NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000766
CAS NUMBER: 77-09-8
BASE CHEMICAL NAME: PHENOLPHTHALEIN
PRIMARY NAME: PHENOLPHTHALEIN
CHEMICAL FORMULA: C20H14O4
STRUCTURAL FORMULA: Not printable
WLN: T56 BVO DHJ DR DQ& DR DQ
SYNONYMS:
3,3-BIS(P-HYDROXYPHENYL)PHTHALIDE
3,3-BIS(4-HYDROXYPHENYL)-1(3H)-ISOBENZOFURANONE
NCI-C55798
FEEN-A-MINT GUM
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White or yellowish-white crystalline powder
REPOSITORY: Fine, pale orange powder
MOLECULAR WEIGHT: 318.33
SPECIFIC GRAVITY: 1.299 @ 25/4 C [205]
DENSITY: 1.299 g/mL [031,043]
MP (DEG C): 258-262 C [031,043,205]
BP (DEG C): Not available
SOLUBILITIES:
WATER : <1 mg/mL @ 19 C (RAD)
DMSO : >=100 mg/mL @ 19 C (RAD)
95% ETHANOL : 10-50 mg/mL @ 19 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 19 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Very slightly soluble [031,205]
Alkalies: Soluble [058,062,159]
Pyridine: Soluble [047]
Ether: 10 mg/mL [031,205,295]
Benzene: Insoluble [053,900]
Alcohol: 1 g/12 mL [031]
Acid: Soluble [047]
Pyrimidine: Soluble [017]
Dilute solutions of alkali hydroxides: Soluble [295,455]
Hot solutions of alkali carbonates: Soluble [295]
VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Literature sources indicate that this compound is nonflammable [058].
Fires involving this material can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher. A water spray may also be used [058].
UEL: Not available LEL: Not available
REACTIVITY:
This compound is incompatible with alkaloids [031,058].
STABILITY:
Solutions of this chemical in water, DMSO, 95% ethanol or acetone should
be stable for 24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Specific gravity: 1.277 @ 32/4 C [017,047]
pH of aqueous solution: acidic [058]
Colorless to pH 8.5; pink to deep-red above pH 9 [031]
Colorless in presence of large amounts of alkali [062]
Dissociation constant: pKa 9.7 @ 25 C [455]
Odorless [053,295,455]
Tasteless [295,455]
Absorbs insignificant amounts of moisture @ 25 degrees @ relative humidities
up to about 90% [295,455]
Lambda max: 522 nm, 374 nm [275]
Forms a red solution in hot solutions of alkali carbonates [295]
Forms a red solution in dilute solutions of alkali hydroxides [455]
TOXICITY
NIOSH REGISTRY NUMBER: SM8380000
TOXICITY:
typ. dose mode specie amount units other
LDLo ipr rat 500 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Moderately toxic by intraperitoneal route.
CARCINOGENICITY:
Status: NTP Carcinogenesis Studies; on test (prechronic studies), January 1988
MUTATION DATA:
test lowest dose | test lowest dose
---------- ---------------- | ---------- ----------------
Not available |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Review: Toxicology Review
Status: EPA Genetox Program 1988, Negative: B subtilis rec assay
EPA Genetox Program 1988, Inconclusive: B subtilis rec assay
EPA TSCA Chemical Inventory, 1986
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This compound is used as a cathartic, laxative in veterinary medicine,
acid-base indicator and laboratory reagent.
COMMENTS:
This compound is excreted chiefly in the feces, but some may be excreted
by the kidneys imparting a red color to alkaline urine. A 1% alcoholic
solution is used as an indicator in titrations of mineral and organic acids and
most alkalies. It is not suitable for ammonia. It is very sensitive to CO2.
In estimating carbonates, the liquid must be boiled. Borax can be titrated
with phenolphthalein as an indicator only when glycerol is present, because the
color gradually fades away as the acid is added.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may cause skin, eye and gastrointestinal tract irritation
[058]. When heated to decomposition it emits acrid smoke and fumes [043].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Natural rubber Ackwell 5-109 0.15 mm 480 min
Neoprene Edmont 29-870 0.41 mm 480 min
Nitrile Edmont 37-155 0.39 mm 480 min
PVC Edmont 34-100 0.18 mm 480 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material at ambient temperatures.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Exposure to this compound may cause purging, collapse and erythematous,
itching skin rash that may progress to persistent ulceration [058,301]. Acute
exposure may cause hypotension, vomiting, watery or bloody diarrhea, pallor,
rapid heart rate, coma and death. Other symptoms include burning pain in the
mouth and stomach and tenesmus [058]. Eye contact may result in edema of the
eyelids and conjunctival ecchymoses [058,099]. It may also result in irrita-
tion, redness and pain [058]. It has occasionally caused albuminuria and
hemoglobinurea [295,455]. It may also cause skin rash [159,164,455]. Other
symptoms include pink coloring of the urine and feces, allergic reactions
including fixed-drug eruption, Stevens-Johnson syndrome (resembles lupus
erythematosus), osteomalacia, protein-losing gastroenteropathy, and fluid and
electrolyte deficits [406]. Exposure has also caused cerebral and pulmonary
edema, oliguria and severe acidosis [151,295]. Hypothermia has also been
reported [151]. Other symptoms include abdominal cramps, cardiac and resp-
iratory distress, lack of sphincter control, flaccid paralysis, fixed mydria-
sis, intense cyanosis, undetectable blood pressure or pulse, toxic epidermal
necrolysis, and bullous lesions on the hands, lips, mouth and tongue [295].
SOURCES
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