NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000598
CAS NUMBER: 137-30-4
BASE CHEMICAL NAME: ZIRAM
PRIMARY NAME: ZIRAM
CHEMICAL FORMULA: C6H12N2S4.Zn
STRUCTURAL FORMULA: Not printable
WLN: 1N1&YUS&S-ZN-SYUS&N1&1
SYNONYMS:
BIS(DIMETHYLDITHIOCARBAMATO)ZINC
ZINC, BIS(DIMETHLDITHIOCARBAMATO)-
BIS(DIMETHYLCARBAMODITHIOATO-S,S')ZINC
DIMETHYLDITHIOCARBAMIC ACID, ZINC SALT
ZINC BIS(DIMETHYLDITHIOCARBAMOYL)DISULPHIDE
ZINC DIMETHYLDITHIOCARBAMATE
FUNGOSTOP
HEXAZIR
KARBAM WHITE
DRUPINA 90
FUCLASIN ULTRA
ACCELERATOR L
METHASAN
METHAZATE
METHYL ZIMATE
ACETO ZDED
ACETO ZDMD
METHYL ZIRAM
MEXENE
MEZENE
MILBAM
MILBAN
MOLURAME
ORCHARD BRAND ZIRAM
POMARSOL Z FORTE
CARBAZINC
CORONA COROZATE
COROZATE
CUMAN
CYMATE
DIMETHYLCARBAMODITHIOIC ACID, ZINC COMPLEX
DIMETHYLCARBAMODITHIOIC ACID, ZINC SALT
DIMETHYLDITHIOCARBAMATE ZINC SALT
EPTAC 1
ENT 988
FUCLASIN
FUKLASIN
PRODARAM
RHODIACID
SOXINAL PZ
SOXINOL PZ
TRICARBAMIX Z
TRISCABOL
TSIMAT
USAF P-2
VANCIDE MZ-96
VULCACURE
VULCACURE ZM
VULKACITE L
VULKACIT L
Z 75
ZC
Z-C SPRAY
ZERLATE
ZIMATE
ZINC BIS(DIMETHYLTHIOCARBAMOYL)DISULFIDE
ZINC N,N-DIMETHYLDITHIOCARBAMATE
ZINCMATE
ZINKCARBAMATE
ZIRAME
ZIRAMVIS
ZIRASAN
ZIRBERK
ZIREX 90
ZIRIDE
ZITOX
NCI-C50442
AAVOLEX
AAZIRA
ANTENE
AMYL ZIMATE
CARBAMIC ACID, DIMETHYLDITHIO-, ZINC SALT (2:1)
CIRAM
CUMAN L
HERMAT ZDM
METHYL ZINEB
MYCRONIL
ZARLATE
ZIMATE, METHYL
ZIRASAN 90
ZIRTHANE
AAPROTECT
ZINC BIS(DIMETHYLDITHIOCARBAMATE)
ZIRAM TECHNICAL
ALCOBAM ZM
ZINC, (BIS(DIMETHYLCARBAMODITHIOATO-S,S)-T-4)-
METHYL CYMATE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White powder
REPOSITORY: White powder
MOLECULAR WEIGHT: 305.81
SPECIFIC GRAVITY: 1.66 @ 25/4 C [033,169]
DENSITY: 1.66 g/mL @ 23 C [173]
MP (DEG C): 250 C [033,173]
BP (DEG C): Not available
SOLUBILITIES:
WATER : <1 mg/mL @ 21 C (RAD)
DMSO : <1 mg/mL @ 21 C (RAD)
95% ETHANOL : <1 mg/mL @ 21 C (RAD)
METHANOL : <1 mg/mL @ 18 C (RAD)
ACETONE : <1 mg/mL @ 21 C (RAD)
TOLUENE : <1 mg/mL @ 18 C (RAD)
OTHER SOLVENTS:
5% Ammonium hydroxide: <1 mg/mL @ 22 C (RAD)
Benzene: <0.5 g/100 mL @ 25 C [033,395]
Ether: <0.2 g/100 mL @ 25 C [033]
Carbon tetrachloride: <0.2 g/100 mL @ 25 C [033]
Chloroform: Soluble [033,169,172,173]
Naphtha: 0.5 g/100 mL @ 25 C [033]
Dilute alkalies: Soluble [062,169,172,173]
Carbon disulfide: Soluble [062,169,172,173]
Concentrated hydrochloric acid: Soluble [062]
Non-polar solvents: Soluble [395]
Alcohol: <0.2 g/100 mL @ 25 C [033]
Organic solvents: Slightly soluble [058]
Dilute caustic solutions: Soluble [033]
VOLATILITY:
Vapor pressure: Negligible @ room temperature [169,172,173]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 93 C (200 F) [058]. It is combustible.
