NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 002089
CAS NUMBER: 1333-82-0
BASE CHEMICAL NAME: CHROMIUMTRIOXIDE
PRIMARY NAME: CHROMIUM TRIOXIDE
CHEMICAL FORMULA: CrO3
STRUCTURAL FORMULA:
WLN: Not available
SYNONYMS:
Chromium oxide [CrO3]
CHROMIC ACID
CHROMIC ACID, SOLID
CHROMIC ACID, SOLUTION
CHROMIC ANHYDRIDE
CHROMIC TRIOXIDE
CHROMIC VI ACID
CHROMIUM OXIDE
CHROMIUM (6+) TRIOXIDE
5CHROMIUM TRIOXIDE, ANHYDROUS
CHROMIUM VI OXIDE
MONOCHROMIUM OXIDE
MONOCHROMIUM TRIOXIDE
PURATRONIC
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Dark, red crystals, flakes or powder
REPOSITORY: Not available
MOLECULAR WEIGHT: 100.00
SPECIFIC GRAVITY: Not available
DENSITY: 2.70 g/mL
MP (DEG C): 196 C
BP (DEG C): 250 C (decomposes)
SOLUBILITIES:
WATER : Very soluble
DMSO : Not available
95% ETHANOL : Soluble
METHANOL : Not available
ACETONE : Not available
TOLUENE : Not available
OTHER SOLVENTS: Sulfuric acid: Soluble
: Nitric acid: Soluble
VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Flash point data for this compound are not available. It is probably
combustible. Fires involving this material can be controlled with a
dry chemical, carabon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This compound is a powerful oxidizer and reacts with most organic substances
in a violent and possibly explosive manner. Pharmaceutical incompatibilities
include: alcohol, ether, glycerol, spirit nitrous ether; bromides; chlorides;
iodides; hypophosphites, sulfites and sulfides. Violent or explosive
reactions with acetic acid, acetic anhydride, phosphorous and selenium;
incandescence with potassium, sodium, ammonia, butyric acid, hydrogen sulfide;
may ignite acetone, methanol, ethanol, propan-2-ol, butanol, cyclohexanol,
N,N-dimethylformamide, pyridine and sulfur.
STABILITY:
This compound is sensitive to moisture.
OTHER PHYSICAL DATA: Not available
TOXICITY
NIOSH REGISTRY NUMBER: GB6650000
TOXICITY:
typ. dose mode specie amount units other
LD50 ipr mus 29 mg/kg
LDLo scu dog 330 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR = MUT data. An exper. TER, CAR. HIGH scu.
CARCINOGENICITY:
Tumorigenic Data:
TCLo: ihl-hmn 110 ug/m3/3Y-C
TDLo: imp-rat 125 mg/kg
Review: IARC Cancer Review: Human Inadequate Evidence
IARC Cancer Review: Animal Inadequate Evidence
IARC: Not classifiable as a human carcinogen [610]
Status: NTP human carcinogen [610]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mmo-sat 1 mmol/L | mma-sat 10 ug/plate
dnr-sat 50 mmol/L | dnd-esc 5 mmol/L
dnr-bcs 50 mmol/L | mrc-bcs 16 mmol/L
cyt-hmn:leu 2 mg/L | cyt-mus:mmr 1 umol/L/48H
cyt-ham:emb 3500 ug/L/24H | cyt-ham:ovr 250 ug/L
sce-ham:ovr 250 ug/L | sce-ham:fbr 320 ug/L
TERATOGENICITY:
Reproductive Effects Data:
TDLo: ivn-ham 5 mg/kg (8D preg)
TDLo: ivn-ham 7500 ug/kg (8D preg)
TDLo: ivn-ham 7500 ug/kg (8D preg)
TDLo: ivn-ham 8 mg/kg (8D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 1 mg(Cr(VI))/m3 [610]
Final Limit: PEL-TWA 1 mg(Cr(VI))/m3 [610]
ACGIH: TLV-TWA 0.5 mg(Cr(VI))/m3 [610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Review: Toxicology Review
Standards and Regulations: DOT-Hazard: Oxidizer; Label: Oxidizer, solid
DOT-Hazard: Corrosive Material; Label: Corrosive
Status: NTP Fourth Annual Report on Carcinogens, 1984
Reported in EPA TSCA Inventory, 1983
EPA Genetic Toxicology Program, January 1984
EPA TSCA Section 8(e) Status Report
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Chromium trioxide, anhydrous
UN/ID NUMBER: UN1463
HAZARD CLASS: 5.1 SUBSIDIARY RISK: 8 PACKING GROUP: II
LABELS REQUIRED: Oxidizer and Corrosive
PACKAGING: PASSENGER: PKG. INSTR.: 508, Y508 MAXIMUM QUANTITY: 5 kg, 2.5 kg
CARGO : PKG. INSTR.: 511 MAXIMUM QUANTITY: 25 kg
SPECIAL PROVISIONS: None
USES:
Used in chromium plating: copper stripping; aluminum anodizing; corrosion
inhibitor; photography; purifying oil and acetylene; hardening microscopical
preparations; oxidant in organic chemistry.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This material is a powerful oxidizer.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemical:
Recommendations based on permeation test results are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): No information available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should keep this material in a tightly closed container under an
inert atmosphere, and store it in an explosion-proof refrigerator. STORE
AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, you should dampen the solid spill material
with water,then transfer the dampened material to a suitable container. Use
absorbent paper dampened with water to pick up any remaining material. Seal
your contaminated clothing and the absorbent paper in a vapor-tight plastic
bag for eventual disposal. Wash all contaminated surfaces with a soap
and water solution. Do not reenter the contaminated area until the Safety
Officer (or other responsible person) has verified that the area has been
properly cleaned.
DISPOSAL AND WASTE TREATMENT:
Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
Some heavy metals are VERY TOXIC POISONS, especially if their salts are
very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and
arsenic). IMMEDIATELY call a hospital or poison control center and locate
activated charcoal, egg whites, or milk in case the medical advisor recommends
administering one of them. Also locate Ipecac syrup or a glass of salt water
in case the medical advisor recommends inducing vomiting. Usually, this is
NOT RECOMMENDED outside of a physician's care.
If advice from a physician is not readily available and the victim is
conscious and not convulsing, give the victim a glass of activated charcoal
slurry in water or, if this is not available, a glass of milk, or beaten egg
whites and IMMEDIATELY transport victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
assure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Dermal contact can cause primary irritation as well as ulceration and
allergic eczema. Inhalation can cause nasal irritation and septal
perforation. Pulmonary irritation, bronchogenic carcinoma may result
from inhalation of chromate dust. Ingestion causes violent gastroin-
testinal irritation with vomiting and diarrhea.
SOURCES
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of Chemical Substances. Microfiche Ed. National Institute for
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Chemistry and Physics. 65th Ed. CRC Press, Inc. Boca Raton,
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Arthur D. Little, Inc. Health and Safety Package for
Chromium Trioxide. Arthur D. Little, Inc.
Cambridge, MA.
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[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
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Not listed.
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