NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001094
CAS NUMBER: 67-64-1
BASE CHEMICAL NAME: ACETONE
PRIMARY NAME: ACETONE
CHEMICAL FORMULA: C3H6O
STRUCTURAL FORMULA: CH3COCH3
WLN: 1V1
SYNONYMS:
DIMETHYLFORMALDEHYDE
DIMETHYLKETAL
DIMETHYL KETONE
KETONE, DIMETHYL
KETONE PROPANE
BETA-KETOPROPANE
METHYL KETONE
PROPANONE
2-PROPANONE
PYROACETIC ACID
PYROACETIC ETHER
RCRA WASTE NUMBER U002
CHEVRON ACETONE
UN 1090
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear colorless liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 58.08
SPECIFIC GRAVITY: 0.791 @ 20/4 C [055,275,371,430]
DENSITY: 0.786 gm/cc @ 22.7 C (RAD)
MP (DEG C): -94 C [025,031,275,421]
BP (DEG C): 56 C [036,275,295,451]
SOLUBILITIES:
WATER : >=100 mg/mL @ 22 C (RAD)
DMSO : >=100 mg/mL @ 22 C (RAD)
95% ETHANOL : >=100 mg/mL @ 22 C (RAD)
METHANOL : Miscible [455]
ACETONE : >=100 mg/mL @ 22 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Miscible [017,031,205,295]
Dimethylformamide: Miscible [031]
Most oils: Miscible [031,062,295]
Ether: Miscible [031,043,205,295]
Benzene: Soluble [017,047]
Organic solvents: Miscible [025]
VOLATILITY:
Vapor pressure: 180 mm Hg @ 20 C [421,430]; 270 mm Hg @ 30 C [055]
Vapor density : 2.0 [043,058,371,451]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of -18 C (0 F) [031,043,058,371]. It
is flammable. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. The autoignition temperature
of this compound is 465 C (869 F) [043,371,451].
UEL: 12.8% [043,058,062,421] LEL: 2.6% [043,058,062]
REACTIVITY:
This chemical is incompatible with acids, oxidizers, potassium tert-
butoxide, alkalies, amines, alkanolamines, ammonia, aldehydes and chlorinated
compounds [058]. It is also incompatible with chromium oxide, (nitric acid +
acetic acid), permonosulfuric acid, NaOBr, (sulfuric acid + potassium dichro-
mate), (thiodiglycol + hydrogen peroxide), trichloromelamine, chloroform and
sulfuric acid [043]. It may react with reducing agents [269]. It reacts
explosively with active carbon, (nitric acid + sulfuric acid), bromine tri-
fluoride, bromine, nitrosyl chloride, nitrosyl perchlorate, nitryl perchlorate,
chromyl chloride, chromium trioxide, (dioxygen difluoride + carbon dioxide),
nitric acid, hydrogen peroxide and peroxomonosulfuric acid [036,043]. It may
also react explosively with (nitrosyl chloride + platinum), thiotrithiazyl per-
chlorate and (2,4,6-trichloro-1,3,5-triazine + water) [043]. It reacts vio-
lently with bromoform, (chloroform + base) and sulfur dichloride [036,043].
It reacts to form explosive products with 2-methyl-1,3-butadiene [043].
