NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000589
CAS NUMBER: 140-11-4
BASE CHEMICAL NAME: BENZYLACETATE
PRIMARY NAME: BENZYL ACETATE
CHEMICAL FORMULA: C9H10O2
STRUCTURAL FORMULA: CH3COOCH2C6H5
WLN: 1VO1R
SYNONYMS:
ACETIC ACID, BENZYL ESTER
ACETIC ACID, PHENYLMETHYL ESTER
ALPHA-ACETOXYTOLUENE
BENZYL ETHANOATE
PHENYLMETHYL ACETATE
(ACETOXYMETHYL)BENZENE
NCI-C06508
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear colorless liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 150.18
SPECIFIC GRAVITY: 1.0550 @ 20/4 C [017,047,395]
DENSITY: 1.059-1.062 g/mL @ 15 C [062]
MP (DEG C): -51.5 C [038,043,205,430]
BP (DEG C): 215.5 C [017,205,395,430]
SOLUBILITIES:
WATER : <1 mg/mL @ 23 C (RAD)
DMSO : >=100 mg/mL @ 23 C (RAD)
95% ETHANOL : >=100 mg/mL @ 23 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 23 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Cyclohexane: >=100 mg/mL @ 21 C (RAD)
Ether: Soluble [017,062,395,430]
VOLATILITY:
Vapor pressure: 1 mm Hg @ 45 C [038,043,395,430]; 10 mm Hg @ 87.6 C [038]
Vapor density : 5.1 [043,395,430]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 102 C (216 F) [031,043,205,275]. It
is combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. A water spray may also be
used [269,451]. The autoignition temperature is 460 C (862 F) [043,053,062,
451].
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is incompatible with strong oxidizing agents [043,053,269].
It is also incompatible with acids, bases and reducing agents [269].
STABILITY:
This chemical may be sensitive to light [052]. Solutions of this chemical
in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under
normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Specific gravity: 1.0526 @ 24/22 C [052]; 1.050 @ 25/4 C [031,053]
Density: 1.0515 g/mL @ 25 C [205]
Refractive index: 1.5232 @ 20 C [017,031,047,205]; 1.4998 @ 25 C [031]
Boiling point: 134 C @ 102 mm Hg [025,031]; 93-94 C @ 10 mm Hg [017,047]
Vapor pressure: 5 mm Hg @ 73.4 C; 20 mm Hg @ 102.3 C; 40 mm Hg @ 119.6 C [038]
Vapor pressure: 60 mm Hg @ 129.8 C; 760 mm Hg @ 213.5 C [038]
Pear-like odor [031,395]
log P octanol: 1.96 [395]
Lambda max (in methanol): 268 nm, 264 nm, 262 nm, 258 nm, 252 nm, 248 nm
(shoulder), 243 nm (shoulder), 237 nm (shoulder) (epsilon = 10200, 16400,
15800, 20200, 15700, 11300, 7800, 5400) [052]
TOXICITY
NIOSH REGISTRY NUMBER: AF5075000
TOXICITY:
typ. dose mode specie amount units other
TCLo ihl hmn 50 ppm
LD50 orl rat 2490 mg/kg
LD50 orl mus 830 mg/kg
LCLo ihl mus 1300 mg/m3/22H
LC50 ihl cat 245 ppm/8H
LDLo skn cat 10 gm/kg
LD50 orl rbt 2200 mg/kg
LDLo scu rbt 3000 mg/kg
LD50 orl gpg 2200 mg/kg
LDLo scu gpg 3000 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: A poison by inhalation. Moderately toxic by ingestion and subcutaneous
routes. Human systemic effects by inhalation: an antipsychotic,
unspecified respiratory and urinary system effects.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-mus 258 gm/kg/2Y-I
TDLo: orl-rat 258 gm/kg/2Y-I
Review: IARC Cancer Review: Animal Limited Evidence
IARC: Not classifiable as a human carcinogen (Group 3) [610]
Status: NTP Carcinogenesis Studies (Gavage); Equivocal Evidence: Male Rat
[620]
NTP Carcinogenesis Studies (Gavage); No Evidence: Female Rat [620]
NTP Carcinogenesis Studies (Gavage); Some Evidence: Male and Female
Mouse [620]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mma-mus:lym 1313 mg/L | dnr-bcs 21 mg/disc
msc-mus:lym 700 mg/L |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 1
Flammability (F): 1
Reactivity (R): 0
H1: Materials only slightly hazardous to health (see NFPA for details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 100 mg/24H MOD
Status: EPA TSCA Chemical Inventory, 1986
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
This compound is used in perfumes, flavor ingredients, solvents for
cellulose acetate, cellulose nitrate and natural and synthetic resins; oils,
lacquers, polishes, printing inks, varnish removers, food processing and as a
food additive in nonalcoholic beverages, ice cream, ices, sweets, baked goods,
gelatins, puddings and chewing gum.
COMMENTS:
This compound occurs in jasmine [025,031,053,430].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS: Not available
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Unknown North Silvershield 0.10 mm 480 min.
Latex Ackwell 5-109 0.38 mm 15 min.
Nitrile Edmont 37-155 0.41 mm 60 min.
Permeation Test Results of Diluted Chemical in Water:
The permeation test results for solutions of this chemical are given
below. The breakthrough times of the diluted chemical at three different
concentrations are given for each glove type. The table is a presentation
of actual test results, not specific recommendations. Gloves which exhibit
breakthrough times of less than the anticipated task time plus adequate buffer
time, should be avoided. If a solution of this chemical makes direct contact
with your glove, or if a tear, puncture or hole develops, replace them at once.
Glove Type Model Number 50% (w/v) 25% (w/v) 1% (w/v)
Unknown North Silvershield 480 min. 480 min. 480 min.
Latex Ackwell 5-109 15 min. 15 min. 30 min.
Nitrile Edmont 37-155 15 min. 15 min. 15 min.
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should protect this material from exposure to light. Keep it away
from oxidizing materials and store it under refrigerated temperatures.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include irritation of the skin,
eyes and respiratory tract [031,052,053,430]. Ingestion may cause gastrointes-
tinal irritation with vomiting and diarrhea [031]. Other symptoms include a
decrease in blood pressure and depth of respiration and an increase in cardiac
rate [430]. Behavioral (antipsychotic) effects have been reported [015].
SOURCES
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