NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 002231
CAS NUMBER: 79-27-6
BASE CHEMICAL NAME: TETRABROMOETHANE,1,1,2,2-
PRIMARY NAME: 1,1,2,2-TETRABROMOETHANE
CHEMICAL FORMULA: C2H2Br4
STRUCTURAL FORMULA: CHBr2CHBr2
WLN: EYEYEE
SYNONYMS:
ACETYLENE TETRABROMIDE
MUTHMANN'S LIQUID
TBE
TETRABROMOACETYLENE
1,1,2,2-TETRABROMOETHYLENE
UN 2504
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless to yellow, heavy liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 345.68
SPECIFIC GRAVITY: 2.9656 @ 20/4 C [017,025,047,275]
DENSITY: 2.964 g/mL [031]
MP (DEG C): -1 C [043,275,346,421]
BP (DEG C): 244 C [058]
SOLUBILITIES:
WATER : <1 mg/mL @ 20 C (RAD)
DMSO : >=100 mg/mL @ 20 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20 C (RAD)
METHANOL : Not available
ACETONE : <1 mg/mL @ 20 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Benzene: Soluble [017]
Ether: Miscible [031,421]
Glacial acetic acid: Miscible [031,421]
Alcohol: Miscible [031,421]
Chloroform: Miscible [031,421]
Aniline: Miscible [031,421]
Acid: Soluble > 10% [047]
Ethanol: Soluble >10% [047]
Acetic acid: Soluble [017]
VOLATILITY:
Vapor pressure: 0.1 mm Hg @ 20 C [055,058]; 1 mm Hg @ 65 C [038]
Vapor density : 11.9 [055,058,451]
FLAMMABILITY(FLASH POINT):
Literature sources indicate that this chemical is nonflammable [058,269,
275,451]. Fires involving this material can be controlled with a dry chemical,
carbon dioxide or Halon extinguisher. The autoignition temperature is 335 C
(635 F) [043,451].
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong bases and chemically active
metals [058,346]. It is also incompatible with hot iron, aluminum and zinc
in the presence of steam [346]. It may react with magnesium [269]. It
softens or destroys most plastics and rubber [058].
STABILITY:
This chemical is stable under normal laboratory conditions. Solutions
of this chemical in water, DMSO, 95% ethanol or acetone should be stable for
24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Boiling point: 114.8 C @ 10 mm Hg [017,025,047]
Boiling point: 119 C @ 15 mm Hg [058,269,275]
Boiling point: 151 C @ 54 mm Hg [025,031,043,062]
Starts to decompose @ 50 C [058]
Decomposes slowly @ 239-242 C [058]
Vapor pressure: 5 mm Hg @ 95.5 C; 10 mm Hg @ 110 C; 20 mm Hg @ 126 C [038]
Vapor pressure: 40 mm Hg @ 144 C; 60 mm Hg @ 155.1 C; 100 mm Hg @ 170 C [038]
Odor of camphor and iodoform [031,058]
Refractive index: 1.6353 @ 20 C [047,062,275]
TOXICITY
NIOSH REGISTRY NUMBER: KI8225000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 1200 mg/kg
LC50 ihl rat 549 mg/m3/4H
LD50 skn rat 5250 mg/kg
LD50 orl mus 269 mg/kg
LD50 ipr mus 443 mg/kg
LD50 orl rbt 400 mg/kg
LD50 orl gpg 400 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by inhalation and ingestion. An experimental neoplastigen.
Mutagenic data. It is an eye and skin irritant and a narcotic.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: skn-mus 130 gm/kg/74W-I
Status: NTP Carcinogenesis Studies; selected, February 1989
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
dnr-esc 29640 ug/disc | sce-ham:ovr 158 mg/L
mmo-sat 10 ug/plate | mma-sat 10 ug/plate
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 1 ppm [610]
Final Limit: PEL-TWA 1 ppm [610]
ACGIH: TLV-TWA 1 ppm [015,415,421,610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 3
Flammability (F): 0
Reactivity (R): 1
H3: Materials extremely hazardous to health but areas may be entered
with extreme care (see NFPA for details).