Fires involving this material can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher. A water spray may also be used [058]. This
compound may form explosive dust-air mixtures [033,058].
UEL: Not available LEL: Not available
REACTIVITY:
This chemical is corrosive to iron and copper [169]. It is incompatible
with strong oxidizing agents and acids [058]. It is also incompatible with
mercury [172,173].
STABILITY:
This chemical is stable under normal laboratory conditions [058].
UV spectrophotometric stability screening indicates that solutions of this
chemical in 95% ethanol are stable for at least 24 hours (RAD).
OTHER PHYSICAL DATA:
Melting point (dust): 148 C [395]
Odorless [173,346]
Low volatility @ 21.11 C (70 F) [058]
Specific gravity: 1.65 @ 20/20 C [043]
TOXICITY
NIOSH REGISTRY NUMBER: ZH0525000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 1400 mg/kg
LD50 unr rat 1230 mg/kg
LD50 ipr rat 23 mg/kg
LD50 orl mus 480 mg/kg
LD50 ipr mus 73 mg/kg
LD50 ivn mus 18 mg/kg
LD50 orl rbt 400 mg/kg
LDLo ipr rbt 50 mg/kg
LD50 orl gpg 200 mg/kg
LDLo ipr gpg 30 mg/kg
LD50 orl bwd 100 mg/kg
LD50 unr mam 1400 mg/kg
LD50 scu rbt 400 mg/kg
LD50 scu rat 1340 mg/kg
LD50 scu mus 800 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion, intraperitoneal and intravenous routes. Moderately
toxic by inhalation. Mutagenic data. An experimental carcinogen and
tumorigen.
CARCINOGENICITY:
Tumorigenic Data:
TD : orl-rat 13160 mg/kg/94W-I
TDLo: imp-rat 60 mg/kg
TDLo: orl-mus 840 mg/kg/13W-I
TDLo: orl-rat 12978 mg/kg/2Y-I
TD : orl-rat 25956 mg/kg/2Y-I
Review: IARC Cancer Review: Animal Inadequate Evidence
IARC: Not classifiable as a human carcinogen (Group 3) [015,395,610]
Status: NTP Carcinogenesis Bioassay (Feed); Positive: Male Rat [620]
NTP Carcinogenesis Bioassay (Feed); Negative: Female Rat and Male
Mouse [620]
NTP Carcinogenesis Bioassay (Feed); Equivocal: Female Mouse [620]
MUTATION DATA: See RTECS printout for most current data
test lowest dose | test lowest dose
----------- ---------------- | ----------- ----------------
mmo-sat 5 ug/plate | mma-sat 5 ug/plate
dnd-esc 1 umol/L | dnr-bcs 600 ng/disc
cyt-hmn:lym 10 nmol/L | sln-dmg-orl 500 mg/L
cyt-mus-orl 1750 mg/kg/5D-C | msc-mus:lym 62500 ng/L
cyt-ham:ovr 25 ug/L | mnt-mus-unr 350 mg/kg/24H
TERATOGENICITY: See RTECS printout for most current data
Reproductive Effects Data:
TDLo: orl-rat 500 mg/kg (6-15D preg)
TDLo: orl-rat 250 mg/kg (6-15D preg)
TDLo: orl-rat 1 gm/kg (6-15D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Status: EPA Genetox Program 1988, Negative: S cerevisiae gene conversion
EPA Genetox Program 1988, Inconclusive: B subtilis rec assay; D mela-
nogaster Sex-linked lethal
EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, January 1989
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
This compound is a rubber vulcanization accelerator. It is used in
adhesives including those used in food packaging, paper coats for non-food
contact, industrial cooling water, latex-coated articles, neoprene, paper and
paperboard, plastics (polyethylene and polystyrene) and textiles. It is also
used as an agricultural fungicide and as a repellant to birds and rodents.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is a skin and mucous membrane irritant [033,043,062]. It
may be absorbed through intact skin [151]. When heated to decomposition it
emits toxic fumes of carbon monoxide, carbon dioxide, sulfur oxides and nitro-
gen oxides [043,058].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
Permeation Test Results For The Neat (Undiluted) Chemical:
The permeation test results for the neat (undiluted) chemical are given
below. The breakthrough times of this chemical are given for each glove type
tested. The table is a presentation of actual test results, not specific
recommendations or suggestions. Avoid glove types which exhibit breakthrough
times of less than the anticipated task time plus an adequate safety factor.
