NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 002028
CAS NUMBER: 623-42-7
BASE CHEMICAL NAME: METHYLBUTYRATE
PRIMARY NAME: METHYL BUTYRATE
CHEMICAL FORMULA: C5H10O2
STRUCTURAL FORMULA: CH3(CH2)2CO2CH3
WLN: Not available
SYNONYMS:
N-BUTYRIC ACID, METHYL ESTER
BUTANOIC ACID METHYL ESTER
METHYL N-BUTANOATE
METHYL-N-BUTYRATE
BUTYRIC ACID, METHYL ESTER
ETHYL ACETIC ACID
PROPYLFORMIC ACID
UN1237
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless liquid
REPOSITORY: Clear, colorless liquid
MOLECULAR WEIGHT: 102.15
SPECIFIC GRAVITY: 0.898 @ 20 C
DENSITY: 0.898 g/mL
MP (DEG C): -95 C
BP (DEG C): 102 C
SOLUBILITIES:
WATER : 10-50 mg/mL @ 22 C (RAD)
DMSO : >=100 mg/mL @ 22 C (RAD)
95% ETHANOL : >=100 mg/mL @ 22 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 22 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS: Not available
ETHER : Miscible
VOLATILITY:
Vapor pressure: 0.84 mm Hg @ 20 C; 40 mm Hg @ 29.6 C; 60 mm Hg @ 37.4 C
Vapor density : 3.53
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 14 C (57 F). It is flammable.
Fires involving this material can be controlled with a dry chemical,
carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This compound reacts with strong oxidizers and strong bases.
STABILITY:
This chemical is stable under normal laboratory conditions. Solutions of this
chemical should be stable for 24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Refractive Index: 1.3875 @ 20 C
Penetrating and obnoxious odor
TOXICITY
NIOSH REGISTRY NUMBER: ET5500000
TOXICITY:
typ. dose mode specie amount units other
LC50 ihl mus 18 gm/m3/2H
LD50 orl rbt 3380 mg/kg
LD50 skn rbt 3560 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR = Moderate via oral and skin routes.
CARCINOGENICITY: Not available
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
Not available |
TERATOGENICITY (Reproductive Effects Data): Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 2
Flammability (F): 3
Reactivity (R): 0
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F3: Materials which can be ignited under almost all normal temperature
conditions (see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 500 mg/24H MOD
Standards and Regulations: DOT-Hazard: Flammable liquid; Label: Flammable
liquid
Status: Reported in EPA TSCA Inventory, 1983
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Methyl butyrate
UN/ID NUMBER: UN1237
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 305, Y305 MAXIMUM QUANTITY: 5 L, 1 L
CARGO : PKG. INSTR.: 307 MAXIMUM QUANTITY: 60 L
SPECIAL PROVISIONS: None
USES:
Solvent for ethyl cellulose; solvent mixture for nitrocellulose; flavoring.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is a strong irritant to the eyes, skin, mucous membranes and
upper respiratory tract. When heated to decomposition it emits toxic fumes.
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemical:
Recommendations based on permeation test results are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): No information available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
STORAGE PRECAUTIONS:
You should store this chemical in an explosion-proof refrigerator
and keep it away from oxidizing materials. STORE AWAY FROM SOURCES
OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Seal the absorbent
paper, as well as any of your clothing which may be contaminated, in a vapor-
tight plastic bag for eventual disposal. Wash any surfaces you may have
contaminated with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
Not available
OTHER: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include eye, mucous membrane and upper
respiratory tract irritation.
SOURCES
SOURCES:
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. ET5500000.
Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 65th Ed. CRC Press, Inc. Boca Raton,
FL. 1984. p. C-206; #4351.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 4, p. 3776; #M01195.
Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 866; #5911.
Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 523.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 1821.
Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
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Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 672.
Bretherick, L. Handbook of Reactive Chemical Hazards. 3rd Ed.
Butterworths. London. 1985. p. 523.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
Oak Ridge National Laboratory. Environmental Teratogen Information
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Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 1224; #B.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1984. p. 728; #24,609-3.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 77.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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