NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000770
CAS NUMBER: 52-68-6
BASE CHEMICAL NAME: TRICHLORFON
PRIMARY NAME: TRICHLORFON
CHEMICAL FORMULA: C4H8Cl3O4P
STRUCTURAL FORMULA: (CH3O)2P(O)CH(OH)CCl3
WLN: GXGGYQPO&O1&O1
SYNONYMS:
CHLOROPHOS
DIMETHOXY-2,2,2-TRICHLORO-1-HYDROXYETHYLPHOSPHINE OXIDE
O,O-DIMETHYL-(1-HYDROXY-2,2,2-TRICHLORO)ETHYL PHOSPHATE
DIMETHYL-1-HYDROXY-2,2,2-TRICHLOROETHYL PHOSPHONATE
DIMETHYL 1-HYDROXY-2,2,2-TRICHLOROETHYLPHOSPHONATE
O,O-DIMETHYL(1-HYDROXY-2,2,2-TRICHLOROETHYL)PHOSPHONATE
O,O-DIMETHYL-1-OXY-2,2,2-TRICHLOROETHYL PHOSPHONATE
DIMETHYLTRICHLOROHYDROXYETHYL PHOSPHONATE
(2,2,2-TRICHLORO-1-HYDROXYETHYL)PHOSPHONIC ACID, DIMETHYL ESTER
DIPTEREX
DYLOX
ENT 19,763
1-HYDROXY-2,2,2-TRICHLOROETHYLPHOSPHONIC ACID DIMETHYL ESTER
METHYL CHLOROPHOS
NCI-C54831
TRICHLOROPHON
TRICHLORPHON
TRINEX
AEROL 1 (PESTICIDE)
AEROL 1
AGROFOROTOX
ANTHON
BAY 15922
BAYER 15922
BAYER L 13/59
BILARCIL
BOVINOX
BRITTEN
BRITON
CEKUFON
CHLORFOS
CHLORAK
CHLOROFOS
CHLOROFTALM
CHLOROPHTHALM
CHLOROXYPHOS
CICLOSOM
CHLOROPHOSE
COMBOT
COMBOT EQUINE
DANEX
DEP
DEP (PESTICIDE)
DEPTHON
DETF
O,O-DIMETHYL-2,2,2-TRICHLORO-1-HYDROXYETHYL PHOSPHONATE
DIMETOX
DIPTERAX
DIPTEREX 50
DIPTEVUR
DITRIFON
DYLOX-METASYSTOX R
DYREX
DYVON
EQUINO-ACID
EQUINO-AID
FLIBOL E
FLIEGENTELLER
FOROTOX
FOSCHLOR
FOSCHLOR 25
FOSCHLOR R
FOSCHLOR R-50
HYPODERMACID
LEIVASOM
LOISOL
MASOTEN
MAZOTEN
METIFONATE
METRIFONATE
METRIPHONATE
NA 2783
NEGUVON
NEGUVON A
PHOSCHLOR
PHOSCHLOR R50
POLFOSCHLOR
PROXOL
RICIFON
RITSIFON
SATOX 20WSC
SOLDEP
SOTIPOX
2,2,2-TRICHLOROETHYL DIMETHYL PHOSPHATE
TRICHLOROFON
((2,2,2-TRICHLORO-1-HYDROXYETHYL) DIMETHYLPHOSPHONATE)
2,2,2-TRICHLORO-1-HYDROXYETHYL-PHOSPHONATE, DIMETHYL ESTER
TRICHLORPHENE
TRICHLORPHON FN
TUGON
TUGON FLY BAIT
TUGON STABLE SPRAY
VERMICIDE BAYER 2349
VOLFARTOL
VOTEXIT
WEC 50
WOTEXIT
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White to pale yellow crystalline powder
REPOSITORY: White powder with a few yellow granules
MOLECULAR WEIGHT: 257.44
SPECIFIC GRAVITY: 1.73 @ 20/4 C [031,062,169,395]
DENSITY: 1.73 g/mL @ 20 C [051,173,371]
MP (DEG C): 83-84 C [036,062,172,173]
BP (DEG C): 100 C @ 0.1 mm Hg [051,169]
SOLUBILITIES:
WATER : 10-50 mg/mL @ 21 C (RAD)
DMSO : >=100 mg/mL @ 21 C (RAD)
95% ETHANOL : >=100 mg/mL @ 21 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 21 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: 750 g/L @ 25 C [031,053,169]
Pentane: Very slightly soluble [031]
Hexane: 0.8 g/L @ 25 C [169]
Oils: Insoluble [062]
Petroleum ether: Sparingly soluble [025,027]
Common organic solvents (except aliphatic hydrocarbons): Readily soluble [169]
Ether: 170 g/L @ 25 C [031,053,169]
Benzene: 15.2 g/L @ 25 C [031,053,169]
Most chlorinated hydrocarbons: Soluble [172,173,395]
Carbon tetrachloride: Poorly soluble [172,173,395]
Petroleum oils: Insoluble [053,172,173,395]
Trichloroethylene: Soluble [295]
Methylnaphthalenes: Soluble [295]
Xylenes: Soluble [295]
Alcohols: Soluble [053,295]
VOLATILITY:
Vapor pressure: 0.0000078 mm Hg @ 20 C [031,055,173,395]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with alkalies [031,053,169]. It is
corrosive to black iron and mild steel [051,053]. It is corrosive to
metals [169]. It is subject to hydrolysis [053,169].
