NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 002243
CAS NUMBER: 464-49-3
BASE CHEMICAL NAME: CAMPHOR,D-
PRIMARY NAME: D-CAMPHOR
CHEMICAL FORMULA: C10H16O
STRUCTURAL FORMULA: Not printable
WLN: Not available
SYNONYMS:
ALCANFOR
(1R)-1,7,7-TRIMETHYLBICYCLO(2.2.1)HEPTAN-2-ONE
(+)-2-BORNANONE
D-2-BORNANONE
D-2-CAMPHANONE
(+)-CAMPHOR
D-(+)-CAMPHOR
(1R,4R)-(+)-CAMPHOR
CAMPHOR USP
JAPANESE CAMPHOR
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless or white crystals
REPOSITORY: White crystalline solid
MOLECULAR WEIGHT: 152.24
SPECIFIC GRAVITY: 0.9920 @ 25/4 C [205]
DENSITY: Not available
MP (DEG C): 178.8 C [017,043,205]
BP (DEG C): 204 C [025,451]
SOLUBILITIES:
WATER : <1 mg/mL @ 15 C (RAD)
DMSO : >=100 mg/mL @ 15 C (RAD)
95% ETHANOL : >=100 mg/mL @ 15 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 15 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Soluble [017,062]
Benzene: Soluble [017,043]
Chloroform: Soluble [062]
Ether: Soluble [017,043,455]
Carbon disulfide: Soluble [062,295]
Solvent naphtha: Soluble [062]
Fixed oils: Soluble [062,295,455]
Volatile oils: Soluble [062,295,455]
Turpentine oil: 1 in 1.5 [295]
Olive oil: 1 in 4 [295]
Glycerol: Practically insoluble [295]
Light petroleum oil: Soluble [295]
VOLATILITY:
Vapor pressure: 1 mm Hg @ 41.5 C [038,055]; 5 mm Hg @ 68.6 C [038]
Vapor density : 5.24 [451]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 64 C (148 F) [269,275]. It is
combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. The autoignition temperature
of this compound is 466 C (871 F) [062,451].
UEL: 3.5% [451] LEL: 0.6% [451]
REACTIVITY:
This chemical is incompatible with strong oxidizing agents, strong
reducing agents and chlorinated solvents [269].
STABILITY:
This chemical volatilizes at ordinary temperatures [025,295,455]. It
may be sensitive to heat, air and sunlight [269]. Solutions of this chemical
in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under
normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Sublimes [017,025,043,062]
Vapor pressure: 20 mm Hg @ 97.5 C; 40 mm Hg @ 114.0 C; 100 mm Hg @ 138 C [038]
Vapor pressure: 400 mm Hg @ 182 C; 700 mm Hg @ 209.2 C [038]
Burns readily with a bright, smoky flame [455]
Very steam-volatile [025]
Optical rotation (c = 5 in ethanol): +54.9 degrees @ 20 C [025]
Refractive index: 1.5462 [043]
Penetrating aromatic odor [055]
Taste is pungent and aromatic and is followed by a sensation of cold [295]
TOXICITY
NIOSH REGISTRY NUMBER: EX1260000
TOXICITY:
typ. dose mode specie amount units other
LDLo ipr cat 400 mg/kg
LDLo ipr rat 3500 mg/kg
LD90 ivn mus 525 mg/kg
LD50 orl mus 1310 mg/kg
LDLo scu mus 2200 mg/kg
LDLo scu rat 1700 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by intraperitoneal route. Moderately toxic by ingestion,
subcutaneous and intravenous routes. A skin irritant.
CARCINOGENICITY: Not available
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
Not available |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 2 mg/m3 [610]
Final Limit: PEL-TWA 2 mg/m3 [610]
ACGIH: TLV-TWA 2 ppm; STEL 3 ppm [610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 0
Flammability (F): 2
Reactivity (R): 0
H0: Materials which on exposure under fire conditions would offer no
hazard beyond that of ordinary combustible material (see NFPA for
details).
F2: Materials which must be moderately heated before ignition will occur
(see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 500 mg/24H MOD
Status: EPA TSCA Chemical Inventory, 1986
Fatal dose for a one-year-old child: 1 g [301]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Camphor
UN/ID NUMBER: UN2717
HAZARD CLASS: 4.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Flammable solid
PACKAGING: PASSENGER: PKG. INSTR.: 419, Y419 MAXIMUM QUANTITY: 25 kg, 10 kg
CARGO : PKG. INSTR.: 420 MAXIMUM QUANTITY: 100 kg
SPECIAL PROVISIONS: None
USES:
This compound is used as an odorant and flavorant in households. It
is also used as a plasticizer for cellulose esters and ethers, as an insect
repellent, as a chemical intermediate, as a plasticizer for cellulose nitrate,
other explosives and lacquers; and as a respiratory aid and stimulant in
camphorated oil. It is used in perfumery, pharmaceutical and industrial pro-
ducts, incense manufacture, varnishes, explosives, embalming fluid, plastics
manufacture, medicine (internal and external), insecticides, moth and mildew
proofings, tooth powder, flavorings and pyrotechnics. It is used for its
counter-irritant and rubefacient properties.
