NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000040
CAS NUMBER: 1330-78-5
BASE CHEMICAL NAME: TRICRESYLPHOSPHATE
PRIMARY NAME: TRICRESYL PHOSPHATE
CHEMICAL FORMULA: C21H21O4P
STRUCTURAL FORMULA: (CH3C6H4O)3P(O)
WLN: 1R XOPO&OR X1&OR X1
SYNONYMS:
TRITOLYL PHOSPHATE
PHOSPHORIC ACID, TRITOLYL ESTER
CRESYL PHOSPHATE
TRIS(TOLYLOXY)PHOSPHINE OXIDE
PHOSPHORIC ACID, TRIS(METHYLPHENYL)ESTER
TRIS(METHYLPHENYL)ESTER OF PHOSPHORIC ACID
CELLUFLEX 179C
KRONITEX
LINDOL
TCP
DISFLAMOLL TKP
DURAD
FLEXOL PLASTICIZER TCP
FYRQUEL 150
IMOL S 140
NCI-C61041
PX-917
UN 2574
CELLUFLEX
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Pale brown, almost colorless, liquid
REPOSITORY: Clear, light yellow, viscous liquid
MOLECULAR WEIGHT: 368.37
SPECIFIC GRAVITY: 1.162 @ 25/25 C [055]
DENSITY: 1.247 g/mL @ 25 C [017,051]
MP (DEG C): -25 to -30 C [055]
BP (DEG C): 420 C [055]
SOLUBILITIES:
WATER : <1 mg/mL @ 18 C (RAD)
DMSO : >=100 mg/mL @ 18 C (RAD)
95% ETHANOL : >=100 mg/mL @ 18 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 18 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Common organic solvents and thinners: Miscible [033,058]
Linseed oil: Miscible [033]
Carbon tetrachloride: Very soluble [051]
Common vegatable oils: Miscible [058]
Ether: Soluble [017,051]
Alcohol: Soluble [017,051]
Benzene: Soluble [017,051]
Chloroform: Soluble [017]
China wood oil: Miscible [033]
Castor oil: Miscible [033]
VOLATILITY:
Vapor pressure: 0.1 mm Hg @ 155 C; 10 mm Hg @ 265 C [058]
Vapor density : 12.7 [055]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 240.6 C (465 F) [058]. It is
combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY:
This chemical may soften or deteriorate some plastics and elastomers
[058].
STABILITY:
This chemical will hydrolyze slowly under wet alkaline conditions at
ambient temperatures. It reacts with air only at elevated temperatures [058].
OTHER PHYSICAL DATA:
Specific gravity: 1.162 @ 20/20 C [058]
Boiling point: 244 C @ 3.5 mm Hg [017,051]; 265 C @ 10 mm Hg [033,275]
Specific heat: 0.38 [033]
Faint odor to odorless [058]
Refractive index: 1.55 @ 25 C [033]
Melting point also reported as 25-26 C [051]
Flash point also reported as 410 C (770 F) [033]
Pour point: -28 C [033]
Fire point: 363 C (685 F) [058]
Viscosity: 34 centipoise @ 37.8 [058]
TOXICITY
NIOSH REGISTRY NUMBER: TD0175000
TOXICITY:
typ. dose mode specie amount units other
TDLo orl wmn 70 mg/kg/14D
LD50 orl rat 5190 mg/kg
LDLo orl dog 500 mg/kg
LD50 skn cat 1500 mg/kg
LDLo orl rbt 100 mg/kg
LD50 orl mus 3900 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion. Moderately toxic by skin contact. Human systemic
effects by ingestion. Experimental reproductive effects. An eye and
skin irritant.
CARCINOGENICITY:
Status: NTP Carcinogenesis Studies; on test (two year studies), January 1990
MUTATION DATA: Not available
TERATOGENICITY: See RTECS printout for most current data
Reproductive Effects Data:
TDLo: orl-rat 90 gm/kg (90D male)
TDLo: orl-rat 27 gm/kg (90D pre)
TDLo: orl-mus 1750 mg/kg (7D male)
TDLo: orl-mus 4464 mg/kg (7D male/7D pre-22D preg)
TDLo: orl-mus 7250 mg/kg (7D pre/1-22D preg)
TDLo: orl-mus 2250 mg/kg (7D male/7D pre-22D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 500 mg open MLD
eye-rbt 500 mg/24H MLD
Standards and Regulations: DOT-IMO: Poison B; Label: Poison
Status: EPA TSCA Chemical Inventory, 1990
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
EPA TSCA Test Submission (TSCATS) Data Base, April 1990
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Tricresyl phosphate
UN/ID NUMBER: UN2574
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Poison
PACKAGING: PASSENGER: PKG. INSTR.: 610, Y610 MAXIMUM QUANTITY: 5 L, 1 L
CARGO : PKG. INSTR.: 612 MAXIMUM QUANTITY: 60 L
SPECIAL PROVISIONS: None
USES:
This compound is used as a plasticizer in vinyl plastics manufacturing,
as a flame-retardant, as a solvent for nitrocellulose and in cellulose molding
compositions. It is also used as an additive to extreme-pressure lubricants,
as a nonflammable fluid in hydraulic systems, as a lead scavenger in gasoline,
to sterilize certain surgical instruments, in polystyrene, in waterproofing,
in common organic solvents and thinners, in linseed oil, in china wood oil and
in castor oil.