F0: Materials that will not burn (see NFPA for details).
R1: Materials which are normally stable but which may become unstable at
elevated temperatures and pressures or which may react with water with
some release of energy but not violently (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 500 mg/24H MOD
eye-rbt 100 mg MLD
Standards and Regulations: DOT-Hazard: ORM-A; Label: None
Status: EPA Genetox Program 1988, Positive: E coli polA without S9
EPA TSCA Chemical Inventory, 1986
EPA TSCA Section 8(e) Status Report 8EHQ-1078-0254
NIOSH Analytical Methods: see 1,1,2,2-Tetrabromoethane, 2003
Meets criteria for proposed OSHA Medical Records Rule
IDLH value: 10 ppm [346]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Tetrabromoethane
UN/ID NUMBER: UN2504
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 611, Y611 MAXIMUM QUANTITY: 60 L, 2 L
CARGO : PKG. INSTR.: 618 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
This compound is used in separating minerals by specific gravity or
density. It is also used as a solvent for fats, oils and waxes, as a solvent
in microscopy and as a fluid in liquid gauges.
COMMENTS:
This compound is a very potent mutagen [275].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may be fatal if swallowed [058]. It is harmful if inhaled
or absorbed through the skin [269]. It is an irritant of the skin and respira-
tory tract [058]. When heated to decomposition it emits highly toxic fumes of
carbon oxides, carbonyl bromide, bromine and hydrogen bromide gas [043,058,
269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
PVA Edmont 25-595 0.38 mm 240 min
Viton North F-091 0.25 mm 240 min
PE/EVOH/PE Safety 4 4H 0.07 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material under ambient temperatures.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include irritation of the eyes,
nose and upper respiratory tract, anorexia, jaundice, central nervous system
effects, urobilinuria, bilirubinuria and monocytosis [151]. Other symptoms
include nausea, severe headaches, irritation of the mucous membranes
and skin, and dizziness (prolonged exposure) [269]. It can cause abdominal
pains, lung irritation, dermatitis and kidney damage [058]. It can also cause
liver damage [421,451]. Skin contact may result in blisters [451].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. KI8225000.
June 6, 1989.
[017] Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 67th Ed. CRC Press, Inc. Boca Raton,
FL. 1986. p. C-265, #06665.
[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 5, p. 5131, #T-00271.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 1314, #9012.
[038] Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 518.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. II, p. 50, #ACK250.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 606, #E00324.
[055] Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
p. 155.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. June/July 1989.
#2654-017, A-05; #5846-103, D-03.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 13.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
C. Thomas, Publisher. Springfield, IL. 1986. p. 45.
[102] U.S. Department of Health and Human Services and U.S. Department
of Labor. NIOSH/OSHA Occupational Health Guidelines for Chemical
Hazards. 3 Vols. DHHS (NIOSH) Publication No. 81-123. January,
1981. Volume 3.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. p. II-164, #372.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 1641, #D.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 1381, #18,557-4 and #13,527-5.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. p. 179.
[326] Office of the Federal Register National Archives and Records
Administration. Code of Federal Regulations, Title 29, Labor,
Parts 1900 to 1910. U.S. Government Printing Office.
Washington. 1987. p. 677.
[346] Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
2nd Ed. Noyes, Publications. Park Ridge, NJ. 1985. p. 35.
[415] American Conference of Governmental Industrial Hygienists.
Threshold Limit Values and Biological Exposure Indices
for 1988-1989. American Conference of Governmental
Industrial Hygienists. Cincinnati, OH. 1988. p. 10.
[421] American Conference of Governmental Industrial Hygienists.
Documentation of the Threshold Limit Values. 5th Ed.
American Conference of Governmental Industrial Hygienists.
Cincinnati, OH. 1986. p. 9.
[451] National Fire Protection Association. Fire Protection Guide on
Hazardous Materials. 9th Ed. National Fire Protection
Association. Quincy, MA. 1986. pp. 325M-85, 49-86.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 22.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
-------------------------------------------------------------