NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001149
CAS NUMBER: 148-24-3
BASE CHEMICAL NAME: HYDROXYQUINOLINE,8-
PRIMARY NAME: 8-HYDROXYQUINOLINE
CHEMICAL FORMULA: C9H7NO
STRUCTURAL FORMULA: Not printable
WLN: T66 BNJ JQ
SYNONYMS:
HYDROXYBENZOPYRIDINE
OXINE
OXYBENZOPYRIDINE
OXYQUINOLINE
8-OXYQUINOLINE
PHENOPYRIDINE
8-QUINOL
8-QUINOLINOL
QUINOPHENOL
BIOQUIN
FENNOSAN
8-OQ
OXIN
OXYCHINOLIN
TUMEX
NCI-C55298
USAF EK-794
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White or faint yellow crystalline powder
REPOSITORY: Off-white powder
MOLECULAR WEIGHT: 145.16
SPECIFIC GRAVITY: Not available
DENSITY: 1.034 g/mL @ 209 C [016,047]
MP (DEG C): 76 C [033,043,205,395]
BP (DEG C): 267 C [033,043,205,395]
SOLUBILITIES:
WATER : <1 mg/mL @ 16 C (RAD)
DMSO : >=100 mg/mL @ 16 C (RAD)
95% ETHANOL : 50-100 mg/mL @ 16 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 16 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Soluble [016,033,295,395]
Alkalies: Soluble [043,062]
Formic acid: Soluble [062]
Acetic acid: Soluble [062]
Hydrochloric acid: Soluble [062]
Sulfuric acid: Soluble [062]
Aqueous mineral acids: Soluble [033,295,395]
Ether: Almost insoluble [033,395]
Benzene: Soluble [016,033,062,395]
Alcohol: Soluble [016,033,043,295]
Fixed oils: Soluble [295]
Liquid paraffin: Soluble [295]
Glycerol: Soluble [295]
VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical readily forms stable metal chelates [395]. It is incom-
patible with strong oxidizers [269]. It is also incompatible with many metal
ions [295].
STABILITY:
This chemical darkens on exposure to light [055,062,269]. Solutions
of this chemical in water, DMSO, 95% ethanol or acetone should be stable for
24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Phenolic odor [062]
Lambda max (in cyclohexane): 318 nm, 243 nm [395]
Boiling point: 266.6 C @ 752 mm Hg (sublimes) [016,047]
TOXICITY
NIOSH REGISTRY NUMBER: VC4200000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 1200 mg/kg
LD50 orl mus 20 gm/kg
LD50 ipr mus 43 mg/kg
LD50 scu mus 83600 ug/kg
LD20 orl gpg 1205 mg/kg
LD50 unr mam 1000 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by intraperitoneal and subcutaneous routes. Moderately toxic
by ingestion and possibly other routes. An experimental carcinogen,
neoplastigen, tumorigen and teratogen. A central nervous system
stimulant. Human mutagenic data.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 29 gm/kg/48W-I
TDLo: ivg-rat 33 gm/kg/82W-I
TDLo: skn-mus 7200 mg/kg/50W-I
TDLo: scu-mus 900 mg/kg/21W-I
TDLo: imp-mus 50 mg/kg
TDLo: ivg-mus 5600 mg/kg/35W-I
TD : orl-rat 34 gm/kg/84W-I
TD : imp-mus 80 mg/kg
TD : imp-mus 100 mg/kg
TD : ivg-mus 17 gm/kg/2Y-I
Review: IARC Cancer Review: Animal Inadequate Evidence
IARC: Not classifiable as a human carcinogen (Group 3) [015,395,610]
Status: NTP Carcinogenesis Studies (Feed); No Evidence: Male and Female Rat,
Male and Female Mouse [620]
MUTATION DATA: See RTECS printout for most current data
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
dnd-esc 10 umol/L | mmo-bcs 10 mmol/L
dni-hmn:hla 25 umol/L | bfa-rat/sat 600 mg/kg
mma-sat 10 ug/plate | msc-mus:lym 400 ug/L
cyt-ham:ovr 7500 ug/L | sce-ham:ovr 2600 ug/L
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Review: Toxicology Review-3
Status: EPA Genetox Program 1988, Positive: Histidine reversion-Ames test
EPA Genetox Program 1988, Negative: Carcinogenicity-mouse/rat; N
crassa-aneuploidy
EPA TSCA Chemical Inventory, 1989
EPA TSCA Test Submission (TSCATS) Data Base, April 1990
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This compound is used as a chelating agent in the determination of trace
metal ions, as a disinfectant, in the precipitating and separating of metals,
in fungistats and bactericides for textiles and for farm buildings, and as a
antimicrobial drug used in human medicine for the treatment of minor burns and
hemorrhoids. It may also be used as a bacteriostatic additive in hairdressing
preparations to control dandruff, as an analytical colorimetric reagent, and in
dye manufacture. It was once used in clinical medicine as a topical anti-
septic.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by ingestion [062]. It may be harmful by
inhalation or skin absorption [269]. It is an irritant of the skin, eyes,
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-174 0.60 mm 240 min
Nitrile Pioneer A14 0.54 mm 240 min
PE/EVOH/PE Safety4 4H 0.07 mm 240 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should protect this material from exposure to light, and store
it in a refrigerator.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include irritation of the skin,
eyes, mucous membranes and respiratory tract [269]. It also causes irritation
of the gastrointestinal tract [301].
SOURCES
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