COMMENTS:
This compound is a mixture of isomeric tritolyl phosphates, usually
excluding the very toxic ortho-isomer as much as possible [033]. The NTP
Master Agreement lot contains less than 0.1% of the tri-ortho isomer.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by inhalation, ingestion or by absorption through
the skin [036]. It is an irritant of the skin and eyes [043]. It is also an
irritant of the mucous membranes and respiratory tract [051]. When heated to
decomposition it emits toxic fumes of phosphorus oxides [043,058]. It is a
CHOLINESTERASE INHIBITOR in animals [058].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-174 0.70 mm 480 min
Natural rubber Ansell Conform 34205 0.18 mm 360 min
Neoprene Edmont 29-840 0.43 mm 360 min
PVC Edmont 34-100 0.19 mm 480 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under ambient temperatures,
and protect it from moisture. If possible, it would be prudent to
store this compound under inert atmosphere.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
administer a slurry of activated charcoal in water and simultaneously call
a hospital or poison control center. IMMEDIATELY transport the victim to a
hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include irritation of the skin and
eyes, flaccid paralysis without anesthesia, motor activity changes and muscle
weakness [043]. It may cause respiratory tract and mucous membrane irritation
[051]. It may also cause serious damage of the nervous and digestive systems
and muscular pain [036]. Other symptoms include gastrointestinal upset, dis-
comfort in distal portions of the arms and legs, soreness, aching, numbness,
headache, vertigo, loss of appetite, parethesias and decrease of strength in
the arms and legs [099]. It may cause vomiting, diarrhea and abdominal pain
[051,346]. It may also cause weakness of the distal muscles progressing to
foot drop, wrist drop, loss of plantar reflex and death from respiratory para-
lysis [301]. Exposure may also lead to tingling sensations of the hands and
feet and cramps. Cholinesterase inhibition has occured in animals [058].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. TD0175000.
June 21, 1990.
[017] Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 67th Ed. CRC Press, Inc. Boca Raton,
FL. 1986. p. C-220, #5378.
[033] Budavari, Susan, Ed. The Merck Index. 11th Ed. Merck and Co., Inc.
Rahway, NJ. 1989. p. 1535, #9675.
[036] Bretherick, L., Ed. Hazards in the Chemical Laboratory. 4th Ed.
The Royal Society of Chemistry. London. 1986. p. 545.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. III, p. 3429, #TNP500.
[051] Sax, N. Irving, Ed. Dangerous Properties of Industrial Materials
Report. Bi-monthly Updates. Van Nostrand Reinhold Company, Inc.
New York. May/June 1982. Vol. 2, #3, p. 83.
[052] Midwest Research Institute. MRI Report for Tricresyl phosphate.
Kansas City, MO. March 12, 1981.
[053] Arthur D. Little, Inc. Health and Safety Package for
Tricresyl phosphate. Arthur D. Little, Inc. Cambridge, MA.
March 26, 1981.
[055] Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
pp. 1148-1149.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. April/May 1989.
#1060-036, C-2.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
C. Thomas, Publisher. Springfield, IL. 1986. p. 942.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. p. II-302, #1115.
[195] Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds. CFTA Cosmetic
Ingredient Dictionary. 3rd Ed. The Cosmetic, Toiletry and
Fragrance Assn. Inc. Washington. 1982. p. 322.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 1520, #26,891-7.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. p. 197.
[346] Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
2nd Ed. Noyes, Publications. Park Ridge, NJ. 1985. pp. 889-890.
[401] Nutt, A. R. Toxic Hazards of Rubber Chemicals. Elsevier
Applied Science Publishers. New York. 1984. p. 70.
[430] Clayton, G.D. and F.E. Clayton, Eds. Patty's Industrial Hygiene
and Toxicology. Vol. 2. Third Revised Edition. John Wiley
and Sons. New York. 1981. Vol. IIA, pp. 2366, 2372-2373.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 90.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Listed.
-------------------------------------------------------------