NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001795
CAS NUMBER: 67-68-5
BASE CHEMICAL NAME: DIMETHYLSULFOXIDE
PRIMARY NAME: DIMETHYL SULFOXIDE
CHEMICAL FORMULA: C2H6OS
STRUCTURAL FORMULA: (CH3)2SO
WLN: OS1&1
SYNONYMS:
DMSO
METHYL SULFOXIDE
DIMETHYL SULPHOXIDE
SULFINYLBIS(METHANE)
METHANE, SULFINYLBIS-
METHYLSULFINYLMETHANE
A 10846
DELTAN
DEMESO
DEMASORB
DEMAVET
DEMSODROX
DERMASORB
DIMEXIDE
DIPIRARTRIL-TROPICO
DMS-70
DMS-90
DOLICUR
DOLIGUR
DOMOSO
DROMISOL
DURASORB
GAMASOL 90
HYADUR
INFILTRINA
M 176
NSC-763
RIMSO-50
SOMIPRONT
SQ 9453
SYNTEXAN
TOPSYM
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear colorless liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 78.13
SPECIFIC GRAVITY: 1.1014 @ 20/4 C [016,047]
DENSITY: 1.100 g/mL @ 20 C [029,031,043,205]
MP (DEG C): 18.5 C [029,043,055,062]
BP (DEG C): 189 C [016,029,031,036]
SOLUBILITIES:
WATER : >=100 mg/mL @ 20 C (RAD)
DMSO : >=100 mg/mL @ 20 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 20 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Soluble [016,047,062,205]
Most organic solvents (except straight chain hydrocarbons): Soluble [058]
Chloroform: Soluble [062,205]
Ether: Soluble [016,047,205]
Benzene: Soluble [062,205]
VOLATILITY:
Vapor pressure: 0.42 mm Hg @ 20 C [055]
Vapor density : 2.71 [055]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 95 C (203 F) [031,062,269,275]. It
is combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. A water spray may also be
used [058,269]. The autoignition temperature is 215 C (419 F) [043].
UEL: 63% [058] LEL: 2.6% [043,900]
REACTIVITY:
This compound is incompatible with many acyl, aryl and non-metal halides,
methyl bromide, NIO4, oxalyl chloride, phosphorous trioxide, phosphorous
trichloride, phosphoryl chloride, silver fluoride, silver difluoride, sodium
hydride, sulfur dichloride, disulfur dichloride, sulfuryl chloride,
tetrachlorosilane, thionyl chloride, boron compounds, 4(4'-bromobenzoyl)-
acetanilide, carbonyl diisothiocyanate, dinitrogen tetroxide, hexachlorocyclo-
triphosphazine, copper trichloroacetic acid, metal alkoxides, trifluroacetic
acid anhydride, magnesium perchlorate, metal oxosalts, perchloric acid,
periodic acid, sulfur trioxide and metal salts of oxoacids [043]. It reacts
violently or explosively with acetyl chloride, benzenesulphonyl chloride,
cyanuric chloride, phosphorous oxychloride, silicon tetrachloride, SCl2, sulfur
chloride, nitrous oxide, iodine pentafluoride, magnesium perchlorate, HIO4 or
sodium hydrate. Violent reactions or ignition occurs with potassium powder,
potassium t-butoxide, sodium isopropoxide or trifluoroacetic anhydride. This
compound is incompatible with bromomethane, metal nitrates and perchlorates
[036]. It is incompatible with alkali metals and oxidizing materials [058].
It is also incompatible with acid chlorides, phosphorus halides, strong acids,
strong reducing agents and diborane [269].
STABILITY:
This compound is hygroscopic [031,043]. Solutions of this chemical in
water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal
lab conditions (RAD).
