NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
4-DIMETHYLAMINOAZOBENZENE
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IDENTIFIERS
CATALOG ID NUMBER: 000409
CAS NUMBER: 60-11-7
BASE CHEMICAL NAME: DIMETHYLAMINOAZOBENZENE,4-
PRIMARY NAME: 4-DIMETHYLAMINOAZOBENZENE
CHEMICAL FORMULA: C14H15N3
STRUCTURAL FORMULA: C6H5N=NC6H4N(CH3)2
WLN: 1N1&R DNUNR
SYNONYMS:
N,N-DIMETHYL-P-PHENYLAZOANILINE
P-DIMETHYLAMINOAZOBENZENE
N,N-DIMETHYL-4-(PHENYLAZO)BENZENAMINE
BENZENEAZODIMETHYLANILINE
C.I. SOLVENT YELLOW 2
METHYL YELLOW
DIMETHYLAMINOAZOBENZENE
N,N-DIMETHYL-4-AMINOAZOBENZENE
N,N-DIMETHYL-P-AMINOAZOBENZENE
4-(N,N-DIMETHYLAMINO)AZOBENZENE
DIMETHYLAMINOAZOBENZOL
4-DIMETHYLAMINOAZOBENZOL
4-DIMETHYLAMINOPHENYLAZOBENZENE
N,N-DIMETHYL-P-AZOANILINE
N,N-DIMETHYL-4-(PHENYLAZO)BENZAMINE
ATUL FAST YELLOW R
BRILLIANT FAST OIL YELLOW
BRILLIANT FAST SPIRIT YELLOW
BRILLIANT OIL YELLOW
BUTTER YELLOW
CERASINE YELLOW GG
C.I. 11020
DAB
DAB (CARCINOGEN)
DIMETHYL YELLOW
DIMETHYL YELLOW ANALAR
DIMETHYL YELLOW N,N-DIMETHYLANILINE
DMAB
ENIAL YELLOW 2G
FAST OIL YELLOW B
FAST YELLOW
FAT YELLOW
FAT YELLOW A
FAT YELLOW AD OO
FAT YELLOW ES
FAT YELLOW ES EXTRA
FAT YELLOW EXTRA CONC.
FAT YELLOW R
FAT YELLOW R (8186)
GRASAL BRILLIANT YELLOW
OIL YELLOW
OIL YELLOW II
OIL YELLOW 20
OIL YELLOW 2625
OIL YELLOW 7463
OIL YELLOW BB
OIL YELLOW D
OIL YELLOW DN
OIL YELLOW FF
OIL YELLOW FN
OIL YELLOW G
OIL YELLOW 2G
OIL YELLOW G-2
OIL YELLOW GG
OIL YELLOW GR
OIL YELLOW N
OIL YELLOW PEL
OLEAL YELLOW 2G
ORGANOL YELLOW ADM
ORIENT OIL YELLOW GG
P.D.A.B.
PETROL YELLOW WT
RCRA WASTE NUMBER U093
RESINOL YELLOW GR
RESOFORM YELLOW GGA
SILOTRAS YELLOW T2G
SOMALIA YELLOW A
STEAR YELLOW JB
SUDAN GG
SUDAN YELLOW
SUDAN YELLOW GG
SUDAN YELLOW GGA
TOYO OIL YELLOW G
USAF EK-338
WAXOLINE YELLOW AD
WAXOLINE YELLOW ADS
YELLOW G SOLUBLE IN GREASE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Yellow crystalline leaflets
REPOSITORY: Orange powder
MOLECULAR WEIGHT: 225.30
SPECIFIC GRAVITY: Not available
DENSITY: Not available
MP (DEG C): 111 C (decomposes) [055,269,274]
BP (DEG C): Not available
SOLUBILITIES:
WATER : <1 mg/mL @ 22 C (RAD)
DMSO : 5-10 mg/mL @ 22 C (RAD)
95% ETHANOL : <1 mg/mL @ 22 C (RAD)
METHANOL : Not available
ACETONE : 50-100 mg/mL @ 22 C (RAD)
P TOLUENE : 1.2-3 g/100 mL @ room temperature [105]
OTHER SOLVENTS:
Benzene: 2.8 g/100 mL @ room temperature [105]
Ether: Soluble [031,062,205,395]
Mineral acids: Soluble [031,042,062,395]
Oils: Soluble [031,042,062,395]
Chloroform: Soluble [031,205,395]
Petroleum ether: Soluble [031,205,395]
Cellosolve: Soluble [105]
Ethyl acetate: 2 g/100 mL @ room temperature [105]
Linseed oil: 2.6-5 g/100 mL @ room temperature [105]
Mineral oil: 0.1-1 g/100 mL @ room temperature [105]
Oleic acid: 1.5-4.2 g/100 mL @ room temperature [105]
Paraffin wax: 0.5-2 g/100 mL @ room temperature [105]
Stearic acid: 1.5-10 g/100 mL @ room temperature [105]
Turpentine: Soluble [105]
White spirit: 0.4-1.5 g/100 mL @ room temperature [105]
Xylene: 0.75-1.65 g/100 mL @ room temperature [105]
VOLATILITY:
Vapor pressure: Not available
Vapor density : 7.78
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available. It is probably
combustible. Fires involving this material can be controlled with a
dry chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong oxidizing agents and strong acids
[269].
