NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001214
CAS NUMBER: 79-19-6
BASE CHEMICAL NAME: THIOSEMICARBAZIDE
PRIMARY NAME: THIOSEMICARBAZIDE
CHEMICAL FORMULA: CH5N3S
STRUCTURAL FORMULA:
WLN: ZMYZUS
SYNONYMS:
USAF EK-1275
N-AMINO THIOUREA
SEMICARBIZIDE,3-THIO
THIOCARBAMYLHYDRAZINE
SEMICARBAZIDE,THIO-
TSC
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: White, crystal powder
MOLECULAR WEIGHT: 91.14
SPECIFIC GRAVITY: Not available
DENSITY:Not available
MP (DEG C): 183 C degrees
BP (DEG C): Not available
SOLUBILITIES:
WATER : Not available
DMSO : Not available
95% ETHANOL : Not available
METHANOL : Not available
ACETONE : Not available
TOLUENE : Not available
OTHER SOLVENTS:
Water: Soluble.
Alcohol: Soluble.
VOLATILITY : Not available
FLAMMABILITY(FLASH POINT): Not available
UEL: Not available LEL: Not available
REACTIVITY: Not available
STABILITY: Not available
OTHER PHYSICAL DATA: Not available
TOXICITY
NIOSH REGISTRY NUMBER: VT4200000
TOXICITY:
typ. dose mode specie amount unit other
LD50 orl rat 9160 ug/kg
LD50 ipr mus 1 mg/kg
LD50 ivn mus 13 mg/kg
LD50 orl dog 10 mg/kg
LD50 orl cat 20 mg/kg
LD50 ipr gpg 24 mg/kg
LD50 orl bwd 9 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION: Not available
CARCINOGENICITY: Not available
MUTAGENICITY: dnd-hmn:hla 20umol/L
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Review: Toxicology Review
Status: Reported in EPA TSCA Inventory, 1980
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Poisonous solids, n.o.s.
(Thiosemicarbazide)
UN/ID NUMBER: UN2811
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Poison
PACKAGING: PASSENGER: PKG. INSTR.: 613, Y613 MAXIMUM QUANTITY: 25 kg, 1 kg
CARGO : PKG. INSTR.: 615 MAXIMUM QUANTITY: 100 kg
SPECIAL PROVISIONS: None
USES: As a reagent for detection of metals.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
Severe Poison
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Permeation data indicate that butyl rubber gloves may provide pro-
tection to contact with this compound. Butyl rubber over latex gloves
is recommended. However, if this chemical makes direct contact with
your gloves, or if a tear, hole or puncture develops, remove them at once.
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material in a refrigerator.
SPILLS AND LEAKAGE:
If you spill this chemical, use absorbent paper to pick up all liquid
spill material. Your contaminated clothing and absorbent paper should be
sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all
contaminated surfaces with alcohol followed by washing with a strong soap and
water solution. Do not reenter the contaminated area until the Safety Officer
(or other responsible person) has verified that the area has been properly
cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center.
Generally, the induction of vomiting is NOT recommended outside of a
physician's care due to the risk of aspirating the chemical into the victim's
lungs. However, if the victim is conscious and not convulsing and if medical
help is not readily available, consider the risk of inducing vomiting because
of the high toxicity of the chemical ingested. Ipecac syrup or salt water may
be used in such an emergency. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS: Not available
FIREFIGHTING:
A fire in your laboratory involving this chemical should be
extinguished with a dry chemical, carbon dioxide or halon extinguisher.
SOURCES
SOURCES:
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. not listed
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemicals. Aldrich Chemical Co., Inc. Milwaukee, WI.
1980. p.894,T3,340-345.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. listed
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. listed
Steere, N.V., Ed. Handbook of Laboratory Safety. 2nd Ed.
CRC Press, Inc. Cleveland, OH. 1971. not listed
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. listed
Proctor, N.H. and J.P. Hughes. Chemical Hazards of the Workplace.
J.B. Lippincott. Philadelphia. 1978. not listed
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p.1020
International Technical Information Institute. Toxic and
Hazardous Industrial Chemicals Safety Manual for Handling
and Disposal with Toxicity and Hazard Data. International
Technical Information Institute. 1978. not listed
Sax, N.I. Dangerous Properties of Industrial Materials. 5th Ed.
Van Nostrand Reinhold. New York. 1979. not listed
Windholz, M., Ed. The Merck Index. 9th Ed. Merck and Co.
Rahway, NJ. 1976. p.1209 REF#9100
Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry
and Physics. 60th Ed. CRC Press, Inc. Boca Raton, FL.
1982. p. C-496,550
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic
Effects of Chemical Substances. DHEW (NIOSH) Publication
No. 79-100. National Institute for Occupational Safety
and Health. Cincinnati, OH. 1979. VT4200000
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xxii.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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