STABILITY:
This chemical decomposes at higher temperatures in water and at pH <5.5
[053,172,173,395]. It is sensitive to prolonged exposure to moisture [053,
430]. It is unstable in alkaline solutions [053,295].
OTHER PHYSICAL DATA:
Ethyl ether odor [051]
Refractive index: 1.3439 @ 20 C [031,169,395]
Freezing point: 84 C [051,371]
Setting point: Not less than 73.5 C [295]
TOXICITY
NIOSH REGISTRY NUMBER: TA0700000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 150 mg/kg
LC50 ihl rat 1300 mg/m3
TCLo ihl hmn 1710 ug/m3/90D-I
LD50 skn rbt 1500 mg/kg
LD50 skn rat 2000 mg/kg
LD50 orl mus 300 mg/kg
LD50 ipr mus 425 mg/kg
LD50 scu mus 267 mg/kg
LD50 ivn mus 290 mg/kg
LD50 ims rat 395 mg/kg
LDLo ims rbt 500 mg/kg
LD50 ipr gpg 300 mg/kg
LD50 ipr ham 1 gm/kg
LD50 ipr rat 160 mg/kg
LD50 ipr rbt 60 mg/kg
LD50 ivn dog 150 mg/kg
LD50 orl bwd 37 mg/kg
LD50 orl cat 97 mg/kg
LD50 orl ckn 75 mg/kg
LD50 orl dog 400 mg/kg
LD50 orl rbt 160 mg/kg
LDLo orl gpg 420 mg/kg
LD50 orl qal 73110 ug/kg
LD50 scu ckn 125 mg/kg
LD50 scu dog 269 mg/kg
LD50 scu rat 400 mg/kg
LD50 unr mam 630 mg/kg
LD50 unr cat 98 mg/kg
LD50 unr rat 550 mg/kg
LD50 unr mus 445 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion, inhalation, intraperitoneal, subcutaneous, intra-
venous and intramuscular routes. Moderately toxic by skin contact and
possibly other routes. An experimental carcinogen and teratogen.
Experimental reproductive effects. Human mutagenic data. An eye
irritant.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: ims-rat 183 mg/kg/6W-I
TDLo: orl-rat 186 mg/kg/6W-I
TDLo: skn-rat 1950 mg/kg/22W-I
Review: IARC Cancer Review: Animal Inadequate Evidence
IARC: Not classifiable as a human carcinogen (Group 3) [015,395,610]
Status: NTP Carcinogenesis Studies; selected, April 1989
NTP Carcinogenesis Studies; on test (prechronic studies), April 1989
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
bfa-mus/sat 200 mg/kg | cyt-ham:lng 81 mg/L
cyt-mus-orl 100 mg/kg | cyt-mus-orl 8500 ug/kg
cyt-mus-ipr 51500 ug/kg | cyt-ofs-mul 1 uL/L
dnd-mus-ipr 160 mg/kg | cyt-hmn:leu 40 mg/L
dnr-omi 10 mg/plate | dns-hmn:oth 4 mol/L
dns-hmn:fbr 100 mg/L | dlt-mus-ipr 405 mg/kg
mrc-smc 5000 ppm | hma-mus/sat 50 mg/kg
msc-mus:lym 80 mg/L | mmo-esc 8650 ug/plate
mmo-omi 4 mg/plate | mmo-sat 3400 nmol/plate
mmo-ssp 20 mmol/L | mma-esc 1 mg/plate
mma-sat 3400 nmol/plate | mma-smc 5000 ppm
mma-ssp 20 mmol/L | otr-mus:emb 3 mg/L
sce-ham:lng 20 mg/L | sce-ham:ovr 2 gm/L
TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-rat 80 mg/kg (13D preg)
TDLo: orl-rat 1450 mg/kg (6-15D preg)
TDLo: orl-rat 750 mg/kg (6-15D preg)
TDLo: orl-mus 1500 mg/kg (10-14D preg)
TDLo: orl-mus 1800 mg/kg (12-14D preg)
TDLo: ipr-mus 60 mg/kg (9D preg)
TDLo: orl-ham 2 gm/kg (7-11D preg)
TDLo: orl-ham 1500 mg/kg (7-11D preg)
TDLo: orl-ham 400 mg/kg (8D preg)
TDLo: orl-gpg 600 mg/kg (36-53D preg)
TDLo: orl-rat 78400 ug/kg (16-22D preg)
TDLo: orl-rat 80 mg/kg (9D preg)
TDLo: orl-rat 2200 ug/kg (1-22D preg)
TDLo: orl-rbt 700 mg/kg (2-15D preg)
TDLo: unr-mus 4200 mg/kg (1-21D preg)
TDLo: ipr-mus 206 mg/kg (2-5D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-rbt 120 mg/6D-I MLD
Review: Toxicology Review-6
Standards and Regulations: DOT-Hazard: ORM-A; Label: None
Status: EPA Genetox Program 1988, Positive: Body fluid assay; Host-mediated
assay
EPA Genetox Program 1988, Positive: Histidine reversion-Ames test;
S cerevisiae-homozygosis
EPA Genetox Program 1988, Weakly Positive: In vitro UDS-human
fibroblast
EPA Genetox Program 1988, Positive/dose response: TRP reversion
EPA Genetox Program 1988, Negative: D melanogaster Sex-linked lethal
EPA Genetox Program 1988, Inconclusive: Mammalian micronucleus;
B subtilis rec assay
EPA Genetox Program 1988, Inconclusive: E coli polA without S9
EPA TSCA Test Submission (TSCATS) Data Base, June 1989