STABILITY:
This chemical is sensitive to heat and light [051]. Solutions of this
chemical in water, DMSO, 95% ethanol or acetone should be stable for 24
hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
log P octanol: 4.58
Yellow solution in concentrated sulfuric acid; on dilution-red solution
Red solution in hydrochloric acid, from which the hydrochloride crystallizes
in purple-red, hair-like needles; the base separates as an orange precipitate
on addition of sodium hydroxide
TOXICITY
NIOSH REGISTRY NUMBER: BX7350000
TOXICITY:
typ. dose mode specie amount units other
LD50 ipr mus 230 mg/kg
LD50 ipr rat 230 mg/kg
LD50 orl mus 300 mg/kg
LD50 orl rat 200 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: MUTATION data. An experimental teratogen, carcinogen, neoplastigen
and equivocal tumorigenic agent. HIGH via oral and intraperitoneal routes.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: ipr-mus 3830 ug/kg
TD : ipr-mus 11 mg/kg
TDLo: mlt-mus 400 mg/kg/I
TDLo: orl-dog 9600 mg/kg/69W-C
TDLo: orl-ham 9600 mg/kg/42W-I
TDLo: orl-rat 5426 mg/kg/17W-C
TD : orl-rat 2600 mg/kg/13W-C
TD : orl-rat 13 gm/kg/53W-C
TD : orl-rat 1920 mg/kg/14W-C
TD : orl-rat 1800 mg/kg/14W-C
TD : orl-rat 2331 mg/kg/7W-I
TD : orl-rat 17200 mg/kg/17W-C
TD : orl-rat 8316 mg/kg/33W-C
TD : orl-rat 3990 mg/kg/19W-C
TD : orl-rat 800 mg/kg/64D-C
TDLo: scu-mus 4000 mg/kg (15-21D preg)
TDLo: skn-rat 1440 mg/kg/90W-I
Review: IARC Cancer Review: Animal Sufficient Evidence
IARC possible human carcinogen (Group 2B) [610]
Status: EPA Carcinogen Assessment Group [610]
OSHA cancer suspect agent [610]
NTP Fourth Annual Report on Carcinogens, 1984
NTP anticipated human carcinogen [610]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
bfa-rat/sat 600 mg/kg | mrc-smc 5 mg/L
cyt-rat-orl 756 mg/kg/3W | hma-mus/sat 255 mg/kg/3H
dnd-mus-ipr 120 mg/kg | msc-mus:lym 89 umol/L
dnd-mus-skn 192 umol/kg | mnt-mus-ipr 6400 ug/kg
dnd-rat-orl 300 mg/kg | mmo-sat 5 mg/plate
dnd-rat-ipr 150 mg/kg | mma-esc 200 mg/L
dni-hmn:hla 100 umol/L | mma-sat 50 ug/plate
dni-mus-ipr 20 gm/kg | otr-ham-ipr 500 mg/kg
dni-mus-orl 100 mg/kg | otr-ham:emb 50 ug/L
dnr-esc 80 mg/L | otr-ham:kdy 25 mg/L
dnr-smc 600 mg/L | otr-mus:emb 89 umol/L
dns-ham:lvr 1 umol/L | otr-nml:oth 250 ug/L
dns-hmn:hla 10 nmol/L | otr-rat:emb 12 mg/L
dns-hmn:fbr 4 mg/L | sln-smc 50 mg/L
dns-mus:lvr 1 umol/L | sce-mus-ipr 29 mg/kg
dns-rat:lvr 10 umol/L | spm-mus-ipr 3 gm/kg/5D-I
TERATOGENICITY:
Reproductive Effects Data:
TDLo: ipr-mus 3 gm/kg (5D male)
TDLo: scu-mus 200 mg/kg (10D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: See Carcinogenicity
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Review: Toxicology Review-5
Status: EPA Genetox Program 1986, Positive: Cell transform.-RLV F344 rat
embryo
EPA Genetox Program 1986, Positive: Mammalian micronucleus; Histidine
reversion-Ames test
EPA Genetox Program 1986, Positive: Body fluid assay; Carcinogenicity-
mouse/rat
EPA Genetox Program 1986, Negative: Cell transform.-BALB/c-3T3; E coli
polA with S9
EPA Genetox Program 1986, Negative: Sperm morphology-mouse; S
cerevisiae-homozygosis
EPA Genetox Program 1986, Inconclusive: SHE-clonal assay; B subtilis
rec assay
EPA Genetox Program 1986, Inconclusive: E coli polA without S9
EPA Genetox Program 1986, Inconclusive: D melanogaster Sex-linked
lethal
EPA Genetox Program 1986, Inconclusive: In vitro UDS-human fibroblast
EPA TSCA Chemical Inventory, 1986
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Poisonous solids, n.o.s.
