NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000305
CAS NUMBER: 60-51-5
BASE CHEMICAL NAME: CYGON
PRIMARY NAME: CYGON
CHEMICAL FORMULA: C5H12NO3PS2
STRUCTURAL FORMULA: (CH3O)2PSSCH2CONHCH3
WLN: 1OPS&O1&S1VM1
SYNONYMS:
PHOSPHORODITHIOIC ACID, O,O-DIMETHYL ESTER, S-ESTER WITH 2-MERCAPTO-N-
METHYLACETAMIDE
ACETIC ACID, O,O-DIMETHYLDITHIOPHOSPHORYL-, N-MONOMETHYLAMIDE SALT
O,O-DIMETHYLDITHIOPHOSPHORYLACETIC ACID, N-MONOMETHYLAMIDE SALT
O,O-DIMETHYL S-(2-(METHYLAMINO)-2-OXOETHYL) PHOSPHORODITHIOATE
O,O-DIMETHYL S-(N-METHYLCARBAMYLMETHYL) THIOTHIONOPHOSPHATE
O,O-DIMETHYL METHYLCARBAMOYLMETHYL PHOSPHORODITHIOATE
O,O-DIMETHYL S-(N-METHYLCARBAMOYLMETHYL) DITHIOPHOSPHATE
O,O-DIMETHYL S-(N-METHYLCARBAMOYLMETHYL) PHOSPHORODITHIOATE
O,O-DIMETHYL-S-(N-MONOMETHYL)-CARBAMYL METHYL DITHIOPHOSPHATE
S-METHYLCARBAMOYLMETHYL O,O-DIMETHYL PHOSPHORODITHIOATE
N-MONOMETHYLAMIDE OF O,O-DIMETHYLDITHIOPHOSPHORYLACETIC ACID
PHOSPHORODITHIOIC ACID, O,O-DIMETHYL-S-(2-(METHYLAMINO)-2-OXOETHYL) ESTER
AC-12880
AMERICAN CYANAMID 12880
BI-58
AC-18682
BI 58 EC
8014 BIS HC
CEKUTHOATE
CL 12880
CYGON 2-E
CYGON 4E
CYGON INSECTICIDE
DAPHENE
DE-FEND
DEMOS-L40
DEVIGON
DIMATE 267
DIMET
DIMETATE
DIMETHOATE
DIMETHOATE-267
DIMETHOAT TECHNISCH 95%
DIMETHOGEN
DIMETON
DIMEVUR
FOSFAMID
FOSFOTOX
NC-262
EI-12880
ENT 24,650
EXPERIMENTAL INSECTICIDE 12,880
FERKETHION
FIP
FORTION NM
FOSFOTOX R
FOSFOTOX R 35
FOSTION MM
L-395
LURGO
OMS 94
OMS 111
PEI 75
PERFECTHION
PERFEKTHION
PERFEKTION
PHOSPHAMID
PHOSPHAMIDE
RACUSAN
RCRA WASTE NUMBER P044
REBELATE
ROGODIAL
ROGOR
ROGOR 40
ROGOR L
ROGOR 20L
ROGOR P
ROXION
ROXION U.A.
SINORATOX
TRIMETION
NCI-C00135
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White crystalline solid
REPOSITORY: White crystals
MOLECULAR WEIGHT: 229.28
SPECIFIC GRAVITY: 1.281 @ 50 C [173]
DENSITY: 1.281 g/mL @ 50 C [172]
MP (DEG C): 51-52 C [027,169,172,173]
BP (DEG C): 117 C @ 0.1 mm Hg [169]
SOLUBILITIES:
WATER : 1-10 mg/mL @ 24 C (RAD)
DMSO : <1 mg/mL @ 19 C (RAD)
95% ETHANOL : >=100 mg/mL @ 21 C (RAD)
METHANOL : Not available
ACETONE : <1 mg/mL @ 21 C (RAD)
TOLUENE : Soluble [169,172]
OTHER SOLVENTS:
Most organics: Soluble [033,062,173,430]
Chloroform: >300 g/kg @ 20 C [172]
Dichloromethane: >300 g/kg @ 20 C [172]
Ketones: >300 g/kg @ 20 C [172]
Carbon tetrachloride: >50 g/kg @ 20 C [172]
Octan-1-ol: >50 g/kg @ 20 C [172]
Benzene: >300 g/kg @ 20 C [172]
Alcohols: >300 g/kg @ 20 C [172]
Aliphatic hydrocarbons: Slightly soluble [169,430]
Saturated hydrocarbons: >50 g/kg @ 20 C [172]
Xylene: Slightly soluble [169]
VOLATILITY:
Vapor pressure: 0.025 mm Hg @ 25 C [055]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 130-132 C (266-270 F) [430]. It is
combustible. Fires involving this chemical can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This compound is incompatible with alkaline preparations [169,172]. It is
slightly corrosive to iron. It is incompatible with sulfur based formulations
[169].
STABILITY:
This chemical is stable under normal laboratory conditions. It is stable
in aqueous solution but is hydrolyzed by aqueous alkali [033,169,172,186].
Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be
stable for 24 hours under normal laboratory conditions (RAD). This compound
decomposes when heated above 170 C [430].
