NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000166
CAS NUMBER: 509-14-8
BASE CHEMICAL NAME: TETRANITROMETHANE
PRIMARY NAME: TETRANITROMETHANE
CHEMICAL FORMULA: CN4O8
STRUCTURAL FORMULA: C(NO2)4
WLN: WNXNWNWNW
SYNONYMS:
NCI-C55947
TNM
RCRA WASTE NUMBER P112
UN1510
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: LITERATURE: Pale, yellow liquid
REPOSITORY: Clear, light yellow liquid
MOLECULAR WEIGHT: 196.05
SPECIFIC GRAVITY: 1.6229 @ 25/4 C
DENSITY: Not available
MP (DEG C): 14.2 C
BP (DEG C): 126 C @ 760 mm Hg
SOLUBILITIES:
WATER : <1 mg/mL @ 20 C (RAD)
DMSO : >=100 mg/mL @ 20 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 20 C (RAD)
TOLUENE : Reacts violently
OTHER SOLVENTS:
Alcoholic potassium hydroxide: Soluble (Decomposes)
Ether: Soluble
Alkali: Very soluble
VOLATILITY:
Vapor pressure: 8 mm Hg @ 20 C; 20 mm Hg @ 35.2 C; 40 mm Hg @ 48.4 C
Vapor density : 6.8
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of >112 C (>235 F). It is probably combus-
tible. Fires involving this compound may be controlled by using a Halon
extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This compound is an oxidizer. It also reacts with iron, copper, brass, zinc,
aluminum, toluene, cotton, sodium, pyridine, organic materials, strong reducing
agents, strong bases, hydrocarbons, finely powdered metals and aromatic nitro
compounds. This compound decomposes violently in the presence of impurities.
It will attack some forms of plastics, rubbers and coatings.
STABILITY:
This chemical is air and light stable but heat sensitive. It is also
sensitive to friction and shock. UV spectrophotometric stability screening
indicates that solutions of this chemical in 95% ethanol are stable for at
least 24 hours when kept at 5 C (RAD).
OTHER PHYSICAL DATA:
Acrid biting odor
Refractive index: 1.4375 @ 20 C; 1.4358 @ 25 C
Viscosity: 1.76 cp @ 20 C
Specific gravity: 1.638 @ 20/4 C
Saturation concentration: 90 g/m3 @ 20 C, 154 g/m3 @ 30 C
TOXICITY
NIOSH REGISTRY NUMBER: PB4025000
TOXICITY:
typ. dose mode specie amount unit other
LD50 orl rat 130 mg/kg
LC50 ihl rat 18 ppm/4H
LD50 ivn rat 12600 ug/kg
LD50 orl mus 375 mg/kg
LC50 ihl mus 54 ppm/4H
LD50 ivn mus 63100 ug/kg
LD50 ipr mus 53 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: HIGH via oral, inhalation, intravenous, intraperitoneal routes. This
material is irritating to the eyes and respiratory passages and does serious
damage to the liver. It occurs as an impurity in crude TNT and is thought to
be mainly responsible for the irritating properties of that material. It can
cause pulmonary edema, mild methemoglobinemia and fatty degeneration of the
liver and kidneys. A skin irritant.
