NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001086
CAS NUMBER: 80-15-9
BASE CHEMICAL NAME: CUMENEHYDROPEROXIDE
PRIMARY NAME: CUMENE HYDROPEROXIDE
CHEMICAL FORMULA: C9H12O2
STRUCTURAL FORMULA: C6H5C(CH3)2OOH
WLN: QOX1&1&R
SYNONYMS:
ALPHA,ALPHA-DIMETHYLBENZYL HYDROPEROXIDE
CUMENT HYDROPEROXIDE
CUMENYL HYDROPEROXIDE
CUMYL HYDROPEROXIDE
1-METHYL-1-PHENYLETHYL HYDROPEROXIDE
ALPHA-CUMYL HYDROPEROXIDE
ALPHA-CUMENE HYDROPEROXIDE
ISOPROPYLBENZENE HYDROPEROXIDE
RCRA WASTE NUMBER U096
UN 2116
PERCUMYL H
TRIGONOX K 80
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless to pale yellow liquid
REPOSITORY: Clear yellow liquid
MOLECULAR WEIGHT: 152.21
SPECIFIC GRAVITY: Not available
DENSITY: 1.024 g/mL @ 20 C (RAD)
MP (DEG C): <-40 C [051,058]
BP (DEG C): Decomposes @ 127 C [058]
SOLUBILITIES:
WATER : <0.1 mg/mL @ 18 C (RAD)
DMSO : Decomposes (RAD)
95% ETHANOL : >=100 mg/mL @ 18 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 18 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Soluble [062]
Esters: Soluble [062]
Hydrocarbons: Soluble [062]
Chlorinated hydrocarbons: Soluble [062]
VOLATILITY:
Vapor pressure: 13.9 mm Hg @ 20 C [058]
Vapor density : 5.0 [051,058]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 57 C (135 F) [058]. It is combustible.
Fires involving this material can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher. The autoignition temperature for this compound
is ~221 C (430 F) [051,058].
UEL: 6.5% [371] LEL: 0.9% [371]
REACTIVITY:
This chemical is a strong oxidizer [062]. It may ignite organic materials
[051,062]. It reacts with acids, acidic-type materials such as Friedel-Crafts
catalysts and oxidation catalysts; copper alloys, zinc-galvanized materials,
vermiculite, some plastics and certain resins [058]. It also reacts with oxi-
dizers, reducers (such as sulfur dioxide), lead, copper, chlorine, ferric
chloride, zinc chloride, metallic contaminants and strong alkalies. Vigorous
and exothermic decomposition occurs when brought into contact with mineral
acids [051,058]. It is incompatible with amines, organic bases and polymeriza-
tion accelerators. Spontaneous reaction, ignition and/or explosion may occur
if mixed with readily oxidizable or flammable materials [051]. It is also in-
compatible with metals such as aluminum, brass, zinc and cobalt [051,371].
STABILITY:
This chemical is heat-sensitive. It decomposes explosively. When the
temperature of mass reaches ~127 C the decomposition becomes autocatalytic
and vigorously exothermic [058]. It is also sensitive to light [058,371].
OTHER PHYSICAL DATA:
Density: 1.03 g/mL @ 25 C [371]
Sharp, aromatic odor [051,058,371]
Boiling point also reported as 153 C [042]
Boiling point: 100-101 C @ 8 mm Hg [275]
Vapor pressure (for 80-85% by weight): 0.6 mm Hg @ 20 C [051,058]
Freezing point: -9 C [371]
% Volatile by volume: 100% [058]
Liquid surface tension: 25 dynes/cm @ 20 C [371]
Liquid water interfacial tension: 30 dynes/cm @ 20 C [371]
pH: ~4 [058]
Evaporation rate (butyl acetate=1): ~0.1 [058]
Refractive index: 1.5210 @ 20 C [275]
Sinks in water [051,371]
Heat of combustion: -7400 cal/g [371]
Heat of decomposition: -475 cal/g [371]
TOXICITY
NIOSH REGISTRY NUMBER: MX2450000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 382 mg/kg
LC50 ihl rat 220 ppm/4H
LD50 ipr rat 95 mg/kg
LDLo orl mus 5000 mg/kg
LC50 ihl mus 200 ppm/4H
LD50 ipr mus 270 mg/kg
LD50 scu mus 490 mg/kg
LD50 skn rat 500 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: MUTATION data. HIGH via oral, inhalation, intraperitoneal and sub-
cutaneous routes. A powerful irritant to the skin and eyes of rabbits.
