NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000336
CAS NUMBER: 72-54-8
BASE CHEMICAL NAME: RHOTHANE
PRIMARY NAME: RHOTHANE
CHEMICAL FORMULA: C14H10Cl4
STRUCTURAL FORMULA: (ClC6H4)2CHCHCl2
WLN: GYGYR DG&R DG
SYNONYMS:
1,1-DICHLORO-2,2-BIS(P-CHLOROPHENYL)ETHANE
1,1-BIS(P-CHLOROPHENYL)-2,2-DICHLOROETHANE
DICHLORODIPHENYL DICHLOROETHANE
1,1-BIS(4-CHLOROPHENYL)-2,2-DICHLOROETHANE
2,2-BIS(P-CHLOROPHENYL-1,1-DICHLOROETHANE
2,2-BIS(4-CHLOROPHENYL)-1,1-DICHLOROETHANE
1,1-DICHLORO-2,2-BIS(PARACHLOROPHENYL)ETHANE
1,1-DICHLORO-2,2-DI(4-CHLOROPHENYL)ETHANE
P,P'-DICHLORODIPHENYLDICHLOROETHANE
TETRACHLORODIPHENYLETHANE
TDE
DDD
P,P'-DDD
DILENE
ROTHANE
RHOTHANE D-3
P,P'-TDE
NCI-C00475
ENT 4,225
ME-1700
NA 2761
OMS 1078
RCRA WASTE NUMBER U060
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless crystals
REPOSITORY: Tan powder
MOLECULAR WEIGHT: 320.05
SPECIFIC GRAVITY: 1.385 [051]
DENSITY: 1.385 g/mL [173]
MP (DEG C): 109-110 C [031,047,173,346]
BP (DEG C): 193 C [051]
SOLUBILITIES:
WATER : <1 mg/mL @ 18.5 C (RAD)
DMSO : >=100 mg/mL @ 18.5 C (RAD)
95% ETHANOL : 5-10 mg/mL @ 18.5 C (RAD)
METHANOL : Not available
ACETONE : 10-50 mg/mL @ 18.5 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS: Not available
VOLATILITY:
Vapor pressure: 0.000001 mm Hg @ 30 C [051]
Vapor density : 11 [043,051,055]
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong oxidizing agents [269].
STABILITY:
This chemical is stable under normal laboratory conditions. Solutions
of this chemical in water, DMSO, 95% ethanol or acetone should be stable for
24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA: Not available
TOXICITY
NIOSH REGISTRY NUMBER: KI0700000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 113 mg/kg
LDLo orl mus 600 mg/kg
LD50 skn rbt 1200 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion. Moderately toxic by skin contact. An experimental
carcinogen, neoplastigen and tumorigen. Mutagenic data.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 54 gm/kg/78W-C
TDLo: orl-mus 39 gm/kg/2Y-C
Status: NCI Carcinogenesis Bioassay (Feed): Equivocal: Male Rat [620]
NCI Carcinogenesis Bioassay (Feed): Negative: Female Rat, Male and
Female Mouse [620]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
cyt-rat:oth 10 ug/L | otr-mus:emb 28400 nmol/L
hma-mus/srm 1500 mg/kg |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Standards and Regulations: DOT-Hazard: ORM-A; Label: None
Status: Meets criteria for proposed OSHA Medical Records Rule
EPA Genetox Program 1988, Positive: In vitro cytogenetics-nonhuman;
Host-mediated assay
EPA Genetox Program 1988, Inconclusive: E coli polA without S9
EPA Genetox Program 1988, Inconclusive: D melanogaster Sex-linked
lethal
EPA TSCA Test Submission (TSCATS) Data Base, January 1989
Estimated fatal oral dose (humans): 5000 mg/kg [031,051]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Organochlorine pesticides, solid, toxic, n.o.s.
UN/ID NUMBER: UN2761
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 619, Y619 MAXIMUM QUANTITY: 100 kg, 10 kg
CARGO : PKG. INSTR.: 619 MAXIMUM QUANTITY: 200 kg
SPECIAL PROVISIONS: None
USES:
This compound is used as a non-degradable pesticide and a nonsystemic
contact and systemic insecticide.
COMMENTS:
This compound is a component of technical grade DDT [031].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by skin absorption [025]. It may cause slight
irritation of the skin [031]. When heated to decomposition this compound
emits toxic fumes of chlorides, carbon monoxide, carbon dioxide and hydrogen
chloride gas [043,269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Nitrile Edmont 37-155 0.38 mm 480 min
PVA Edmont 25-545 0.40 mm 480 min
Viton North F-121 0.31 mm 240 min
Teflon Clean Room Products 0.05 mm 480 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this chemical at ambient temperatures, and protect
it from oxidizing materials.
SPILLS AND LEAKAGE:
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION,
then you should dampen the solid spill material with acetone and transfer the
dampened material to a suitable container. Use absorbent paper dampened with
acetone to pick up any remaining material. Seal your contaminated clothing
and the absorbent paper in a vapor-tight plastic bag for eventual disposal.
Solvent wash all contaminated surfaces with acetone followed by washing with
a soap and water solution. Do not reenter the contaminated area until the
Safety Officer (or other responsible person) has verified that the area has
been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include anorexia, nausea,
vomiting, diarrhea, dermatitis, apathy from mild dulling of interest to
profound psychotic depression, gynecomastia, hematuria, leukopenia, thrombo-
cytopenia and lassitude [173]. It may cause slight irritation of the skin
and lethargy. Chronic exposure may cause atrophy of the adrenal cortex and
liver damage [031].
SOURCES
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of Chemical Substances. On-line Ed. National Institute for
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[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 2, p. 1720, #D-02504.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 444, #3044.
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[055] Verschueren, K. Handbook of Environmental Data on Organic
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[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
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[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
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[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
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NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
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