NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000400
CAS NUMBER: 61-82-5
BASE CHEMICAL NAME: AMINOTRIAZOLE,3-,1,2,4-
PRIMARY NAME: 3-AMINO-1,2,4-TRIAZOLE
CHEMICAL FORMULA: C2H4N4
STRUCTURAL FORMULA: Not printable
WLN: T5MN DNJ CZ
SYNONYMS:
S-TRIAZOLE, 3-AMINO-
AMEROL
AMINOTRIAZOLE
3-AMINO-S-TRIAZOLE
2-AMINO-1,3,4-TRIAZOLE
3-AMINO-1H-1,2,4-TRIAZOLE
AMITOL
AMITRIL
AMITROL
AMIZOL
ENT 25445
AZOLE
CYTROLE
AMITROLE
DIUROL 5030
DOMATOL
EMISOL
TRIAZOLAMINE
VOROX
USAF XR-22
RAMIZOL
CYTROL
3-AMINOTRIAZOLE
3,A-T
ATA
AZAPLANT
FENAMINE
WEEDAR ADS
WEEDAZIN
WEEDOCLOR
2-AMINOTRIAZOLE
AMINO TRIAZOLE WEEDKILLER 90
AMINOTRIAZOL-SPRITZPULVER
AT
AZAPLANT KOMBI
AZOLAN
CAMPAPRIM A 1544
ELMASIL
HERBIDAL TOTAL
HERBIZOLE
KLEER-LOT
ORGA-414
RADOXONE TL
SIMAZOL
WEEDAZOL
WEEDEX GRANULAT
X-ALL LIQUID
AMINOTRIAZOLE (PLANT REGULATOR)
AMITRIL T.L.
AMITROL 90
AMITROL-T
AMIZOL D
AMIZOL DP NAU
AMIZOL F
AT-90
AT LIQUID
CYTROL AMITROLE-T
DIUROL
DOMATOL 88
EMISOL 50
EMISOL F
FENAVAR
RCRA WASTE NUMBER U011
SOLUTION CONCENTREE T271
1H-1,2,4-TRIAZOL-3-AMINE
VOROX AA
VOROX AS
WEEDAR AT
WEEDAZIN ARGINIT
WEEDAZOL GP2
WEEDAZOL SUPER
WEEDAZOL T
WEEDAZOL TL
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White crystals
REPOSITORY: White powder
MOLECULAR WEIGHT: 84.08
SPECIFIC GRAVITY: Not available
DENSITY: 1.138 @ 20 C [169]
MP (DEG C): 159 [016,058,395,430]
BP (DEG C): Not available
SOLUBILITIES:
WATER : >=100 mg/mL @ 17.5 C (RAD)
DMSO : >=100 mg/mL @ 17.5 C (RAD)
95% ETHANOL : 5-10 mg/mL @ 17.5 C (RAD)
METHANOL : Soluble [033]
ACETONE : 1-5 mg/mL @ 17.5 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Soluble [016,062,421,430]
Non-polar solvents: Insoluble [172,173]
Chloroform: Soluble [016,033,421,430]
Ethyl acetate: Sparingly soluble [033,395]
Ether: Insoluble [033,172,395,421]
VOLATILITY:
Vapor pressure: 0.000000441 mm Hg @ 20 C [058]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Literature sources indicate that this compound is non-combustible [058].
Fires involving this chemical can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher. A water spray may also be used [269].
UEL: Not available LEL: Not available
REACTIVITY:
This compound forms chelates with some metals. It is corrosive to iron,
copper and aluminum [071,169,172]. Forms salts with most acids and alkalies
[169,172]. This compound is incompatible with strong oxidizers, strong acids,
acid chlorides and acid anhydrides [269].
STABILITY:
This compound is sensitive to moisture [058]. UV spectrophotometric
stability screening indicates that solutions of this compound in 95% ethanol
are stable for at least 24 hours (RAD).
