NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
2,3,4,6-TETRACHLOROPHENOL
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IDENTIFIERS
CATALOG ID NUMBER: 001352
CAS NUMBER: 58-90-2
BASE CHEMICAL NAME: TETRACHLOROPHENOL,2,3,4,6-
PRIMARY NAME: 2,3,4,6-TETRACHLOROPHENOL
CHEMICAL FORMULA: C6H2Cl4O
STRUCTURAL FORMULA: Cl4C6(H)OH
WLN: Not available
SYNONYMS:
DOWICIDE 6
TCP
2,4,5,6-TETRACHLOROPHENOL
PHENOL, 2,3,4,6-TETRACHLORO-
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: LITERATURE: Brown flakes
REPOSITORY: Beige solid
MOLECULAR WEIGHT: 231.89
SPECIFIC GRAVITY: 1.839 @ 25/4 C
DENSITY: Not available
MP (DEG C): 70 C
BP (DEG C): 150 C @ 15 mm Hg
SOLUBILITIES:
WATER : <1 mg/mL @ 20 C (RAD)
DMSO : >=100 mg/mL @ 20 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 20 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Soluble
Ligroin: Soluble
Benzene: Soluble
VOLATILITY:
Vapor pressure: 1 mm Hg @ 100.0 C; 60 mm Hg @ 190 C; 400 mm Hg @ 250 C
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Literature sources indicate that this compound is nonflammable. Fires
involving this material can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY: Not available
STABILITY:
This chemical is stable under normal laboratory conditions. Solutions of
this chemical in water, DMSO, 95% ethanol or acetone should be stable for
24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Needles (from ligroin or acetic acid)
Specific gravity: 1.6 @ 60/4 C
Strong odor
Boiling point: 164 C @ 23 mm Hg
TOXICITY
NIOSH REGISTRY NUMBER: SM9275000
TOXICITY:
typ. dose mode specie amount unit other
LD50 orl rat 140 mg/kg
LD50 ipr rat 130 mg/kg
LDLo scu rat 210 mg/kg
LDLo ipr mus 250 mg/kg
LD50 skn rbt 250 mg/kg
LD50 orl gpg 250 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: An experimental carcinogen. HIGH via oral, intraperitoneal, subcutaneous
and skin routes.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: scu-mus 100 mg/kg
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
Not available |
TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-rat 300 mg/kg (6-15D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Status: Reported in EPA TSCA Inventory, 1983
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Poisonous solids, n.o.s.
(2,3,4,6-Tetrachlorophenol)
UN/ID NUMBER: UN2811
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 619, Y619 MAXIMUM QUANTITY: 100 kg, 10 kg
CARGO : PKG. INSTR.: 619 MAXIMUM QUANTITY: 200 kg
SPECIAL PROVISIONS: None
USES:
Fungicide.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by ingestion and inhalation. It is an irritant of the
skin, eyes, nose and pharynx. When heated to decomposition it emits toxic
fumes of Cl-. It is an experimental carcinogen.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemical:
Recommendations based on permeation test results are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): No information available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material at ambient temperatures.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Phenols are very toxic poisons AND corrosive
and irritating, so that inducing vomiting may make medical problems worse.
IMMEDIATELY call a hospital or poison control center and locate activated
charcoal, egg whites, or milk in case the medical advisor recommends admini-
stering one of them.
If advice from a physician is not readily available and the victim is
conscious and not convulsing, give the victim a glass of activated charcoal
slurry in water or, if this is not available, a glass of milk, or beaten egg
whites and IMMEDIATELY transport victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
assure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include irritation of the skin,
eyes, nose, and pharynx; conjunctivitis, corneal injuries, and dermatitis
with repeated skin contact. Symptoms of exposure to phenols (through
ingestion or contact with the skin or mucous membranes) may include pain-
less blanching or erythema, possible corrosion, profuse sweating, intense
thirst, nausea and vomiting, diarrhea, cyanosis from methemoglobinemia,
hyperactivity; stupor; blood pressure fall; hyperpnea; abdominal pain;
hemolysis; convulsions; coma; and pulmonary edema followed by pneumonia.
If death from respiratory failure is not immediate, jaundice and oliguria
or anuria may occur. Skin sensitivity occasionally occurs.
SOURCES
SOURCES:
Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 65th Ed. CRC Press, Inc. Boca Raton,
FL. 1984. p. C-438, #11014.
Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 523.
Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. II, p. 72, #P01277.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. pp. 402-405.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. SM9275000.
Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. p. II-195, #534.
Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. 1983. Listed.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 5, p. 5149, #T-00453.
Verschueren, K. Handbook of Environmental Data on Organic Chemicals.
2nd Ed. Van Nostrand Reinhold. New York. pp. 1081-1082.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 1003.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 2519.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xvii.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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