NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
2,5-TOLUENEDIAMINE SULFATE
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IDENTIFIERS
CATALOG ID NUMBER: 000342
CAS NUMBER: 6369-59-1
BASE CHEMICAL NAME: TOLUENEDIAMINESULFATE,2,5-
PRIMARY NAME: 2,5-TOLUENEDIAMINE SULFATE
CHEMICAL FORMULA: C7H10N2.H2SO4
STRUCTURAL FORMULA: CH3C6H3(NH2)2.H2SO4
WLN: ZR DZ F1 &H2 S-O4
SYNONYMS:
2,5-DIAMINOTOLUENE SULPHATE
2-METHYL-1,4-BENZENEDIAMINE SULFATE
TOLUENE-2,5-DIAMINE SULPHATE
P-TOLUENEDIAMINE SULPHATE
2-METHYL-P-PHENYLENEDIAMINE SULPHATE
1,4-BENZENEDIAMINE, 2-METHYL-, SULFATE
C.I.76043
C.I. OXIDATION BASE 4
FOURAMINE STD
2,4-TOLUENEDIAMINE SULFATE
TOLUYLENE-2,5-DIAMINE SULPHATE
P-TOLUYLENEDIAMINE SULPHATE
P-TOLYLENEDIAMINE SULPHATE
NCI-C01832
P-TOLUENEDIAMINE SULFATE
2,5-TOLUENDIAMINE SULFATE
2,5-TDS
OXIDATION BASE 14
2-METHYL-PARA-PHENYLENEDIAMINE SULPHATE
PARA-TOLUENEDIAMINE SULPHATE
P-TOLUENEDIAMINE SULPHATE
TOLUYLENE 2,5-DIAMINE SULPHATE
PARA-TOLYLENEDIAMINE SULPHATE
PARA-TOLYLENEDIAMINE SULPHATE
PARA, META-TOLYLENEDIAMINE SULPHATE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: LITERATURE: Light tan powder
REPOSITORY: Light purple powder
MOLECULAR WEIGHT: 202.25
SPECIFIC GRAVITY: Not available
DENSITY: Not available
MP (DEG C): Not available
BP (DEG C): Not available
SOLUBILITIES:
WATER : <1 mg/mL @ 20 C (RAD)
DMSO : <1 mg/mL @ 20 C (RAD)
95% ETHANOL : <1 mg/mL @ 20 C (RAD)
METHANOL : Not available
ACETONE : <1 mg/mL @ 20 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS: Not available
VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available. It is probably combusti-
ble. Fires involving this material should be controlled using a dry chemical,
carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY: Not available
STABILITY:
This chemical is stable under normal laboratory conditions. Solutions of
this chemical in water, DMSO, 95% ethanol or acetone should be stable for
24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA: Not available
TOXICITY
NIOSH REGISTRY NUMBER: XT0524000
TOXICITY:
typ. dose mode specie amount unit other
Not available
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: An experimental equivocal tumorigenic agent, +/- carcinogen. HIGH via
oral or intraperitoneal routes.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-mus 66 gm/kg/78W-C
Status: NCI Carcinogenesis Bioassay (Feed); Negative: Male and Female Rat,
Male and Female Mouse [620]
MUTATION DATA:
test lowest dose | test lowest dose
---------- ---------------- | ---------- -----------------
Not available |
TERATOGENICITY:
Reproductive Effects Data:
TDLo: scu-mus 480 mg/kg (6-15D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Status: Reported in EPA TSCA Inventory, 1983
EPA Genetic Toxicology Program, January 1984
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
Intermediate in dye production; dye.
COMMENTS:
Reviewed by: RLT/860707
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may cause irritation on contact. When heated to decomposition
it emits very toxic fumes. It is an experimental carcinogen.
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemical:
Recommendations based on permeation test results are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): No information available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material in a refrigerator.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then
dampen the solid spill material with toluene, then transfer the dampened
material to a suitable container. Use absorbent paper dampened with toluene
to pick up any remaining material. Your contaminated clothing and absorbent
paper should be sealed in a vapor-tight plastic bag for eventual disposal.
Solvent-wash all contaminated surfaces with toluene followed by washing with
a soap and water solution. Do not reenter the contaminated area until
the Safety Officer (or other responsible person) has verified that the area
has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include skin irritation.
SOURCES
SOURCES:
Midwest Research Institute. MRI Report for 2,5-Toluenediamine sulfate.
Kansas City, MO. August 9, 1978.
Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds. CFTA Cosmetic
Ingredient Dictionary. 3rd Ed. The Cosmetic, Toiletry and
Fragrance Assn. Inc. Washington. 1982. p. 320.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1986. p. 416; #15,433-4.
The Society of Dyers and Colourists. Colour Index. Vols. 1-7.
The Society of Dyers and Colourists. Yorkshire, England.
American Association of Textile Chemists and Colorists.
Research Triangle Park, NC. 1971-1982. Vol. 3, p. 3260.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. XT0524000.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 891.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
International Agency for Research on Cancer, World Health
Organization. IARC Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man. International
Agency for Research on Cancer. Geneva. 1971-1982.
Vol. 16, pp. 98-109.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 107.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
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