CARCINOGENICITY:
Status: NTP Carcinogenesis Studies (Inhalation); Clear Evidence: Male and
Female Rat, Male and Female Mouse [620]
MUTATION DATA:
test lowest dose | test lowest dose
---------- ---------------- | ---------- ----------------
Not available |
TERATOGENICITY (Reproductive Effects Data): Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 1 ppm [610]
Final Limit: PEL-TWA 1 ppm [610]
ACGIH: TLV-TWA 1 ppm [610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Standards and Regulations: DOT-Hazard: Oxidizer; Label: Oxidizer
Status: Reported in EPA TSCA Inventory, 1983
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Tetranitromethane
UN/ID NUMBER: UN1510
HAZARD CLASS: 5.1 SUBSIDIARY RISK: 6.1 PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: Forbidden MAXIMUM QUANTITY: Forbidden
CARGO : PKG. INSTR.: Forbidden MAXIMUM QUANTITY: Forbidden
SPECIAL PROVISIONS:
USES:
Oxidizer in rocket propellants, explosive in mixture with toluene, to increase
cetane number of diesel fuels, reagent for detecting the presence of double
bonds in organic compounds, blasting explosives and in detonating compositions.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is heat, friction and shock sensitive and can decompose violently
when impurities are present. When heated to decomposition it emits toxic
fumes of CO, CO2 and NOx. It is a lacrimator and can be absorbed through the
skin. It may be irritating to the eyes, skin, mucous membranes and the upper
respiratory tract.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemical:
Recommendations based on permeation test results are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): No information available
RECOMMENDED RESPIRATOR:
When working with this chemical, wear a NIOSH-approved full face
positive pressure supplied-air respirator or a self-contained breathing
apparatus (SCBA). [651]
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this chemical in a freezer and keep it away
from oxidizing materials.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center.
Generally, the induction of vomiting is NOT recommended outside of a
physician's care due to the risk of aspirating the chemical into the victim's
lungs. However, if the victim is conscious and not convulsing and if medical
help is not readily available, consider the risk of inducing vomiting because
of the high toxicity of the chemical ingested. Ipecac syrup or salt water may
be used in such an emergency. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include irritation of the skin, eyes,
mucous membranes and upper respiratory tract; lacrimation, burns, jaundice,
cyanosis, pain on urination, anemia, chest pain, cough, dizziness, dyspnea,
drowsiness, corneal damage, heart damage, irritability, shortness of breath,
unconciousness, headache, weakness, extreme exhaustion and central nervous
system depression.
SOURCES
SOURCES:
Midwest Research Institute. MRI Report for Tetranitromethane.
Kansas City, MO. January 23, 1981; February 20, 1981.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
American Conference of Governmental Industrial Hygienists.
Documentation of the Threshold Limit Values. 5th Ed.
American Conference of Governmental Industrial Hygienists.
Cincinnati, OH. 1986. p. 567.
Sax, N. Irving, Ed. Dangerous Properties of Industrial Materials Report.
Bi-monthly Updates. Van Nostrand Reinhold Company, Inc. New York.
September/October 1985. Vol. 5, #5, pp. 87-91.
Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-640; #t226.
Clayton, G.D. and F.E. Clayton, Eds. Patty's Industrial Hygiene
and Toxicology. Vol. 2. Third Revised Edition. John Wiley
and Sons. New York. 1981. Vol. IIC, pp. 4155-4157.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1986. p. 1251; #T2,500-3.
Bretherick, L. Handbook of Reactive Chemical Hazards. 3rd Ed.
Butterworths. London. 1985. pp. 186-187.
Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985. p. 1688;#A.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 5, p. 5291; #T-01637.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. PB4025000.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. pp. 2549-2550.
Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 518.
Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. 1983. Listed.
U.S. Department of Health and Human Services and U.S. Department
of Labor. NIOSH/OSHA Occupational Health Guidelines for Chemical
Hazards. 3 Vols. DHHS (NIOSH) Publication No. 81-123. January,
1981. Vol. 3.
Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 65th Ed. CRC Press, Inc. Boca Raton,
FL. 1984. p. C-373; #9095.
Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 1321; #9057.
Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. 1, p. 842; #M00425.
Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. p. 1093.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 1010.
Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. p. 157.
American Conference of Governmental Industrial Hygienists.
Threshold Limit Values and Biological Exposure Indices
for 1985-1986. American Conference of Governmental
Industrial Hygienists. Cincinnati, OH. 1985. p. 31.
Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
2nd Ed. Noyes, Publications. Park Ridge, NJ. 1985. pp. 850-851.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xxxv.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
-------------------------------------------------------------