NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000632
CAS NUMBER: 57-13-6
BASE CHEMICAL NAME: UREA
PRIMARY NAME: UREA
CHEMICAL FORMULA: CH4N2O
STRUCTURAL FORMULA:
WLN: ZVZ
SYNONYMS:
CARBAMIDE
CARBONYLDIAMINE
NCI-C02119
CARBONYL DIAMIDE
AQUADRATE
UREAPHIL
UREOPHIL
CARBAMIMIDIC ACID
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: White crystals or powder.
MOLECULAR WEIGHT: 60.07
SPECIFIC GRAVITY: 1.3230 @ 20/4 C
DENSITY:Not available
MP (DEG C): 135 C
BP (DEG C): Decomposes
SOLUBILITIES:
WATER : SOLUBLE
DMSO : SOLUBLE
95% ETHANOL : SOLUBLE
METHANOL : Not available
ACETONE : Not available
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Insoluble
Methanol: 170 mg/mL
Acetic acid: Soluble
Pyrimidine: Soluble
Concentrated Hydrochloric acid: Soluble
ETHER : Slightly soluble
BENZENE: Insoluble
VOLATILITY :
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available, however it is probably
non-flammable. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY: Reacts violently with gallium perchlorate.
STABILITY: This compound will slowly hydrolyze.
OTHER PHYSICAL DATA: Refractive index: 1.484
TOXICITY
NIOSH REGISTRY NUMBER: YR6250000
TOXICITY:
typ. dose mode specie amount unit other
LDLO ORL DOM 511 MG/KG
LDLO SCU DOG 3000 MG/KG
LDLO IVN DOG 3000 MG/KG
LDLO SCU RBT 3000 MG/KG
LDLO IVN RBT 4800 MG/KG
LDLO SCU PGN 16 G/KG
LDLO SCU FRG 600 MG/KG
AQTX/TLM96: OVER 1000 PPM.
SAX TOXICITY EVALUATION: THR=MOD VIA SC, IV AND ORAL ROUTE.
CARCINOGENICITY: Not available
MUTAGENICITY: Not available
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA: Not available
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
Fertilizer, animal fedd, plastics, chemical intermediate, stabilizer
in explosives, medicine, adhesives, separation of hydrocarbons (as urea
adducts), sulfamic acid production, flame proofing agents, viscosity
modifier for starch, casein-based paper coatings, reported helpful in
treatment of sickle-cell anemia, diuretic, and antiseptic.
COMMENTS:
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may cause eye irritation. When heated to decomposition this
compound emits toxic fumes.
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS: Not available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and protect it from moisture.
SPILLS AND LEAKAGE:
If you spill this chemical, you should dampen the solid spill material
with water,then transfer the dampened material to a suitable container. Use
absorbent paper dampened with water to pick up any remaining material. Seal
your contaminated clothing and the absorbent paper in a vapor-tight plastic
bag for eventual disposal. Wash all contaminated surfaces with a soap
and water solution. Do not reenter the contaminated area until the Safety
Officer (or other responsible person) has verified that the area has been
properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS: Symptoms of exposure to this compound include eye irritation.
FIREFIGHTING:
SOURCES
SOURCES:
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic
Effects of Chemical Substances. DHEW (NIOSH) Publication
No. 79-100. National Institute for Occupational Safety
and Health. Cincinnati, OH. 1979. YR6250000.
Windholz, M., Ed. The Merck Index. 9th Ed. Merck and Co.
Rahway, NJ. 1976. PP.1266 NO.9525.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 9th Ed.
Van Nostrand Reinhold. New York. 1977. PP.905.
Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry
and Physics. 60th Ed. CRC Press, Inc. Boca Raton, FL.
1982. PP.C-536 NO.U18.
Sax, N.I. Dangerous Properties of Industrial Materials. 4th Ed.
Van Nostrand Reinhold. New York. 1975. PP.467.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemicals. Aldrich Chemical Co., Inc. Milwaukee, WI.
1980. NO.U270-9
Proctor, N.H. and J.P. Hughes. Chemical Hazards of the Workplace.
J.B. Lippincott. Philadelphia. 1978. NOT LISTED.
International Technical Information Institute. Toxic and
Hazardous Industrial Chemicals Safety Manual for Handling
and Disposal with Toxicity and Hazard Data. International
Technical Information Institute. 1978. NOT LISTED.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. LISTED.
Steere, N.V., Ed. Handbook of Laboratory Safety. 2nd Ed.
CRC Press, Inc. Cleveland, OH. 1971. PP.826.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. LISTED.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. LISTED.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. NOT LISTED.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 8.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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