NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000758
CAS NUMBER: 81-07-2
BASE CHEMICAL NAME: SACCHARIN
PRIMARY NAME: SACCHARIN
CHEMICAL FORMULA: C7H5NO3S
STRUCTURAL FORMULA: Not printable
WLN: T56 BSWMVJ
SYNONYMS:
3-BENZISOTHIAZOLINONE 1,1-DIOXIDE
O-BENZOIC SULPHIMIDE
BENZOIC SULPHIMIDE
O-BENZOICSULPHIMIDE
BENZO-2-SULPHIMIDE
BENZOSULPHINIDE
O-BENZOYL SULPHIMIDE
3-HYDROXYBENZISOTHIAZOLE-S,S-DIOXIDE
1,2-BENZISOTHIAZOLIN-3-ONE, 1,1-DIOXIDE
ANHYDRO-O-SULFAMINEBENZOIC ACID
1,2-BENZISOTHIAZOL-3(2H)-ONE, 1,1-DIOXIDE
O-BENZOIC SULFIMIDE
O-BENZOSULFIMIDE
O-BENZOYL SULFIMIDE
NATREEN
SACARINA
SACCHARINA
SUCRE EDULCOR
SUCRETTE
2-SULPHOBENZOICIMIDE
SYNCAL
ZAHARINA
1,2-DIHYDRO-2-KETOBENZISOSULFONAZOLE
2,3-DIHYDRO-3-OXOBENZISOSULFONAZOLE
KANDISET
GARANTOSE
GLUCID
GLUSIDE
HERMESETAS
SACCHARIN ACID
550 SACCHARINE
SACCHARIN INSOLUBLE
SACCHARINE
SACCHARINOL
SACCHARINOSE
SACCHAROL
O-SULFOBENZIMIDE
O-SULFOBENZOIC ACID IMIDE
BENZOSULFIMIDE
BENZOIC SULFIMIDE
SAXIN
SYKOSE
2-SULFOBENZOIC ACID IMIDE
INSOLUBLE SACCHARIN
SACCHARIMIDE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White crystals
REPOSITORY: White crystalline solid
MOLECULAR WEIGHT: 183.19
SPECIFIC GRAVITY: Not available
DENSITY: 0.828 g/mL [016]
MP (DEG C): 229 C (decomposes) [016,047]
BP (DEG C): Sublimes [016,043,047]
SOLUBILITIES:
WATER : >=100 mg/mL @ 24 C (RAD)
DMSO : >=100 mg/mL @ 24 C (RAD)
95% ETHANOL : 1-5 mg/mL @ 24 C (RAD)
METHANOL : Not available
ACETONE : <1 mg/mL @ 24 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Boiling water: 1 g/25 mL [031,295,455]
Glycerol: 1 g/50 mL [031,295,395,455]
Solutions of alkali carbonates: Freely soluble [031,295,395,455]
Chloroform: Slightly soluble [031,062,205,295]
Alkali hydroxide solutions: Soluble [295,395,455]
Amyl acetate: Soluble [062]
Ethyl acetate: Soluble [062]
Ether: Slightly soluble [031,062,205,295]
Benzene: Soluble [062]
Alcohol: 1 g/31 mL [031]
Dilute ammonia solutions: Soluble [295,395,455]
VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong oxidizing agents [269].
STABILITY:
This chemical is stable under normal laboratory conditions. Solutions
of this chemical in water, DMSO, 95% ethanol or acetone should be stable for
24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Acid to litmus [031,295,395]
pH of 0.35% aqueous solution: 2.0 [031]
Odorless or faintly aromatic odor [295,455]
Sweet taste [031,062,455]
TOXICITY
NIOSH REGISTRY NUMBER: DE4200000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl mus 17 gm/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: An experimental carcinogen, neoplastigen, tumorigen and teratogen. A
possible human carcinogen. Mild acute toxicity by ingestion. Experi-
mental reproductive effects. Mutagenic data.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-mus 548 gm/kg/1Y-C
TDLo: skn-mus 9600 mg/kg/10W-I
TDLo: orl-rat 2008 gm/kg/2Y-C
TDLo: imp-mus 80 mg/kg
Review: IARC Cancer Review; Animal Sufficient Evidence
IARC Cancer Review; Human Inadequate Evidence
IARC possible human carcinogen (Group 2B) [015,395,610]
Status: NTP anticipated human carcinogen [610]
EPA Carcinogen Assessment Group [610]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mmo-sat 2 mg/plate | dnd-mus-ipr 100 mg/kg
mma-sat 2 mg/plate | bfa-mus/sat 2500 mg/kg
mmo-esc 4 gm/L | sln-dmg-orl 750 mg/kg
sce-hmn:lym 1000 ppm | sce-ham-orl 7500 mg/kg
cyt-smc 200 mg/L | sce-ham:ovr 1000 ppm
dnd-rat:lvr 3 mmol/L | sce-ham:lng 100 mg/L
dns-rat:lvr 100 pmol/L | cyt-mus-orl 168 gm/kg/24W-C
cyt-ham:fbr 30 mg/L |
TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-mus 16800 mg/kg (MGN)
TDLo: orl-mus 101 gm/kg (1-21D preg/21D post)
TDLo: orl-mus 252 gm/kg (MGN)
TDLo: orl-mus 155 mg/kg (7D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Review: Toxicology Review-8
Status: EPA Genetox Program 1988, Positive: Body fluid assay; Rodent dominant
lethal
EPA Genetox Program 1988, Positive: Host-mediated assay; S cerevisiae
gene conversion
EPA Genetox Program 1988, Positive: S cerevisiae-aneuploidy;
S cerevisiae-reversion
EPA Genetox Program 1988, Weakly positive: S cerevisiae-homozygosis
EPA Genetox Program 1988, Negative: SHE-clonal assay; Cell transform.-
C3H/1OT1/2
EPA Genetox Program 1988, Negative: N crassa-aneuploidy; E coli polA
without S9
EPA Genetox Program 1988, Negative: E coli polA with S9
EPA Genetox Program 1988, Inconclusive: D melanogaster-reciprocal
translocation
EPA Genetox Program 1988, Inconclusive: L5178Y cells in vitro-TK test
EPA TSCA Chemical Inventory, 1986
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This compound is used as a non-caloric sweetening agent and in formulation
of electroplating bath brighteners.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
When heated to decomposition this chemical emits very toxic fumes of NOx,
SOx, CO and CO2 [043,269]. This compound may cause skin, nose and throat
irritation [058].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Neoprene Pioneer N-44 0.63 mm 120 min
Butyl rubber North B-174 0.68 mm 240 min
PE/EVOH/PE Safety 4 4H 0.07 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this chemical under ambient temperatures,
and keep it away from oxidizing materials.
SPILLS AND LEAKAGE:
If you spill this chemical, you should dampen the solid spill material
with water, then transfer the dampened material to a suitable container. Use
absorbent paper dampened with water to pick up any remaining material. Seal
your contaminated clothing and the absorbent paper in a vapor-tight plastic
bag for eventual disposal. Wash all contaminated surfaces with a soap
and water solution. Do not reenter the contaminated area until the Safety
Officer (or other responsible person) has verified that the area has been
properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include anorexia, nausea, vomiting,
diarrhea and gastric hyperacidity [151]. Other symptoms include coughing,
chest pain and irritation of the eyes, nose and throat [058].
SOURCES
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