal irritation and epistaxis, bronchitis, vertigo,
casts, anemia, weakness, stupor, fever, convulsions, myalgia and death.
FIREFIGHTING: Not available
SOURCES
SOURCES:
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. TJ8750000.
Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry
and Physics. 63rd Ed. CRC Press, Inc. Boca Raton, FL.
1982. p. C-456, #11559.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 5, pp. 5607-8, #T-04234.
Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 1068, #7288.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 2230.
Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. pp. 1005-6.
Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. 1983. Listed.
Gosselin, R.E., H.C. Hodge, R.P. Smith and M.N. Gleason. Clinical
Toxicology of Commercial Products. 4th Ed. Williams and
Wilkins, Co. Baltimore. 1976. Setion II, pp. 196-7, #545.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1984. p. 894, #23,9801.
Deichmann, W.B. and H.W. Gerarde. Toxicology of Drugs and
Chemicals. Academic Press. New York. 1969. p. 476.
American Conference of Governmental Industrial Hygenists.
Threshold Limit Values for Chemical Substances and
Physical Agents in the Work Environment with Intended
Changes for 1982. American Conference of Governmental
Industrial Hygenists. Cincinnati, OH. 1982. p. 28.
American Conference of Governmental Industrial Hygenists.
Documentation of the Threshold Limit Values. 4th ed.
American Conference of Governmental Industrial Hygenists.
Cincinnati, OH. 1980. p. 342.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Steere, N.V., Ed. Handbook of Laboratory Safety. 2nd Ed.
CRC Press, Inc. Cleveland, OH. 1971. p. 804, #830.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Proctor, N.H. and J.P. Hughes. Chemical Hazards of the Workplace.
J.B. Lippincott. Philadelphia. 1978. p. 422.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 816.
International Technical Information Institute. Toxic and
Hazardous Industrial Chemicals Safety Manual for Handling
and Disposal with Toxicity and Hazard Data. International
Technical Information Institute. 1978. p. 423.
Sax, N.I. Dangerous Properties of Industrial Materials. 5th Ed.
Van Nostrand Reinhold. New York. 1979. p. 915
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xxiii.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
-------------------------------------------------------------