NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001326
CAS NUMBER: 583-39-1
BASE CHEMICAL NAME: MERCAPTOBENZIMIDAZOLE,2-
PRIMARY NAME: 2-MERCAPTOBENZIMIDAZOLE
CHEMICAL FORMULA: C7H6N2S
STRUCTURAL FORMULA: Not printable
WLN: T56 BM DNJ CSH
SYNONYMS:
2-BENZIMIDAZOLETHIOL
MERCAPTOBENZOIMIDAZOLE
2-MERCAPTOBENZOIMIDAZOLE
O-PHENYLENETHIOUREA
1,3-DIHYDRO-2H-BENZIMIDAZOLE-2-THIONE
MERCAPTOBENZIMIDAZOLE
2-BENZIMIDAZOLINETHIONE
1H-BENZIMIDAZOLE-2-THIOL
2-THIOBENZIMIDAZOLE
ANTIOXIDANT MB
ANTIEGENE MB
AOMB
ASM MB
USAF EK-6540
USAF XF-21
NCI-C60980
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Yellow to white crystals
REPOSITORY: Cream colored powder
MOLECULAR WEIGHT: 150.21
SPECIFIC GRAVITY: 1.42 [058]
DENSITY: Not available
MP (DEG C): 303-304 C [031,052,205]
BP (DEG C): Not available
SOLUBILITIES:
WATER : <1 mg/mL @ 23.5 C (RAD)
DMSO : >=100 mg/mL @ 23.5 C (RAD)
95% ETHANOL : 1-10 mg/mL @ 23.5 C (RAD)
METHANOL : Soluble [031]
ACETONE : 10-50 mg/mL @ 23.5 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Absolute ethanol: Soluble [052]
VOLATILITY:
Vapor pressure: 30.2 mm Hg @ 61 C [600]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also
be used [058].
UEL: Not available LEL: Not available
REACTIVITY: Not available
STABILITY:
This chemical is moisture sensitive [058]. UV spectrophotometric
stability screening indicates that solutions of this compound in DMSO are
stable for at least 24 hours (RAD).
OTHER PHYSICAL DATA:
Dust explosion: 0.140 oz/ft3 [600]
Lambda max: 304 nm, 298 nm (shoulder), 247 nm, 218 nm (epsilon = 0.0002938,
0.0002461, 0.0001487, 0.0001684) [052]
Slight odor [058]
% Volatile by volume: Negligible [058]
TOXICITY
NIOSH REGISTRY NUMBER: DE1050000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl mus 750 mg/kg
LD50 ipr mus 200 mg/kg
LD50 ivn mus 180 mg/kg
LD50 orl rat 1230 mg/kg [058]
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by intraperitoneal and intravenous routes. Moderately toxic by
ingestion. A skin and eye irritant.
CARCINOGENICITY:
Status: NTP Carcinogenesis Studies; on test (prechronic studies), October 1988
MUTATION DATA:
test lowest dose | test lowest dose
---------- ---------------- | ---------- -----------------
Not available |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 500 mg/24H MLD
eye-rbt 500 mg/24H MLD
Status: EPA TSCA Chemical Inventory, 1986
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES: Not available
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
When heated to decomposition this compound emits very toxic fumes of
sulfur oxides and nitrogen oxides [042,053]. Inhalation of the dust may
cause respiratory tract irritation [058].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
PE/EVOH/PE Safety 4 4H 0.07 mm 240 min.
PVA Edmont 15-552 0.60 mm 240 min.
Viton North F-091 0.25 mm 240 min.
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should protect this material from exposure to moisture. Keep it in a
tightly closed container under inert atmosphere and store it under ambient
temperatures.
SPILLS AND LEAKAGE:
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION,
then you should dampen the solid spill material with acetone and transfer the
dampened material to a suitable container. Use absorbent paper dampened with
acetone to pick up any remaining material. Seal your contaminated clothing
and the absorbent paper in a vapor-tight plastic bag for eventual disposal.
Solvent wash all contaminated surfaces with acetone followed by washing with
a soap and water solution. Do not reenter the contaminated area until the
Safety Officer (or other responsible person) has verified that the area has
been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Inhalation of the dust of this compound may cause respiratory tract
irritation, resulting in runny nose, sneezing, coughing and chest discomfort
[058].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. DE1050000.
April 11, 1989.
[017] Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 67th Ed. CRC Press, Inc. Boca Raton,
FL. 1986. p. C-125, #2497.
[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 1, p. 544, #B-00247.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 154, #1083.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. 1, p. 380, #BCC500.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 205, #B01361.
[052] Midwest Research Institute. MRI Report for 2-Mercaptobenzimidazole.
Kansas City, MO. June 10, 1982; September 27, 1982.
[053] Arthur D. Little, Inc. Health and Safety Package for
2-Mercaptobenzimidazole. Arthur D. Little, Inc. Cambridge, MA.
March 3, 1982.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. April/May 1989.
#5833-342, A-07.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-476, #m27.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 945, #M320-5.
[600] Hazards Research Corporation. Vapor Pressure Determinations for
2-Mercaptobenzimidazole. HRC Report 5913A. Hazards Research
Corporation. Rockaway, NJ. April 19, 1985.
[610] Clansky, Kenneth B., ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 73.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
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