NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
DIMETHYL HYDROGENPHOSPHITE
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IDENTIFIERS
CATALOG ID NUMBER: 000609
CAS NUMBER: 868-85-9
BASE CHEMICAL NAME: DIMETHYLHYDROGENPHOSPHITE
PRIMARY NAME: DIMETHYL HYDROGENPHOSPHITE
CHEMICAL FORMULA: C2H7O3P
STRUCTURAL FORMULA: (CH3O)2P(O)H
WLN: 1OPHO&O1
SYNONYMS:
DIMETHYLHYDROGEN PHOSPHITE
DIMETHYL HYDROGEN PHOSPHITE
PHOSPHONIC ACID, DIMETHYL ESTER
DIMETHYLHYDROGENPHOSPHITE
DIMETHYL PHOSPHITE
DIMETHYL PHOSPHONATE
NCI-C54773
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear colorless liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 110.05
SPECIFIC GRAVITY: 1.200 @ 20/4 C [052,205,269,275]
DENSITY: Not available
MP (DEG C): Not available
BP (DEG C): 170-171 C [016,025,205,275]
SOLUBILITIES:
WATER : >=100 mg/mL @ 19.5 C (RAD)
DMSO : >=100 mg/mL @ 19.5 C (RAD)
95% ETHANOL : >=100 mg/mL @ 19.5 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 19.5 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Pyridine: >10% [047]
Ether: Miscible [052,205]
Common organic solvents: Miscible [052]
Pyrimidine: Soluble [016]
Alcohol: Miscible [052,205]
VOLATILITY:
Vapor pressure: 1 mm Hg @ 25 C; 8 mm Hg @ 50 C; 32 mm Hg @ 70 C [601]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 29 C (85 F) [269,275]. It is
flammable. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical can react with strong oxidizing agents, strong bases, acid
chlorides and water [269].
STABILITY:
This chemical is sensitive to moisture [269]. Gas chromatography
stability screening indicates that solutions of this chemical in 95% ethanol
are stable for at least 8 hours (RAD). NMR stability screening indicates
that solutions of this chemical in water are stable for less than four hours
(RAD). Solutions of this chemical in water hydrolyze upon storage [052].
OTHER PHYSICAL DATA:
Refractive index: 1.4030 @ 20 C [025,027,269]
Boiling point: 56.5 C @ 8 mm Hg [025,027]; 70 C @ 25 mm Hg [016,047]
Boiling point: 175.2 C @ 739 mm Hg [052]
Specific gravity: 1.1954 @ 25/22 C [052]; 1.191 @ 25/0 C [025,027]
Mild odor [052]
Fire point: 104 C (220 F) [052]
Tautomeric [027]
Vapor pressure: 64 mm Hg @ 95 C; 479 mm Hg @ 150 C [601]
Vapor pressure: 495 mm Hg @ 165 C; 560 mm Hg @ 170 C [601]
TOXICITY
NIOSH REGISTRY NUMBER: SZ7710000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 3050 mg/kg
LD50 skn rbt 2400 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Moderately toxic by ingestion and skin contact. An experimental
carcinogen. Mutagenic data.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 103 gm/kg/2Y-I
Status: NTP Carcinogenesis Studies (Gavage); Clear Evidence: Male Rat [620]
NTP Carcinogenesis Studies (Gavage); Equivocal Evidence: Female Rat
[620]
NTP Carcinogenesis Studies (Gavage); No Evidence: Male and Female
Mouse [620]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mma-sat 7500 ug/plate | cyt-ham:ovr 1600 mg/L
mma-mus:lym 1700 mg/L | sce-ham:ovr 250 mg/L
msc-mus:lym 2100 mg/L |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 500 mg/24H MLD
eye-rbt 20 mg/24H MOD
Status: EPA TSCA Chemical Inventory, 1986
EPA TSCA Section 8(e) Status Report 8EHQ-1080-0366
EPA TSCA Test Submission (TSCATS) Data Base, January 1989
Meets criteria for proposed OSHA Medical Records Rule
Relatively non-toxic [052]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Flammable liquids, n.o.s.
(Dimethyl hydrogenphosphite)
UN/ID NUMBER: UN1993
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 309, Y309 MAXIMUM QUANTITY: 60 L, 10 L
CARGO : PKG. INSTR.: 310 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
This compound is used as a flame retardant. It is a methylating
agent for n-heterocyclic compounds and s-methylate thioamides. It is
also a hydrophosphorylating reagent for alkenes and alkynes.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
The vapor or mist of this compound is irritating to the skin, eyes, mucous
membranes and upper respiratory tract [052,269]. When heated to decomposition
it emits toxic fumes of carbon monoxide, carbon dioxide, phosphorus oxides and
phosphine [269].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Neoprene Edmont 29-865 0.51 mm 120 min
PE/EVAL/PE Safety 4 4H 0.07 mm 240 min
Nitrile Edmont 37-155 0.46 mm 180 min
Butyl rubber North B-174 0.70 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this chemical in an explosion-proof refrigerator,
and protect it from moisture. If possible, it would be prudent to store this
compound under inert atmosphere. STORE AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Seal the absorbent
paper, as well as any of your clothing which may be contaminated, in a vapor-
tight plastic bag for eventual disposal. Wash any surfaces you may have
contaminated with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Exposure to this compound may cause irritation of the skin, eyes, mucous
membranes and upper respiratory tract [052,269].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. SZ7710000.
May 31, 1989.
[016] Weast, R.C., D.R. Lide, M.J. Astle, and W.H. Beyer, Eds. CRC Handbook
of Chemistry and Physics. 70th Ed. CRC Press, Inc. Boca Raton,
FL. 1989. p. C-429, #11431.
[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 2, p. 2209, #D-06913.
[027] Edmundson, R.S. Ed. Dictionary of Organophosphorus Compounds.
Chapman and Hall. New York. 1988. pp. 328-329, #D-00851.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. II, p. 1399, #DSG600.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. II, p. 110, #P01958.
[052] Midwest Research Institute. MRI Report for Dimethyl hydrogenphosphite.
Kansas City, MO. June 6, 1978; June 14, 1984; July 13, 1984.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[141] Veterinary Medicine Publishing Co. Veterinary Pharmaceuticals
and Biologicals. 6th Ed. Veterinary Medicine Publishing Co.
Lenexa, KS. 1988. pp. 643, 677.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-346, #d1046.
[240] Grayson, Martin, Ed. Kirk-Othmer Encyclopedia of Chemical Technology.
Volumes 1-24 and Supplement. 3rd Ed. John Wiley & Sons. New York.
1978-1984. Vol. 1, p. 286; Vol. 10, pp. 412, 428, 435.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 795, #A.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 620, #D17,845-4.
[601] Safety Consulting Engineers Inc. Vapor Pressure Test Results for
Dimethyl hydrogen phosphite. Report Number 8762-LR. Safety
Consulting Engineers Inc. Rosemont, IL. October 9, 1987.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 82.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
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