NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001204
CAS NUMBER: 1406-66-2
BASE CHEMICAL NAME: TOCOPHEROL,ALPHA-
PRIMARY NAME: ALPHA-TOCOPHEROL
CHEMICAL FORMULA: C29H50O2
STRUCTURAL FORMULA:
WLN: T66 BOT&J C3Y&3Y&3Y C HQ I J
SYNONYMS:
VITAMIN E
5,7,8-TRIMETHYLTOCOL
ANTISTERILITY VITAMIN
EPROLIN-S
EPSILAN
EPHYNAL
SYNTOPHEROL
E-VIMIN
EVIPHEROL
ETAVIT
PHYTOGERMINE
PROFECUNDIN
TOKOPHARM
VITEOLIN
ESORB
VASCUALS
COVIREL
EVION
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: Pale yellow, viscous liquid
MOLECULAR WEIGHT: 430.69
SPECIFIC GRAVITY: 0.950 @ 25/4
DENSITY:Not available
MP (DEG C): 2.5-3.5 C
BP (DEG C): 350 C decomposes
SOLUBILITIES:
WATER : Insoluble
DMSO : Not available
95% ETHANOL : Soluble
METHANOL : Not available
ACETONE : Soluble
TOLUENE : Not available
OTHER SOLVENTS:
ORGANIC SOLBENTS: Soluble
OILS: Soluble
FATS: Soluble
CHLOROFORM: Soluble
FAT SOLVENTS: Soluble
LIPID SOLVENTS: Soluble
ETHER : Soluble
VOLATILITY : Not available
FLAMMABILITY(FLASH POINT):
Flash point data for this compound are unavailable, but it is probably
combustible. Fires involving this compound should be controlled using a
Halon, carbon dioxide, or dry chemical extinguisher.
UEL: Not available LEL: Not available
REACTIVITY: Not available
STABILITY:
This chemical is stable to heat and alkalies in the presence of oxygen, and is
not affected by acids up to 100 C. It is slowly oxidized by atmospheric
oxygen and rapidly oxidized by ferric and silver salts. It gradually darkens
on exposure to light.
OTHER PHYSICAL DATA: Maximum UV absorption: 294 nm
TOXICITY
NIOSH REGISTRY NUMBER: Not available
TOXICITY:
Not available
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR = U Used as a chemical preservative, nutrient, and/or as a dietary
supplement food additive.
CARCINOGENICITY: Not available
MUTAGENICITY: Not available
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA: Not available
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not available
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES: Not available
COMMENTS:
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
Information on the acute hazards of this chemical is not availa
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS: Not available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should protect this chemical from exposure to light. Keep
the container tightly closed under an inert atmosphere, and store
under refrigerated temperatures.
SPILLS AND LEAKAGE:
If you should spill this chemical, use absorbent paper to pick
up all liquid spill material. Your contaminated clothing and absorb-
ent paper should be sealed in a vapor-tight plastic bag for eventual
disposal. Solvent wash all contaminated surfaces with acetone followed
by washing with a strong soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person)
has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS: Information on the symptoms associated with this compound is not ava
FIREFIGHTING: Not available
SOURCES
SOURCES:
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1982. NOT LISTED.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. NOT LISTED
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. NOT LISTED
Grasselli, J.G., Ed. CRC Atlas of Spectral Data and Physical
Constants for Organic Compounds. CRC Press, Inc. Cleveland,
OH. 1973. B-941
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. NOT LISTED
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 1029
International Technical Information Institute. Toxic and
Hazardous Industrial Chemicals Safety Manual for Handling
and Disposal with Toxicity and Hazard Data. International
Technical Information Institute. 1978. NOT LISTED
Sax, N.I. Dangerous Properties of Industrial Materials. 5th Ed.
Van Nostrand Reinhold. New York. 1979. p.1034
Windholz, M., Ed. The Merck Index. 9th Ed. Merck and Co.
Rahway, NJ. 1976. p. 1290, no. 9681
Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry
and Physics. 60th Ed. CRC Press, Inc. Boca Raton, FL.
1982. p. C-518, no. t269
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic
Effects of Chemical Substances. DHEW (NIOSH) Publication
No. 79-100. National Institute for Occupational Safety
and Health. Cincinnati, OH. 1979. NOT LISTED
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Not listed.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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