NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001573
CAS NUMBER: 7732-18-5
BASE CHEMICAL NAME: WATER
PRIMARY NAME: WATER
CHEMICAL FORMULA: H2O
STRUCTURAL FORMULA: H2O
WLN: QH
SYNONYMS:
DIHYDROGEN OXIDE
WATER, DISTILLED
ICE
STEAM
SNOW
HYDROGEN OXIDE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear colorless liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 18.02
SPECIFIC GRAVITY: 0.997 @ 25/4 C [031]
DENSITY: 0.995 g/mL @ 32 C [205]
MP (DEG C): Not available
BP (DEG C): 90 C @ 525.97 mm Hg [205]
SOLUBILITIES:
WATER : >=100 mg/mL @ 19 C (RAD)
DMSO : >=100 mg/mL @ 19 C (RAD)
95% ETHANOL : >=100 mg/mL @ 19 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 19 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS: Not available
VOLATILITY:
Vapor pressure: 23.756 mm Hg @ 25.0 C [205]
Vapor density : >1 [058]
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
nonflammable. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. A water spray may also be
used [058].
UEL: Not available LEL: Not available
REACTIVITY: Not available
STABILITY:
This chemical is stable under normal laboratory conditions [058].
Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be
stable for 24 hours under normal laboratory conditions (RAD).
OTHER PHYSICAL DATA:
Density: 0.958 g/mL @ 100 C [205]
Boiling point: 80 C @ 355.40 mm Hg; 95 C @ 634.06 mm Hg [205]
Odorless [043,058,062,295]
Tasteless [043,295]
Weak electrolyte [062]
Dipole moment: 1.76 @ 25 C (in benzene) [031]; 1.86 @ 25 C (in dioxane) [031]
Surface tension: 75.83 dynes/cm @ 0 C; 72.88 dynes/cm @ 20 C [205]
Refractive index: 1.33395 @ 0 C; 1.33300 @ 20 C; 1.33194 @ 30 C [205]
Triple point: 273.16 K @ 4.6 mm Hg [062]
Critical temperature: 374.2 C [031]
Critical pressure: 218 atmospheres [031]
Dielectric constant: 87.74 @ 0 C [031,205]; 80.10 @ 20 C [205]; 76.55 @ 30 C
[205]
Latent heat of condensation: 540 cal/g [043]
Bulk density: 8.337 lbs/gal (62.3 lb/cu ft) [043]
Surface tension: 73 dynes/cm @ 20 C [043]
Evaporation rate (n-butyl acetate=1): 0.4 [043]
Viscosity: 0.01002 poise @ 20 C [043,062]
Latent heat of fusion: 80 cal/g [043]
TOXICITY
NIOSH REGISTRY NUMBER: ZC0110000
TOXICITY:
typ. dose mode specie amount units other
LD50 ipr mus 190 gm/kg
LD50 ivn mus 25 gm/kg
LDLo ivn rbt 13 gm/kg
LDLo orl cat 320 gm/kg
LDLo orl dog 629 gm/kg
LDLo orl gpg 429 gm/kg
TDLo orl inf 333 gm/kg
TDLo orl man 42.86 gm/kg
LDLo orl rbt 368 gm/kg
LDLo rec rbt 450 gm/kg
LDLo rec wmn 180 gm/kg/28H
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Human systemic effects by ingestion of very large amounts. Human and
experimental death reported by various routes at sufficiently large
doses.
CARCINOGENICITY: Not available
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
Not available |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Status: EPA Genetox Program 1988, Inconclusive: B subtilis rec assay
EPA TSCA Chemical Inventory, 1986
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This compound is used as a solvent, suspending agent, industrial coolant,
diluent, moderator in nuclear reactors, nutrient substance and power source.
It is also used in beer and carbonated beverages, hydration of lime, paper
coatings, textile processing, debarking logs, filtration, washing and scouring,
sulfur mining, hydrolysis, Portland cement, hydraulic systems, steam generation
and in the food industry.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
Information concerning acute hazards of this chemical is not available.
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
Permeation Test Results For The Neat (Undiluted) Chemical:
The permeation test results for the neat (undiluted) chemical are given
below. The breakthrough times of this chemical are given for each glove type
tested. The table is a presentation of actual test results, not specific
recommendations or suggestions. Avoid glove types which exhibit breakthrough
times of less than the anticipated task time plus an adequate safety factor.
If this chemical makes direct contact with your glove, or if a tear, puncture
or hole develops, replace them at once.
Glove Type Model Number Thickness Breakthrough Time
Butyl rubber North B-161 0.71 mm 480 min
Neoprene Edmont 29-870 0.48 mm 480 min
Viton North F-091 0.25 mm 480 min
Unknown North Silvershield 0.10 mm 480 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material at ambient temperatures.
SPILLS AND LEAKAGE:
If you should spill this chemical, use absorbent paper to pick up
all liquid spill material. Seal the absorbent paper, as well as any
of your clothing which may be contaminated, in a vapor-tight plastic
bag for eventual disposal. Wash any surfaces you may have contaminated
with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified
that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
If symptoms (such as redness or irritation) develop, immediately transport
the victim to a hospital.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound via eye contact include edema of the
corneal stroma and epithelium (which increases sensitivity to glare) [099].
Other symptoms of exposure include headache and vomiting which may be followed
by confusion, disorientation and restlessness progressing to convulsions and
coma. It may also cause stupor [295]. It has reportedly caused tremors and
muscle contraction or spasticity. In infants it may cause convulsions, effect
on seizure threshold, hypermotility, diarrhea and increased body temperature
[015]. It may also cause fever [043].
Symptoms of exposure in animals include hemolysis with or without anemia,
convulsions and effect on seizure threshold [015].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. ZC0110000.
February 14, 1989.
[017] Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 67th Ed. CRC Press, Inc. Boca Raton,
FL. 1986. p. B-94, #h63.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 1441, #9853.
[038] Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 545.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. III, p. 3487, #WAT259.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. February/March 1989.
#2606-586, A-13; #8362-001, F-13.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 1232.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
C. Thomas, Publisher. Springfield, IL. 1986. pp. 982-983.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. pp. 10-26, 10-54,
10-91, 10-99.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 1540, #19,529-4.
[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
The Pharmaceutical Press. London. 1982. pp. 1669-1670.
[455] The Pharmaceutical Society of Great Britain. The Pharmaceutical Codex.
11th Edition. The Pharmaceutical Press. London. 1979. pp. 991-992.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Not listed.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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