An experimental equivocal tumorigenic agent.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: scu-mus 8844 mg/kg/67W-I
TDLo: unr-mus 304 mg/kg
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mma-sat 100 ug/plate | mmo-sat 100 ug/plate
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 500 mg
skn-rbt 500 mg MLD
eye-rbt 1 mg
Standards and Regulations: DOT-Hazard: Organic peroxide; Label: Organic
peroxide
Status: EPA Genetox Program 1986, Negative: S cerevisiae gene conversion
EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, June 1987
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Organic peroxide type F, liquid
(Cumene hydroperoxide)
UN/ID NUMBER: UN3109
HAZARD CLASS: 5.2 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Organic peroxide
PACKAGING: PASSENGER: PKG. INSTR.: 500 MAXIMUM QUANTITY: 10 L
CARGO : PKG. INSTR.: 502 MAXIMUM QUANTITY: 25 L
SPECIAL PROVISIONS: A97
USES:
This compound is used in the production of acetone and phenol. It is a
polymerization catalyst, particularly in redox systems. It is a convenient
probe for studying the mechanism of NADPH dependent lipid peroxidation.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is corrosive to the eyes, skin and respiratory tract [051].
It is toxic by inhalation and skin absorption [058,062]. Contact of liquid
with the eyes or skin can be life threatening. The decomposition products of
this compound are eye, skin and respiratory irritants and may be skin sensi-
tizers [058]. Toxic vapors may form from the hot material [051,371].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-174 0.62 mm 240 min.
Neoprene Edmont 29-870 0.48 mm 120 min.
Viton North F-091 0.27 mm 240 min.
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
Splash proof safety goggles should be worn while handling this
chemical. Alternatively, a full face respirator, equipped as above,
may be used to provide simultaneous eye and respiratory protection.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated conditions
and away from all organic compounds. STORE AWAY FROM SOURCES OF
IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes
of the mouth, throat, and esophagus and, in addition, have a high risk of
being aspirated into the victim's lungs during vomiting which increases the
medical problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim
IMMEDIATELY to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include headache, throat
irritation, loss of sight, blistering and/or destruction of the skin, hair
loss, allergic skin reaction, respiratory irritation, nausea, dizziness,
weakness, loss of coordination, burns of the mouth and throat, severe abdominal
pain, blood vomiting and death. Prolonged exposure is defatting to the skin
and can produce dermatitis [058]. Other symptoms include redness and pain of
the skin and eyes, skin burns and blurred vision. Dermal exposure may cause
a throbbing sensation. Delayed erythema, edema and vesiculation may also
occur. Other symptoms may include sore throat, coughing, shortness of breath,
labored breathing and lung edema, vomiting and diarrhea, tremors, narcosis,
congested lungs and kidneys, salivation, respiratory difficulty, weight loss,
lung emphysema and thickening of the alveolar wall [051]. Irritation of the
mouth and stomach may also occur [371].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. MX2450000.
[042] Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 1656.
[051] Sax, N. Irving, Ed. Dangerous Properties of Industrial Materials
Report. Bi-monthly Updates. Van Nostrand Reinhold Company, Inc.
New York. November/December 1985. Vol. 5, #6, pp. 20-26.
[055] Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
p. 780.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. August/September 1988.
#3452-054, E-11; #5035-063, A-01.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 327.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 411, #24,750-2.
[371] U.S. Coast Guard, Department of Transportation. CHRIS
Hazardous Chemical Data. U.S. Coast Guard. Washington,
D.C. 1985. Vol. 1.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xxii.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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