If this chemical makes direct contact with your glove, or if a tear, puncture
or hole develops, replace them at once.
Glove Type Model Number Thickness Breakthrough Time
No information available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this chemical under ambient conditions, and keep it
away from all oxidizing materials.
SPILLS AND LEAKAGE:
If you spill this chemical, dampen the solid spill material with 5%
ammonium hydroxide, then transfer the dampened material to a suitable
container. Use absorbent paper dampened with 5% ammonium hydroxide to pick
up any remaining material. Your contaminated clothing and the absorbent
paper should be sealed in a vapor-tight plastic bag for eventual disposal.
Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing
with a soap and water solution. Do not reenter the contaminated area until the
Safety Officer (or other responsible person) has verified that the area has
been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include irritation of the skin,
nose, throat and eyes. It may also cause gastritis, reduced hemoglobin and
vegetodystonia [173]. Other symptoms include brain edema and hemorrhage.
In vivo, it may be corrosive to the eyes and cause hemolysis, dystrophy of the
muscle, liver and kidney damage, emphysema, local necrosis of the intestine,
neural and visual disturbances, irritation of the skin and mucous membranes
and dermatitis [151]. It can also cause headache, tightness of the chest and
irritation of the respiratory tract [058].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. ZH0525000.
August 15, 1989.
[033] Budavari, Susan, Ed. The Merck Index. 11th Ed. Merck and Co., Inc.
Rahway, NJ. 1989. p. 1602, #10075.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. II, p. 498, #BJK500.
[052] Midwest Research Institute. MRI Report for Ziram.
Kansas City, MO. December 2, 1976.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. August/September 1989.
#1033-070, A-05; #8709-008, C-13.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
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p. 1258.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
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[120] Oak Ridge National Laboratory. Environmental Teratogen Information
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[151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
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Baltimore. 1984. p. II-314, #1168.
[165] Wiswesser, W.J., Ed. Pesticide Index. Entomological Society
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[169] Hartley, Douglas B.Sc., Ph.D., M.I.Inf.Sc. and Hamish Kidd B.Sc., Eds.
The Agrochemicals Handbook. 2nd Ed. The Royal Society of Chemistry.
Nottingham, England. 1987. Listed.
[172] Worthing, C.R., Ed. The Pesticide Manual, A World Compendium.
8th Ed. British Crop Protection Council. London, England.
1987. pp. 850-851, #12420.
[173] Hayes, W.J., Jr. Pesticides Studied in Man. Williams and
Wilkins. Baltimore. 1982. pp. 606-607.
[186] Sittig, Marshall, Ed. Pesticide Manufacturing and Toxic Materials
Control Encyclopedia. Noyes Data Corporation. Park Ridge, NJ.
1980. pp. 771-773.
[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
The Pharmaceutical Press. London. 1982. pp. 830-831.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. p. 488.
[346] Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
2nd Ed. Noyes, Publications. Park Ridge, NJ. 1985. p. 943.
[395] International Agency for Research on Cancer, World Health
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Carcinogenic Risk of Chemicals to Man. International
Agency for Research on Cancer. Geneva. Vol. 12,
pp. 259-266; Supplement 7, p. 74.
[406] Goodman, L.S., A. Gilman, F. Murad and T.W. Rall, Eds. The
Pharmacological Basis of Therapeutics. 7th Ed. Macmillan
Publishing Co. New York. 1985. p. 1646.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
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[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
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