NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001579
CAS NUMBER: 301-12-2
BASE CHEMICAL NAME: METASYSTOX-R
PRIMARY NAME: METASYSTOX-R
CHEMICAL FORMULA: C6H15O4PS2
STRUCTURAL FORMULA:
WLN: OS2&2SPO&O1&O1
SYNONYMS:
BAY 21097
BAYER 21097
DEMETON-O-METHYL SULFOXIDE
DEMETON-S-METHYL SULFOXIDE
DEMETON-METHYL SULPHOXIDE
O,O-DIMETHYL S-(2-ETHTHIONYLETHYL)PHOSPHOROTHIOATE
DIMETHYL S-(2-ETHTHIONYLETHYL)THIOPHOSPHATE
O,O-DIMETHYL S-(2-(ETHYLSULFINYL)ETHYL)O,O-DIMETHYL ESTER
O,O-DIMETHYL S-(2-ETHYLSULFINYL)ETHYL THIOPHOSPHATE
O,O-DIMETHYL S-ETHYLSULPHINYLETHYL PHOSPHOROTHIOLATE
ENT 24,964
ETHANETHIOL, 2-(ETHYLSULFINYL)-, S-ESTER WITH O,O-DIMETHYL PHOSPHOROTHIOATE
S-(2-(ETHYLSULFINYL)ETHYL)O,O-DIMETHYL PHOSPHOROTHIOATE
ISOMETHYLSYSTOX SULFOXIDE
METAISOSYSTOX SULFOXIDE
METASYSTEMOX
METHYL DEMETON-O-SULFOXIDE
METILMERCAPTOFOSOKSID
OXYDEMETONMETHYL
PHOSPHOROTHIOIC ACID, O,O-DIMETHYL S-(2-(ETHYLSULFINYL)ETHYL)ESTER
R2170
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: LITERATURE: Clear, amber liquid
REPOSITORY: Clear amber liquid
MOLECULAR WEIGHT: 246.3
SPECIFIC GRAVITY: 1.289 @ 20/4 C
DENSITY: Not available
MP (DEG C): <-10 C
BP (DEG C): 106 C @ 0.01 mm Hg
SOLUBILITIES:
WATER : 10-50 mg/mL @ 16 C (RAD)
DMSO : >=100 mg/mL @ 16 C (RAD)
95% ETHANOL : >=100 mg/mL @ 16 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 16 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS: Petroleum ether: Insoluble
VOLATILITY : Vapor pressure: 3.8 E-5 millibar @ 20 C
Vapor density: Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of <21.7 C (<71 F) (RAD). It is flammable.
Fires involving this material can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY: This material may be hydrolyzed by alkali.
STABILITY: This compound is stable under normal laboratory conditions.
OTHER PHYSICAL DATA:
Refractive index: 1.5216 @ 20 C
N.B.: The flash point measurement used the lot/batch from our inventory
which is a 50% solution; the flammability is probably due to the solvent).
TOXICITY
NIOSH REGISTRY NUMBER: TG1420000
TOXICITY:
typ. dose mode specie amount unit other
LD50 orl rat 30 mg/kg
LD50 ihl rat 1500 mg/kg
LD50 skn rat 100 mg/kg
LD50 ipr rat 20 mg/kg
LD50 ivn rat 47 mg/kg
LD50 unk rat 65 mg/kg
LD50 orl mus 30 mg/kg
LD50 ipr mus 8 mg/kg
LD50 orl gpg 120 mg/kg
LD50 ipr gpg 30 mg/kg
LD50 orl pgn 15 mg/kg
LD50 orl ckn 80 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR = Mutation data. HIGH oral, skin, intraperitoneal, intravenous and
unknown route toxicity. MODERATE via inhalation.
CARCINOGENICITY: Not available
MUTAGENICITY:
Mutagenic Data: mmo-esc 30 mmol/L/4H
sln-dmg-orl 430 umol/L/2D
mrc-smc 30 mmol/L/5H
sce-ham:lng 40 mg/L
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Review: Toxicology Review
Status: Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Organophosphorus pesticides, liquid, flammable,
toxic, n.o.s.
UN/ID NUMBER: UN2784
HAZARD CLASS: 3 SUBSIDIARY RISK: 6.1 PACKING GROUP: II
LABELS REQUIRED: Flammable liquid and Poison
PACKAGING: PASSENGER: PKG. INSTR.: 305, Y305 MAXIMUM QUANTITY: 1 L, 1 L
CARGO : PKG. INSTR.: 307 MAXIMUM QUANTITY: 60 L
SPECIAL PROVISIONS: None
USES: Systemic and contact insecticide; acaricide.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may be absorbed readily through the skin. Acute exposure
is evidenced by rapid onset of blurred vision and constricted pupils.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemical:
Recommendations based on permeation test results are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): No information available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material in a refrigerator.
SPILLS AND LEAKAGE:
If you spill this chemical, use absorbent paper to pick up all liquid
spill material. Your contaminated clothing and absorbent paper should be
sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all
contaminated surfaces with alcohol followed by washing with a strong soap and
water solution. Do not reenter the contaminated area until the Safety Officer
(or other responsible person) has verified that the area has been properly
cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
CHOLINESTERASE INHIBITORS ARE EXTREMELY TOXIC AND FAST-ACTING POISONS.
IMMEDIATELY call a hospital of poison control center and transport the victim
to a hospital. Atropine is an antidote for cholinesterase inhibitors but
should only be administered by properly trained personnel. In the absence of
this option and if the victim is conscious and not convulsing, it may be worth
considering the risk of inducing vomiting, even though the induction of
vomiting is not usually recommended outside of a physician's care. Ipecac
syrup or salt water may be used to induce vomiting in such an emergency.
If the victim is convulsing or unconscious, do not give anything by mouth,
assure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
This compound is a cholinesterase inhibitor. Symptoms from exposure to
this compound include anorexia; nausea; vomiting; diarrhea; excessive
salivation; pupillary constriction; bronchoconstriction; muscle twitching;
convulsions; coma; respiratory failure; pulmonary edema; perspiration;
dyspnea; and cyanosis. The effects are cumulative.
SOURCES
SOURCES:
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. TG1420000.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. pp. 864-865.
Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. Sect. II, p. 295, #1074.
Wiswesser, W.J., Ed. Pesticide Index. Entomological Society
of America. College Park, MD. 1976. p. 171.
Hartley, Douglas B.Sc., Ph.D., M.I.Inf.Sc. and Hamish Kidd B.Sc., Eds.
The Agrochemicals Handbook. The Royal Society of Chemistry.
Nottingham, England. 1983. Listed.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
Hayes, W.J., Jr. Pesticides Studied in Man. Williams and
Wilkins. Baltimore. 1982. pp. 342-3.
Worthing, C.R., Ed. The Pesticide Manual, A World Compendium.
6th Ed. British Crop Protection Council. London, England.
1979. p. 398.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
U.S. Environmental Protection Agency, Office of Toxic
Substances. Toxic Substances Control Act Chemical
Substances Inventory, Cumulative Supplement II to the
Initial Inventory. U.S. Environmental Protection Agency.
Washington, DC. 1982. Not listed.
U.S. Environmental Protection Agency, Office of Toxic Substances.
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Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Not listed.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 368.
Windholz, M., Ed. The Merck Index. 9th Ed. Merck and Co.
Rahway, NJ. 1976. p. 790; 5923.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. p. 4467; #O-01021.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 63.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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