NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001357
CAS NUMBER: 75-36-5
BASE CHEMICAL NAME: ACETYLCHLORIDE
PRIMARY NAME: ACETYL CHLORIDE
CHEMICAL FORMULA: C2H3ClO
STRUCTURAL FORMULA:
WLN: Not available
SYNONYMS:
ACETIC ACID, CHLORIDE
ACETIC CHLORIDE
ETHANOYL CHLORIDE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: LITERATURE: Colorless liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 78.50
SPECIFIC GRAVITY: 1.1051 @ 20/4 C
DENSITY: 1.104 g/mL
MP (DEG C): -112 C
BP (DEG C): 50.9 C
SOLUBILITIES:
WATER : Reaction
DMSO : Reaction
95% ETHANOL : Reaction
METHANOL : Not available
ACETONE : >=100 mg/mL @ 21 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Soluble
Glacial acetic acid: Soluble
Petroleum Ether: Soluble
ETHER : Soluble
BENZENE: Soluble
VOLATILITY:
Vapor pressure: 135 mm Hg @ 7.5 C
Vapor density : 2.7; 2.1 @ 38 C
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 4 C (40 F). It is flammable. Fires
involving this compound can be controlled with a dry chemical, carbon dioxide
or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This compound reacts violently with water, alcohol and DMSO. It also reacts
with oxidizing agents and strong bases.
STABILITY:
This compound is sensitive to moisture and may fume on contact. Gas
chromatography stability screening indicates that solutions of the chemical
in acetone are stable for up to two hours (RAD).
OTHER PHYSICAL DATA:
Refractive Index: 1.3886 @ 20 C
Pungent odor
Ignition temperature: 390 C
TOXICITY
NIOSH REGISTRY NUMBER: AO6390000
TOXICITY:
typ. dose mode specie amount units other
TCLo ihl hmn 2 ppm/1M
AQTX/TLM96: 100-10 ppm
SAX TOXICITY EVALUATION:
THR: A human irritant. HIGH irritant via oral and inhalation routes.
CARCINOGENICITY: Not available
MUTATION DATA: Not available
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 3
Flammability (F): 3
Reactivity (R): 2
H3: Materials extremely hazardous to health but areas may be entered
with extreme care (see NFPA for details).
F3: Materials which can be ignited under almost all normal temperature
conditions (see NFPA for details).
R2: Materials which are normally unstable and readily undergo violent
chemical change but do not detonate (see NFPA for details).
NFPA possible hazard in use of water
OTHER TOXICITY DATA:
Standards and Regulations: DOT-Hazard: Flammable liquid; Label: Flammable
liquid
DOT-IMO: Flammable liquid; Label: Flammable liquid,
corrosive
Status: Reported in EPA TSCA Inventory, 1983
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Acetyl chloride
UN/ID NUMBER: UN1717
HAZARD CLASS: 3 SUBSIDIARY RISK: 8 PACKING GROUP: II
LABELS REQUIRED: Flammable liquid and Corrosive
PACKAGING: PASSENGER: PKG. INSTR.: 306, Y306 MAXIMUM QUANTITY: 1 L, 1 L
CARGO : PKG. INSTR.: 308 MAXIMUM QUANTITY: 5 L
SPECIAL PROVISIONS: None
USES:
Acetylating agent; in testing for cholesterol; determination
of water in organic liquids; dye stuffs; pharmaceuticals.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is corrosive to the tissues and it is a lachrymator. It is
highly toxic through inhalation and ingestion. When heated to decomposition
it emits toxic fumes.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemicals:
Recommendations based on permeation test results, are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): Butyl rubber (to 70 minutes)
RECOMMENDED RESPIRATOR:
When working with this chemical, wear a NIOSH-approved full face
chemical cartride respirator equipped with the appropriate organic vapor
cartridges. If that is not available, a half face respirator similarly
equipped plus airtight goggles can be substituted. However, please note
that half face respirators provide a substantially lower level of protection
than do full face respirators.
OTHER: Not available
STORAGE PRECAUTIONS:
You should keep this material in a tightly closed container under
an inert atmosphere, and store it in an explosion-proof freezer. STORE
AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you should spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION,
then use absorbent paper to pick up all liquid spill material. Your contamina-
ted clothing and absorbent paper should be sealed in a vapor-tight plastic bag
for eventual disposal. Solvent wash all contaminated surfaces with acetone
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes
of the mouth, throat, and esophagus and volatile chemicals have a high risk of
being aspirated into the victim's lungs during vomiting. Thus, the risk of
increasing the medical problems by inducing vomiting of a volatile corrosive
chemical is very high.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
This comound is extremely destructive to the mucous membranes, upper
respiratory tract, eyes and skin. Inhalation may be fatal as a result of
spasm, inflammation and edema of the larynx and bronchi; chemical pneumonitis
and pulmonary edema. Other symptoms include a burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, vomiting and
lachrymation.
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