STABILITY:
This chemical is sensitive to moisture [269]. It is also sensitive to
light [052,295]. It may be sensitive to heat [058]. Solutions of this
chemical in water, DMSO, 95% ethanol or acetone should be stable for 24
hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Refractive index: 1.3585 @ 20 C [269,275]
Sweet, fruity odor [055]
Pungent, sweetish taste [031,295]
Specific gravity: 0.788 @ 25/25 C [031]; 0.792 @ 20/20 C [062]
Specific gravity: 0.786 @ 23.5/21 C [052]
Odor threshold: 100 ppm [371]
Evaporation rate (butyl acetate=1): <1 [058]
Boiling point: 56.0 C @ 751 mm Hg [052]
Vapor pressure: 1 mm Hg @ -59.4 C; 100 mm Hg @ 7.7 C; 760 mm Hg @ 56.5 C [038]
Vapor pressure: 89 mm Hg @ 5 C; 400 mm Hg @ 39.5 [055]
log P octanol: -0.24 [055]
TOXICITY
NIOSH REGISTRY NUMBER: AL3150000
TOXICITY:
typ. dose mode specie amount units other
TCLo ihl man 440 ug/m3/6M
TCLo ihl man 10 mg/m3/6H
TCLo ihl hmn 500 ppm
TCLo ihl man 12000 ppm/4H
LDLo unr man 1159 mg/kg
LDLo ipr rat 500 mg/kg
LD50 orl mus 3000 mg/kg
LCLo ihl mus 110 gm/m3/1H
LD50 ipr mus 1297 mg/kg
LDLo orl dog 8 gm/kg
LD50 orl rat 5800 mg/kg
LC50 ihl rat 50100 mg/m3/8H
LDLo ipr dog 8 gm/kg
LDLo scu dog 5 gm/kg
LD50 skn rbt 20 gm/kg
LDLo scu gpg 5000 mg/kg
TDLo orl man 2857 mg/kg
LD50 ivn rat 5500 mg/kg
LDLo ivn rbt 1576 mg/kg
LD50 orl rbt 5340 mg/kg
LDLo ivn mus 4 gm/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Moderately toxic by various routes. A skin and severe eye irritant.
Human systemic effects by inhalation and ingestion. Narcotic in high
concentrations. In industry, no injurious effects have been reported
other than skin irritation resulting from its defatting action, or
headache from prolonged inhalation. A common air contaminant. Dan-
gerous disaster hazard due to fire and explosion hazard.
CARCINOGENICITY: Not available
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
cyt-ham:fbr 40 gm/L | sln-smc 47600 ppm
TERATOGENICITY:
Reproductive Effects Data:
TCLo: ihl-mam 31500 ug/m3/24H (1-13D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 1000 ppm [015,327,545,610]
Final Limit: PEL-TWA 750 ppm; STEL 1000 ppm [015,327,545,610]
OSHA STEL does not apply to the acetate fiber industry; it is in
effect for all other sectors [610]
ACGIH: TLV-TWA 750 ppm; STEL 1000 ppm [015,415,421,610]
NIOSH Criteria Document: Recommended exposure limit to this class of
compounds-air: TWA 590 mg/m3 [015]
NFPA Hazard Rating: Health (H): 1
Flammability (F): 3
Reactivity (R): 0
H1: Materials only slightly hazardous to health (see NFPA for details).
F3: Materials which can be ignited under almost all normal temperature
conditions (see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-hmn 500 ppm
skn-rbt 395 mg open MLD
eye-rbt 3950 ug SEV
eye-rbt 20 mg/24H MOD
skn-rbt 500 mg/24H MLD
Standards and Regulations: DOT-Hazard: Flammable liquid; Label: Flammable
liquid
Status: NIOSH Analytical Methods: see Ketones I, 1300
EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, June 1988
EPA Genetox Program 1988, Negative: SHE-clonal assay; Cell transform.-
mouse embryo
EPA Genetox Program 1988, Negative: Cell transform.-RLV F344 rat
embryo
EPA Genetox Program 1988, Negative: In vitro cytogenetics-nonhuman
EPA Genetox Program 1988, Negative: Histidine reversion-Ames test; In
vitro SCE-nonhuman
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Acetone
UN/ID NUMBER: UN1090
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 305, Y305 MAXIMUM QUANTITY: 5 L, 1 L
CARGO : PKG. INSTR.: 307 MAXIMUM QUANTITY: 60 L
SPECIAL PROVISIONS: None
USES:
This compound is used in the manufacture of smokeless powder, paints,
varnishes, lacquers, organic chemicals, pharmaceuticals, sealants, adhesives,
methyl isobutyl ketone, mesityl oxide, acetic acid (ketene process), diacetone
alcohol, chloroform, iodoform, bromoform, explosives, airplane dopes, rayon,
photographic films, isoprene, methyl isobutyl carbinol, methyl methacrylate
and bisphenol A. It is used as as solvent for cellulose acetate, nitrocellu-
lose, acetylene, fats, oils, waxes, resins, rubber, plastics, rubber cements,
pharmaceuticals, potassium iodide and permanganate. It is also used in storing
acetylene gas, in purifying paraffin, in hardening and dehydrating tissues and
to clean and dry parts of precision equipment. It is used in extraction of
various principles from animal and plant substances, as a delusterant for
cellulose acetate fibers, in specification testing of vulcanized rubber pro-
ducts, as a cosmetic ingredient, as a dye intermediate and in paint and varnish
removers.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by ingestion and inhalation [025,058,062]. It is
an irritant of the eyes, mucous membranes, nose, throat and upper respiratory
tract [269,346,371,430]. It rapidly penetrates skin [430]. It is absorbed
through the lungs [295,455]. It is narcotic in high concentrations [043,058,
062,371]. When heated to decomposition it emits toxic fumes of carbon monoxide,
carbon dioxide and unidentified organic compounds in black smoke [058,269].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Permeation Test Results For The Neat (Undiluted) Chemical:
The permeation test results for the neat (undiluted) chemical are given
below. The breakthrough times of this chemical are given for each glove type
tested. The table is a presentation of actual test results, not specific
recommendations or suggestions. Avoid glove types which exhibit breakthrough
times of less than the anticipated task time plus an adequate safety factor.