OTHER PHYSICAL DATA:
Refractive index: 1.4795 @ 20 C; 1.4787 @ 21 C [031]
Mild ripe olive or vegetable oil odor [058]
Bitter taste with sweet aftertaste [031,051]
Viscosity: 1.1 centipoise @ 27 C [031]
log P octanol: -2.03 [055]
100% volatile by volume [058]
Dielectric constant: 48.9 @ 20 C [062]
Specific heat: 0.7 cal/g [031,062]
Evaporation rate (ether=1): >1 [900]
Boiling point: 85-87 C @ 20 mm Hg [016,047]; 83 C @ 17 mm Hg, 56.6 C @
5.11 mm Hg, 47.4 C @ 2.82 mm Hg, 30 C @ 0.79 mm Hg [031]
UEL also reported as 28.5% [043,900]
TOXICITY
NIOSH REGISTRY NUMBER: PV6210000
TOXICITY:
typ. dose mode specie amount units other
TDLo ivn man 606 mg/kg
LD50 orl rat 14500 mg/kg
LD50 ipr rat 8200 mg/kg
LD50 scu rat 12 gm/kg
LD50 ivn rat 5360 mg/kg
LD50 orl mus 7920 mg/kg
LD50 ipr mus 2500 mg/kg
LD50 scu mus 14 gm/kg
LD50 ivn mus 3100 mg/kg
LD50 ivn dog 2500 mg/kg
LD50 orl ckn 12 gm/kg
LD50 orl bwd 100 mg/kg
LD50 unr rat 1300 mg/kg
LDLo ivn cat 200 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion. Moderately toxic by intravenous and intraperitoneal
routes. Mildly toxic by subcutaneous route. An experimental tumorigen
and teratogen. Human systemic effects by intravenous route. Experi-
mental reproductive effects. Human mutagenic data.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 59 gm/kg/81W-I
TDLo: scu-rat 220 gm/kg/82W-I
TDLo: orl-mus 65340 mg/kg/66W-I
TDLo: scu-mus 66 gm/kg/66W-I
MUTATION DATA: See RTECS printout for data
TERATOGENICITY: See RTECS printout for data
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 1
Flammability (F): 1
Reactivity (R): 0
H1: Materials only slightly hazardous to health (see NFPA for details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 10 mg/24H open MLD
skn-rbt 500 mg/24H MLD
eye-rbt 100 mg
eye-rbt 500 mg/24H MLD
Review: Toxicology Review-3
Status: EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, September 1989
EPA Genetox Program 1988, Positive: Aspergillus-aneuploidy;
S cerevisiae gene conversion
EPA Genetox Program 1988, Negative: SHE-clonal assay; Cell
transform.-mouse embryo
EPA Genetox Program 1988, Negative: D melanogaster-whole sex
chromosome loss; Host-mediated assay
EPA Genetox Program 1988, Negative: Cell transform.-RLV F344 rat
embryo
EPA Genetox Program 1988, Negative: N crassa-aneuploidy; E coli polA
with S9
EPA Genetox Program 1988, Negative: Histidine reversion-Ames test;
In vitro SCE-nonhuman
EPA Genetox Program 1988, Negative: D melanogaster Sex-linked lethal
EPA Genetox Program 1988, Inconclusive: Aspergillus-recombination;
Carcinogenicity-mouse/rat
EPA Genetox Program 1988, Inconclusive: D melanogaster-reciprocal
translocation
EPA Genetox Program 1988, Inconclusive: Rodent dominant lethal;
B subtilis rec assay
EPA Genetox Program 1988, Inconclusive: E coli polA without S9
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
This compound is used in antifreeze, hydraulic fluid, paint and varnish
removers and potentially as a pharmaceutical solvent. It is also used as a
clearing solution for examination of microscopic fungus, as a solvent, as a
treatment for interstitial cystitis, as an analytical reagent, in the
manufacture of synthetic fibers, industrial cleaners and pesticides, in the
preservation of cells at low temperatures and in the diffusion of drugs into
the bloodstream by topical applications. In medicine this compound is used as
an anti-inflammatory agent. It is also used in veterinary medicine. It is
used in plant pathology and nutrition, as a metal-complexing agent and as an
analgesic.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is a skin and eye irritant [043,269]. It freely penetrates
the skin and may carry dissolved chemicals with it into the body [043]. It may
be harmful by inhalation, ingestion or skin absorption [269]. When heated to
decomposition this compound may emit poisonous gases and toxic fumes of sulfur
oxides, sulfur dioxides, formaldehyde, methyl mercaptan, carbon monoxide and
carbon dioxide [043,058,269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
Permeation Test Results For The Neat (Undiluted) Chemical:
The permeation test results for the neat (undiluted) chemical are given
below. The breakthrough times of this chemical are given for each glove type
tested. The table is a presentation of actual test results, not specific
recommendations or suggestions. Avoid glove types which exhibit breakthrough
times of less than the anticipated task time plus an adequate safety factor.
If this chemical makes direct contact with your glove, or if a tear, puncture
or hole develops, replace them at once.
Glove Type Model Number Thickness Breakthrough Time
Butyl rubber North B-174 0.86 mm 480 min
Neoprene Edmont 29-870 0.46 mm 240 min
Unknown North Silvershield 0.10 mm 480 min
Latex Ackwell 5-109 0.15 mm 30 min
Viton North F-091 0.36 mm 75 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material at ambient temperatures and protect it
from moisture. If possible, it would be prudent to store this compound under
inert atmosphere.
SPILLS AND LEAKAGE:
If you should spill this chemical, use absorbent paper to pick up
all liquid spill material. Seal the absorbent paper, as well as any
of your clothing which may be contaminated, in a vapor-tight plastic
bag for eventual disposal. Wash any surfaces you may have contaminated
with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified
that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include rapid breathing,
restlessness, disturbances of color vision, photophobia, headache, diarrhea,
dermatitis, wheal and flare formation, anesthesia, renal and hepatic damage,
gastric distress, drowsiness, vertigo, dyspnea, tenderness in the lumbar and
abdomen and death [151]. Other symptoms may include nausea, vomiting,
jaundice, anaphylactic reaction and corneal opacity [043]. A garlic-like taste
in the mouth and transient chemical cystitis may also occur [158]. Exposure to
this compound may lead to irritation, redness, itching and scaling of the skin,
chills and cramps [036,051]. It may also cause urticaria, allergic reactions
and lethargy [051]. This compound may cause narcotic effects, convulsions,
visual disturbances and hemolysis [301]. Vasodilation, maceration, chest pains
and hypersensitivity may also occur [295]. Other symptoms may include
irritation and reddening of the eyes, smarting of the skin, sedation and
dizziness [058]. Allergic skin irritation may also occur [900].
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