OTHER PHYSICAL DATA:
Camphor-like odor [173]
Refractive index: 1.5334 @ 65 C [033,169,172]; 1.5377 @ 50 C [430]
log P octanol: 2.71 [055]
Vapor pressure also reported as 0.0000085 mm Hg @ 25 C [173]
TOXICITY
NIOSH REGISTRY NUMBER: TE1750000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl hmn 30 mg/kg
TDLo orl man 286 mg/kg
TDLo orl man 300 mg/kg
LD50 orl rat 60 mg/kg
LD50 skn rat 353 mg/kg
LD50 ipr rat 100 mg/kg
LD50 scu rat 350 mg/kg
LD50 ivn rat 450 mg/kg
LD50 unr rat 215 mg/kg
LD50 orl mus 60 mg/kg
LD50 ipr mus 45 mg/kg
LD50 scu mus 60 mg/kg
LD50 orl dog 400 mg/kg
LD50 orl cat 100 mg/kg
LD50 orl rbt 300 mg/kg
LD50 orl gpg 350 mg/kg
LDLo ipr gpg 750 mg/kg
LD50 orl ham 200 mg/kg
LD50 scu ham 60 mg/kg
LD50 orl ckn 25 mg/kg
LD50 orl qal 25 mg/kg
LD50 orl dck 42 mg/kg
LD50 orl bwd 6600 ug/kg
LD50 skn rbt 1 gm/kg
LD50 ipr ham 160 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion, skin contact, intraperitoneal, subcutaneous and
possibly other routes. Moderately toxic by intravenous route. An
experimental carcinogen and teratogen. Experimental reproductive
effects. Human mutagenic data.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 256 mg/kg/4W-I
TDLo: ims-rat 176 mg/kg/6W-I
Status: NCI Carcinogenesis Bioassay (Feed); Negative: Male and Female Rat,
Male and Female Mouse [015,620]
MUTATION DATA: See RTECS printout for data
TERATOGENICITY: See RTECS printout for data
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Review: Toxicology Review-7
Status: EPA Genetox Program 1988, Positive: S cerevisiae gene conversion
EPA Genetox Program 1988, Negative: Carcinogenicity-mouse/rat
EPA Genetox Program 1988, Negative: D melanogaster Sex-linked lethal
EPA Genetox Program 1988, Inconclusive: B subtilis rec assay
EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, January 1990
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Organophosphorus pesticides, solid, toxic, n.o.s.
UN/ID NUMBER: UN2783
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 619, Y619 MAXIMUM QUANTITY: 100 kg, 10 kg
CARGO : PKG. INSTR.: 619 MAXIMUM QUANTITY: 200 kg
SPECIAL PROVISIONS: None
USES:
This chemical is a broad range contact and systemic acaricide and insect-
icide. It is also used in the control of bots in livestock.
COMMENTS:
Use of this compound has been resticted [062]. This compound becomes more
toxic when heated or stored [173].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is a CHOLINESTERASE INHIBITOR [033,099,169,566]. When heat-
ed to decomposition it emits very toxic fumes of carbon oxides, nitrogen ox-
ides, phosphorous oxides and sulfer oxides [043,566]. It is toxic by inges-
tion, intraperitoneal, subcutaneous and possibly other routes [043].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Neoprene Edmont 29-870 0.48 mm 240 min
Nitrile Edmont 37-175 0.65 mm 240 min
Natural rubber Ansell Conform 4205 0.13 mm 120 min
Natural + Neoprene Ansell Omni 276 0.56 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material under ambient temperatures.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
CHOLINESTERASE INHIBITORS ARE EXTREMELY TOXIC AND FAST-ACTING POISONS.
IMMEDIATELY call a hospital of poison control center and transport the victim
to a hospital. Atropine is an antidote for cholinesterase inhibitors but
should only be administered by properly trained personnel. In the absence of
this option and if the victim is conscious and not convulsing, it may be worth
considering the risk of inducing vomiting, even though the induction of
vomiting is not usually recommended outside of a physician's care. Ipecac
syrup or salt water may be used to induce vomiting in such an emergency.
If the victim is convulsing or unconscious, do not give anything by mouth,
assure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
This compound is a cholinesterase inhibitor [033,062,295,566]. It is
generally not irritating to the eyes or skin [099,173]. Symptoms of exposure
to this compound are vomiting, diarrhea, unconsciousness, pinpoint pupils,
coarse ronchi and rales in the chest and death [173]. Symptoms of exposure to
this class of chemical include unequal miosis, hyperemia of the conjunctiva,
dimness of vision, rhinorrhea, frontal headache, bronchoconstriction, increased
bronchial secretion, cough, nausea, fasiculations and sweating at the site of
contact, anorexia, abdominal cramps, incontinence, eye changes, weakness,
dyspnea, bronchospasm, lacrymation, increased salivation and sweating, brady-
cardia, hypotension or hypertension, asphyxia, cyanosis, muscular twitching of
the eyelids, tongue, face and neck, convulsions, restlessness, anxiety, dizzi-
ness, tremor, ataxia, depression, confusion and coma [295].
SOURCES
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