If this chemical makes direct contact with your glove, or if a tear, puncture
or hole develops, replace them at once.
Glove Type Model Number Thickness Breakthrough Time
Viton North F-091 0.23 mm 0 min
Butyl rubber North B-174 0.76 mm 480 min
PVA Edmont 25-545 0.25 mm 4 min
Neoprene Edmont 29-870 0.74 mm 30 min
Nitrile Edmont 37-155 0.38 mm 5 min
Latex Ackwell 5-109 0.15 mm 0 min
RECOMMENDED RESPIRATOR:
When working with this chemical, wear a NIOSH-approved full face
chemical cartride respirator equipped with the appropriate organic vapor
cartridges. If that is not available, a half face respirator similarly
equipped plus airtight goggles can be substituted. However, please note
that half face respirators provide a substantially lower level of protection
than do full face respirators.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical in an explosion-proof refrigerator
and keep it away from oxidizing materials and acids. Protect from moisture
and light. STORE AWAY FROM SOURCES OF IGNITION. If possible, it would be
prudent to store this chemical under inert atmosphere.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Seal the absorbent
paper, as well as any of your clothing which may be contaminated, in a vapor-
tight plastic bag for eventual disposal. Wash any surfaces you may have
contaminated with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being
aspirated into the victim's lungs during vomiting which increases the medical
problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include headache, nausea,
vomiting and dizziness [058,421,430]. High concentrations cause narcosis
[031,036,043,295]. Irritation of the eyes, nose and throat may occur [346,
401,430]. Irritation of the mucous membranes and upper respiratory tract
may also occur [269,371]. On prolonged contact, irritation of the skin may
occur [043,058]. Other symptoms include central nervous system effects,
convulsions, kidney and liver injury, unconsciousness and death [058]. Coma
has been reported [036]. Fatigue, excitement and bronchial irritation have
also been reported [031]. Exposure may cause restlessness, hematemesis,
collapse and stupor [151]. It may also cause slight intoxication, central
nervous system depression, lassitude, drowsiness, loss of appetite, insomnia,
somnolence, loss of strength, shallow respiration, hyperglycemia, weakness of
the limbs, lightheadedness, general malaise and hepatorenal lesions [430]. It
can cause dryness of the mouth, incoordinated movements, loss of coordinated
speech, rapid and irregular respiration rate, fainting, coughing, inflammation
of the stomach and duodenum and giddiness [421]. It can also cause changes in
EEG, changes in carbohydrate metabolism, nasal and respiratory system effects,
muscle weakness and metabolic changes [043]. Hypoglycemia may result [301].
Skin contact may result in drying of the skin [031,058]. It may also
result in mild edema and hyperemia. Prolonged skin contact may lead to
defatting of the skin resulting in dermatitis [430]. Erythema also occurs
from prolonged contact [031]. Ingestion may cause gastric irritation [036].
Eye contact may result in burns [058]. Severe eye damage may occur [036].