(4-Dimethylaminoazobenzene)
UN/ID NUMBER: UN2811
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 619, Y619 MAXIMUM QUANTITY: 100 kg, 10 kg
CARGO : PKG. INSTR.: 619 MAXIMUM QUANTITY: 200 kg
SPECIAL PROVISIONS: None
USES:
Dye (for polishes and other wax products, polystyrene, petrol and soap);
indicator in volumetric analysis (yellow @ pH 4.0; red @ pH 2.9); for the
determination of free HCl in gastric juice; spot test identification of
peroxidized fats; and formerly as a food dye.
COMMENTS:
The FDA prohibits its use in foods or beverages.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is harmful by ingestion, inhalation or skin absorption [269].
There is sufficient evidence that it is carcinogenic in animals [015,269,395].
It is an OSHA carcinogen [015,051,269,325]. When heated to decomposition it
emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides [042,
269].
MINIMUM PROTECTIVE CLOTHING: P
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES Expert System Recommended Gloves For Use With Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES expert system was used to extrapolate permeation test
information from compounds in the same chemical class and the following
recommendation(s) are provided. The GlovES system uses permeation data from
literature sources; therefore, extra safety margins should be used with the
recommended exposure times. If this chemical comes into contact with your
glove, or if a tear, puncture or hole develops, remove them at once.
Suggested Glove Type Model Number Thickness Estimated Breakthrough
Polyvinyl alcohol Edmont 25-545 0.63 mm 240 min.
Nitrile Edmont 37-165 0.60 mm 120 min.
Viton North F-091 0.25 mm 240 min.
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should protect this material from exposure to light, and store
it in a refrigerator.
SPILLS AND LEAKAGE:
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION,
then you should dampen the solid spill material with acetone and transfer the
dampened material to a suitable container. Use absorbent paper dampened with
acetone to pick up any remaining material. Seal your contaminated clothing
and the absorbent paper in a vapor-tight plastic bag for eventual disposal.
Solvent wash all contaminated surfaces with acetone followed by washing with
a soap and water solution. Do not reenter the contaminated area until the
Safety Officer (or other responsible person) has verified that the area has
been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include contact dermatitis [051,
395]. Mammals exposed to lethal doses have developed damage to the liver
and kidneys. Methemoglobinemia is caused by most of the compounds in this
class and this can produce asphyxia with resultant damage to cells of the
central nervous system [051].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. BX7350000.
[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 2, p. 2059, #D-05463.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 470, #3220.
[042] Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. pp. 1188-1189.
[051] Sax, N. Irving, Ed. Dangerous Properties of Industrial Materials
Report. Bi-monthly Updates. Van Nostrand Reinhold Company, Inc.
New York. May/June 1985; Vol. 5, No. 3, pp. 48-51.
[055] Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
pp. 544-545.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 410.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[105] The Society of Dyers and Colourists. Colour Index. Vols. 1-7.
The Society of Dyers and Colourists. Yorkshire, England.
American Association of Textile Chemists and Colorists.
Research Triangle Park, NC. 1971-1982. Vol. 3, pp. 3566-3567;
Vol. 4, p. 4014.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-542, #m858.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 1325, #A.
[274] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1986. p. 274, #11,449-9.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. p. 154.
[325] Office of the Federal Register National Archives and Records
Administration. Code of Federal Regulations, Title 29, Labor,
Parts 1900 to 1910. U.S. Government Printing Office.
Washington. 1986. pp. 757-762.
[346] Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
2nd Ed. Noyes, Publications. Park Ridge, NJ. 1985. pp. 361-362.
[395] International Agency for Research on Cancer, World Health
Organization. IARC Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man. International
Agency for Research on Cancer. Geneva. 1971-1982.
Vol. 8, pp. 125-146.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xvii.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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