NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000357
CAS NUMBER: 142-04-1
BASE CHEMICAL NAME: ANILINEHYDROCHLORIDE
PRIMARY NAME: ANILINE HYDROCHLORIDE
CHEMICAL FORMULA: C6H7N.HCl
STRUCTURAL FORMULA: Not printable
WLN: ZR &GH
SYNONYMS:
BENZENAMINE, HYDROCHLORIDE
HYDROCHLORIDE BENZENAMIDE
ANILINE CHLORIDE
ANILINE HYDROCHLORIDE
ANILINE SALT
ANILINIUM CHLORIDE
NCI-C03736
PHENYLAMINE HYDROCHLORIDE
USAF EK-442
C.I. 76001
UN 1548
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White crystals
REPOSITORY: Black granular solid
MOLECULAR WEIGHT: 129.60
SPECIFIC GRAVITY: Not available
DENSITY: 1.2215 g/mL
MP (DEG C): 198 C
BP (DEG C): 245 C
SOLUBILITIES:
WATER : <1 mg/mL @ 18 C (RAD)
DMSO : <1 mg/mL @ 18 C (RAD)
95% ETHANOL : <1 mg/mL @ 18 C (RAD)
METHANOL : Not available
ACETONE : <1 mg/mL @ 18 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Insoluble
Ether: Insoluble
VOLATILITY:
Vapor pressure: Not available
Vapor density : 4.46
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 190 C (380 F). It is combustible.
Fires involving this material can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with oxidizing materials.
STABILITY:
This compound is sensitive to air and light (darkens).
OTHER PHYSICAL DATA: Not available
TOXICITY
NIOSH REGISTRY NUMBER: CY0875000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 1072 mg/kg
LDLo ipr rat 500 mg/kg
LD50 orl mus 841 mg/kg
LD50 ipr mus 300 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: HIGH human unknown. MUTATION Data. A skin and eye irritant. An
experimental carcinogen and neoplastigen. HIGH via oral, intravenous
and inhalation routes. LOW via dermal routes.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 130 gm/kg/2Y-C
TD : orl-rat 238 gm/kg/2Y-C
TD : orl-rat 137 gm/kg/60W-C
TD : orl-rat 2163 gm/kg/2Y-C
TD : orl-rat 4326 gm/kg/2Y-C
Status: NCI Carcinogenesis Bioassay (Feed): Positive: Male and Female Rat
[620]
NCI Carcinogenesis Bioassay (Feed): Negative: Male and Female Mouse
[620]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ---------------- | ------------ -----------------
otr-rat:emb 79500 ng/plate | sce-ham:fbr 10 umol/L
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 3
Flammability (F): 1
Reactivity (R): None
H3: Materials extremely hazardous to health but areas may be entered
with extreme care (see NFPA for details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 500 mg/24H MOD
eye-rbt 20 mg/24H SEV
Standards and Regulations: DOT-IMO: Poison B; Label: St. Andrews Cross
Status: Reported in EPA TSCA Inventory, 1983
EPA Genetic Toxicology Program, January 1984
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Aniline hydrochloride
UN/ID NUMBER: UN1548
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 619, Y619 MAXIMUM QUANTITY: 100 kg, 10 kg
CARGO : PKG. INSTR.: 619 MAXIMUM QUANTITY: 200 kg
SPECIAL PROVISIONS: None
USES:
Intermediates; dyeing and printing; Aniline black.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by ingestion, inhalation, and skin absorption.
It is a severe skin and eye irritant. When heated to decomposition or on
contact with acid or acid fumes, it emits toxic fumes.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Permeation Test Results For The Neat (Undiluted) Chemical:
The permeation test results for the neat (undiluted) chemical are given
below. The breakthrough times of this chemical are given for each glove type
tested. The table is a presentation of actual test results, not specific
recommendations or suggestions. Avoid glove types which exhibit breakthrough
times of less than the anticipated task time plus an adequate safety factor.
If this chemical makes direct contact with your glove, or if a tear, puncture
or hole develops, replace them at once.
Glove Type Model Number Thickness Breakthrough Time
No information available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should protect this chemical from exposure to light. Keep
the container tightly closed under an inert atmosphere, and store it
in a freezer. STORE AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then
dampen the solid spill material with toluene, then transfer the dampened
material to a suitable container. Use absorbent paper dampened with toluene
to pick up any remaining material. Your contaminated clothing and absorbent
paper should be sealed in a vapor-tight plastic bag for eventual disposal.
Solvent-wash all contaminated surfaces with toluene followed by washing with
a soap and water solution. Do not reenter the contaminated area until
the Safety Officer (or other responsible person) has verified that the area
has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include headache, lethargy, joint
pains, lowered blood pressure, cyanosis, jaundice, anemia, and fainting.
SOURCES
SOURCES:
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. CY0875000.
Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 65th Ed. CRC Press, Inc. Boca Raton,
FL. 1984. p. C-95; #925.
Bretherick, L., Ed. Hazards in the Chemical Laboratory. 3rd Ed.
The Royal Society of Chemistry. London. 1981. p. 183.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 282.
Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. p. 204.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 72.
Bretherick, L. Handbook of Reactive Chemical Hazards. 2nd Ed.
Butterworths. London. 1984. p. 588.
Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. 1983. Listed.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1984. p. 90; #13,331-0.
Steere, N.V., Ed. Handbook of Laboratory Safety. 2nd Ed.
CRC Press, Inc. Cleveland, OH. 1971. p. 726; #61.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 59.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. October 3, 1990.
Listed.
-------------------------------------------------------------