Stinging sensation of the eyes may also occur [099].
Use of alcoholic beverages enhances the toxic effects of this compound.
Preexisting eye or skin disorders may be aggravated by exposure [058].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. AL3150000.
March 20, 1989.
[017] Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 67th Ed. CRC Press, Inc. Boca Raton,
FL. 1986. p. C-51, #306.
[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 1, p. 17, #A-00118.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 10, #58.
[036] Bretherick, L., Ed. Hazards in the Chemical Laboratory. 4th Ed.
The Royal Society of Chemistry. London. 1986. p. 155.
[038] Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 520.
[039] Boublik, T., V. Fried and E. Hala. The Vapor Pressures of Pure
Substances. pp. 120-121.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. II, pp. 25-26, #ABC750.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 25, #A00398.
[051] Sax, N. Irving, Ed. Dangerous Properties of Industrial Materials
Report. Bi-monthly Updates. Van Nostrand Reinhold Company, Inc.
New York. March/April 1981; Vol. 1, No. 4, pp. 25-26. May/June
1984; Vol. 4, No. 3, pp. 9-23.
[052] Midwest Research Institute. MRI Report for Acetone.
Kansas City, MO. April 9, 1986.
[055] Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
pp. 147-150.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. April/May 1989.
#9106-167, A-11.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
pp. 8-9.
[066] Bretherick, L. Handbook of Reactive Chemical Hazards. 3rd Ed.
Butterworths. London. 1985. pp. 365-366.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
C. Thomas, Publisher. Springfield, IL. 1986. pp. 41-42.
[105] The Society of Dyers and Colourists. Colour Index. Vols. 1-7.
The Society of Dyers and Colourists. Yorkshire, England.
American Association of Textile Chemists and Colorists.
Research Triangle Park, NC. 1971-1982. Vol. 4, p. 4696.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. p. II-183, #466.
[195] Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds. CFTA Cosmetic
Ingredient Dictionary. 3rd Ed. The Cosmetic, Toiletry and
Fragrance Assn. Inc. Washington. 1982. p. 2.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-84, #a34.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 12, #B.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 10, #27,072-5.
[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
The Pharmaceutical Press. London. 1982. p. 1450.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. p. 198.
[327] Office of the Federal Register National Archives and Records
Administration. Code of Federal Regulations, Title 29, Labor,
Parts 1900 to 1910. U.S. Government Printing Office.
Washington. 1988. p. 706.
[346] Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
2nd Ed. Noyes, Publications. Park Ridge, NJ. 1985. pp. 28-29.
[371] U.S. Coast Guard, Department of Transportation. CHRIS
Hazardous Chemical Data. U.S. Coast Guard. Washington,
D.C. 1985. Volume 1.
[401] Nutt, A. R. Toxic Hazards of Rubber Chemicals. Elsevier
Applied Science Publishers. New York. 1984. pp. 27,
123, 164.
[415] American Conference of Governmental Industrial Hygienists.
Threshold Limit Values and Biological Exposure Indices
for 1988-1989. American Conference of Governmental
Industrial Hygienists. Cincinnati, OH. 1988. p. 10.
[421] American Conference of Governmental Industrial Hygienists.
Documentation of the Threshold Limit Values. 5th Ed.
American Conference of Governmental Industrial Hygienists.
Cincinnati, OH. 1986. pp. 6-7.
[430] Clayton, G.D. and F.E. Clayton, Eds. Patty's Industrial Hygiene
and Toxicology. Vol. 2. Third Revised Edition. John Wiley
and Sons. New York. 1981. Vol. IIC, pp. 4720-4728.
[451] National Fire Protection Association. Fire Protection Guide on
Hazardous Materials. 9th Ed. National Fire Protection
Association. Quincy, MA. 1986. p. 325M-10.
[455] The Pharmaceutical Society of Great Britain. The Pharmaceutical Codex.
11th Edition. The Pharmaceutical Press. London. 1979. p. 6.
[545] Office of the Federal Register National Archives and Records
Administration. Federal Register, Dept. of Labor, Part III.
U.S. Government Printing Office. Washington. January 19, 1989.
p. 2923.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xviii.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. October 3, 1990.
Listed.
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