COMMENTS:
This compound is a major component of pine oil. It is present in forest
runoff [055]. The OSHA and ACGIH exposure limits listed are for synthetic
camphor.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is harmful by ingestion, inhalation and skin absorption.
It is a severe irritant and high concentrations are extremely destructive to
tissues of the mucous membranes and upper respiratory tract, eyes and skin
[269]. When heated to decomposition it emits acrid and irritating fumes [043].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Neoprene Edmont 29-870 0.48 mm 240 min
Butyl rubber North B-161 0.45 mm 480 min
Nitrile Edmont 37-155 0.38 mm 240 min
Natural rubber Best 65 NFW 0.15 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
Splash proof safety goggles should be worn while handling this
chemical. Alternatively, a full face respirator, equipped as above,
may be used to provide simultaneous eye and respiratory protection.
OTHER: Not available
STORAGE PRECAUTIONS:
You should protect this chemical from exposure to light. Keep
the container tightly closed under an inert atmosphere, and store
under refrigerated temperatures.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes
of the mouth, throat, and esophagus and, in addition, have a high risk of
being aspirated into the victim's lungs during vomiting which increases the
medical problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim
IMMEDIATELY to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include irritation of the skin,
eyes and mucous membranes [346]. High concentrations may cause extreme
destruction of tissue of the mucous membranes and upper respiratory tract,
eyes and skin [269]. Other symptoms of exposure include nausea, vomiting
and epileptiform convulsions [295,346,455]. It may cause colic, disturbed
vision, delirium and death due to respiratory failure [455]. It may also
cause diarrhea, excitement and irrational behavior [346]. Exposure may lead
to headache, dizziness, feeling of warmth, muscle twitching, difficulty
breathing, anuria, central nervous system depression and coma [295]. Expo-
sure may also lead to convulsions, burning sensation, coughing, wheezing,
laryngitis, shortness of breath, vertigo and mental confusion [269]. Inges-
tion of this compound may cause burning in the mouth and throat, epigastric
pain, thirst, feeling of tension, rigidity, rapid pulse, slow respiration,
twitching of the facial muscles, muscular spasms and unconsciousness [301].
Flickering, darkening or veiling of the vision may occur, with noises in the
ears and weakness. Several cases of superficial keratitis with temporary
loss of corneal epithelium have been reported [099].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. EX1260000.
June 6, 1989.
[017] Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 67th Ed. CRC Press, Inc. Boca Raton,
FL. 1986. p. C-189, #4491.
[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 1, pp. 970-971, #C-00105.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. pp. 238-239, #1770.
[038] Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 530.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. II, p. 689, #CBB250.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 381, #C00047.
[051] Sax, N. Irving, Ed. Dangerous Properties of Industrial Materials
Report. Bi-monthly Updates. Van Nostrand Reinhold Company, Inc.
New York. November/December 1981. Vol. 1, No. 8, pp. 33-34.
[055] Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
p. 330.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 212.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
C. Thomas, Publisher. Springfield, IL. 1986. pp. 173-174.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-194, #c5.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 345, #D.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 296, #85,730-0.
[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
The Pharmaceutical Press. London. 1982. p. 351, #263-j.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. p. 457.
[415] American Conference of Governmental Industrial Hygienists.
Threshold Limit Values and Biological Exposure Indices
for 1988-1989. American Conference of Governmental
Industrial Hygienists. Cincinnati, OH. 1988. p. 13.
[421] American Conference of Governmental Industrial Hygienists.
Documentation of the Threshold Limit Values. 5th Ed.
American Conference of Governmental Industrial Hygienists.
Cincinnati, OH. 1986. p. 94.
[451] National Fire Protection Association. Fire Protection Guide on
Hazardous Materials. 9th Ed. National Fire Protection
Association. Quincy, MA. 1986. p. 325M-24.
[455] The Pharmaceutical Society of Great Britain. The Pharmaceutical Codex.
11th Edition. The Pharmaceutical Press. London. 1979. pp. 129-130.
[545] Office of the Federal Register National Archives and Records
Administration. Federal Register, Dept. of Labor, Part III.
U.S. Government Printing Office. Washington. January 19, 1989.
p. 2927.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, pp. 19, 66.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. October 3, 1990.
Not listed.
-------------------------------------------------------------