OTHER PHYSICAL DATA:
Sublimes undecomposed at reduced pressure [071]
Bitter taste [430]
Odorless [173]
pH (10% solution): 6.5-7.5 [058]
log P octanol: 0.52 [395]
TOXICITY
NIOSH REGISTRY NUMBER: XZ3850000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl mus 14700 mg/kg
LD50 orl rat 1100 mg/kg
LD50 ipr mus 200 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by intraperitoneal. Moderately toxic by ingestion. An experi-
mental carcinogen, tumorigen, neoplastigen and teratogen. Other experi-
mental reproductive effects. Mutagenic data.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 4595 mg/kg/2.5Y-C
TDLo: orl-mus 113 gm/kg/3W-I
TD : orl-rat 3670 mg/kg/2Y-C
TD : orl-rat 122 gm/kg/70W-C
TD : orl-rat 105 gm/kg/60W-C
TD : orl-mus 366 gm/kg/26W-C
Review: IARC Cancer Review: Animal Sufficient Evidence
IARC Cancer Review: Human Inadequate Evidence
IARC possible human carcinogen (Group 2B) [015,395,610]
Status: NTP Fourth Annual Report on Carcinogens, 1984
NTP anticipated human carcinogen [610]
EPA Carcinogen Assessment Group [610]
MUTATION DATA: See RTECS printout for data
TERATOGENICITY: See RTECS printout for data
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Final Limits: PEL-TWA: 0.2 mg/m3 [015,545,610]
ACGIH: TLV-TWA: 0.2 mg/m3 [015,415,421,610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 1
Flammability (F): 1
Reactivity (R): 0
H1: Materials only slightly hazardous to health (see NFPA for details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Review: Toxicology Review-2
Status: EPA Genetox program 1988, Positive: Carcinogenicity-mouse/rat; SHE-
clonal assay
EPA Genetox program 1988, Positive: Cell transform.-RLV F344 rat
embryo; Host-mediated assay
EPA Genetox program 1988, Negative: D melanogaster-whole sex chrom.
loss
EPA Genetox program 1988, Negative: D melanogaster-nondisjunction;
N crassa-aneuploidy
EPA Genetox program 1988, Negative: E coli polA without S9; E coli
polA with S9
EPA Genetox program 1988, Negative: Histidine reversion-Ames test;
Sperm morphology-mouse
EPA Genetox program 1988, Negative: In vitro UDS-human fibroblast;
S cerevisiae-homozygosis
EPA Genetox program 1988, Inconclusive: Mammalian micronucleus
EPA Genetox program 1988, Inconclusive: D melanogaster Sex-linked
lethal
EPA TSCA Chemical Inventory, 1986
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This compound is used as a defoliant, a herbicide, a reagent in photo-
graphy and a plant growth regulator. It is used in non-selective weed control.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
When heated to decomposition this compound emits toxic fumes of carbon
monoxide, carbon dioxide and oxides of nitrogen [043,058,269]. It is poison by
intraperitoneal and moderately toxic by ingestion [043]. It is harmful by skin
absorption and may be harmful by inhalation [269].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
PE/EVAL/PE Safety 4 4H 0.07 mm 240 min
Butyl rubber North B-174 0.63 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should keep this material in a tightly closed container
under an inert atmosphere, and store it at refrigerated temperatures.
SPILLS AND LEAKAGE:
If you spill this chemical, you should dampen the solid spill material
with water,then transfer the dampened material to a suitable container. Use
absorbent paper dampened with water to pick up any remaining material. Seal
your contaminated clothing and the absorbent paper in a vapor-tight plastic
bag for eventual disposal. Wash all contaminated surfaces with a soap
and water solution. Do not reenter the contaminated area until the Safety
Officer (or other responsible person) has verified that the area has been
properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include irritation of the eyes,
skin and upper respiratory tract, depression, dyspnea, labored respiration,
diarrhea, ataxia, vomiting, convulsions, coma, lung injury and, possibly,
thyroid effects [058]. It may also enhance yellowing or browning of lenses
with ultraviolet exposure [099].
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