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Organophosphorus pesticides, solid, toxic, n.o.s.
UN/ID NUMBER: UN2783
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 619, Y619 MAXIMUM QUANTITY: 100 kg, 10 kg
CARGO : PKG. INSTR.: 619 MAXIMUM QUANTITY: 200 kg
SPECIAL PROVISIONS: None
USES:
This compound is an insecticide used to control houseflies and roaches,
and in agricultural applications against insects and mites. It is an insecti-
cide for field crops, vegetables and seed crops. It is used in horticulture,
food storage, gardening, households and animal husbandry. It is used in
anthelmintic compositions. It has been used pharmaceutically to treat human
parasitic infections, such as Ascariasis, Trichuriasis and Schistosomiases.
In animals, it has been used against grubs, bots, screwworms and ectoparasites.
COMMENTS:
The activity of this compound is attributed to its metabolic conversion to
dichlorvos [172].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is a CHOLINESTERASE INHIBITOR [025,031,062,151]. It is
very toxic by inhalation, ingestion or skin contact [295]. It is easily
absorbed through the skin [052,062]. When heated to decomposition it emits
toxic fumes of carbon monoxide, carbon dioxide, phosphorus oxides, hydrogen
chloride and chlorine [043,051,053].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Nitrile Edmont 37-165 0.60 mm 240 min
Butyl rubber North B-174 0.70 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material under ambient temperatures and protect from
moisture. If possible, it would be prudent to store this compound under inert
atmosphere.
SPILLS AND LEAKAGE:
If you spill this chemical, you should dampen the solid spill material
with water, then transfer the dampened material to a suitable container. Use
absorbent paper dampened with water to pick up any remaining material. Seal
your contaminated clothing and the absorbent paper in a vapor-tight plastic
bag for eventual disposal. Wash all contaminated surfaces with a soap
and water solution. Do not reenter the contaminated area until the Safety
Officer (or other responsible person) has verified that the area has been
properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
administer a slurry of activated charcoal in water and simultaneously call
a hospital or poison control center. IMMEDIATELY transport the victim to a
hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
This compound is a CHOLINESTERASE INHIBITOR and is readily absorbed
through the skin to cause central nervous system disturbances [051]. Symptoms
of exposure may include colic, unconsciousness, mental disturbances, loss of
memory and problem-solving ability, delirium, depression, anxiety, psychomotor
stimulation, hallucinations, paranoid delusions, severe polyneuropathy, vomit-
ing, stomach pain, frequent liquid stools, burning in the extremities, general
weakness, general fatigue, tiredness of the leg muscles, paresthesia in the
feet, legs, hands and arms; discoloration of the hands and feet; cranial nerve
involvement (including limited movement of the eyes and dysarthria), horizontal
nystagmus, muscle changes, wheezing with excessive salivation, bronchial secre-
tion and respiratory difficulty [173]. Other symptoms may include headache,
tremors, nausea, diarrhea, cyanosis, depressed appetite, miosis, peritoneal
paralysis, salivation, lacrimation, sweating, dyspnea, substernal tightness,
slow pulse, muscular cramps, ataxia, pyrexia, pulmonary edema, areflexia, loss
of sphincter control, coma, heart block, shock, respiratory failure and eye
effects such as increased permeability of the blood vessels in the anterior
eye, reduced corneal sensitivity with glaucoma, abnormalities in intraocular
tension and decreased visual acuity [371]. It may also cause vertigo [295].
SOURCES
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