NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000318
CAS NUMBER: 127-07-1
BASE CHEMICAL NAME: HYDROXYUREA
PRIMARY NAME: HYDROXYUREA
CHEMICAL FORMULA: CH4N2O2
STRUCTURAL FORMULA: HONHCONH2
WLN: ZYQUNQ &421
ZVMQ &422
SYNONYMS:
HYDROXYCARBAMIDE
HYDROXYCARBAMINE
N-(AMINOCARBONYL)HYDROXYLAMINE
N-CARBAMOYLHYDROXYLAMINE
HYDROXYLUREA
CARBAMOHYDROXIMIC ACID
CARBAMOHYDROXAMIC ACID
CARBAMOYL OXIME
CARBAMYL HYDROXAMATE
HU
HYDREA
LITALIR
N-HYDROXYUREA
HYDROXY UREA (D4)
HIDRIX
HYDREIA
LITALER
HYDURA
NCI-C04831
NSC 32065
SQ 1089
BIOSUPRESSIN
CARBAMOHYDROXYAMIC ACID
ONCO-CARBIDE
OXYUREA
SK 22591
HYDUREA
1-HYDROXYUREA
WR 83799
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White to off-white crystalline powder
REPOSITORY: White crystalline solid
MOLECULAR WEIGHT: 76.07
SPECIFIC GRAVITY: Not available
DENSITY: Not available
MP (DEG C): 144-146 C (decomposes) [275]
BP (DEG C): Decomposes [017,042]
SOLUBILITIES:
WATER : >=100 mg/mL @ 21 C (RAD)
DMSO : 50-100 mg/mL @ 21 C (RAD)
95% ETHANOL : <1 mg/mL @ 21 C (RAD)
METHANOL : Not available
ACETONE : <1 mg/mL @ 21 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Ether: Insoluble [025]
Alcohol: Slightly soluble [295]
Alcohol (hot): Soluble [031,042,205,295]
VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
Flash point data for this chemical are not available; however, it is
probably combustible. Fires involving this material can be controlled with
a dry chemical, carbon dioxide or Halon extinguisher.
UEL: Not available LEL: Not available
REACTIVITY: Not available
STABILITY:
This chemical is hygroscopic and decomposes in the presence of moisture
[295]. Solutions of this chemical in water, DMSO, 95% ethanol or acetone
should be stable for 24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Odorless or almost odorless [295]
Tasteless [295]
TOXICITY
NIOSH REGISTRY NUMBER: YT4900000
TOXICITY:
typ. dose mode specie amount units other
TDLo orl hmn 80 mg/kg/D
TDLo ivn hmn 86 mg/kg
LD50 ipr mus 5800 mg/kg
TDLo unr man 160 mg/kg
LD10 scu mus 2400 mg/kg
LD50 unr rat 4300 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: An experimental teratogen and equivocal tumorigenic agent. In humans,
it has blood effects and unspecified effects. LOW via intraperitoneal
route.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: ipr-rat 2500 mg/kg/7W-I
TDLo: ipr-mus 9750 mg/kg/26W-I
TDLo: scu-mus 500 mg/kg
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ------------ -----------------
dnd-esc 100 mmol/L | mmo-clr 5 mmol/L
dni-esc 100 mmol/L | dni-nml:emb 20 mmol/L
pic-esc 1 mmol/L | oms-nml:emb 20 mmol/L
oms-bcs 10 mmol/L | dni-hmn-orl 50 mg/kg/10H-C
mrc-omi 75 mmol/L | dni-hmn-unr 25 mg/kg
dnd-omi 250 mg/L | oms-hmn:oth 1 mmol/L
dni-omi 10 mmol/L | dni-hmn:oth 1 mmol/L
cyt-omi 10 mmol/L | dns-hmn:fbr 10 mmol/L
oms-omi 75 mmol/L | cyt-hmn:hla 1 mmol/L
dni-smc 75 mmol/L | cyt-hmn:leu 333 umol/L/48H
oms-mus:lym 20 mg/L | dni-hmn:oth 10 mmol/L
dni-hmn:bmr 1 mmol/L | dni-hmn:lym 360 umol/L
dni-hmn:hla 1 umol/L/4H | dni-hmn:fbr 1300 umol/L
oms-hmn:lym 12 nmol/L | dni-hmn:hla 60 mg/L
dni-mus-ivg 1 pph | dni-mus:lym 200 umol/L
dni-hmn:oth 50 mg/L | oms-hmn:oth 50 mg/L
oms-hmn:lym 80 mg/L | oms-hmn:hla 60 mg/L
dni-omi 500 mg/L | dni-omi 75 mmol/L
oms-hmn:oth 50 mg/L | dnd-rat-ipr 500 mg/kg
dns-rat-ipr 300 mg/kg/8H | dns-rat:lvr 10 mmol/L
dni-rat-ipr 3 ug/kg/2H-I | cyt-ham:ovr 300 umol/L
dni-rat:lvr 1 mmol/L | mnt-mus-ipr 400 mg/kg
otr-mus:emb 10 umol/L | dnd-mus/mmr 200 mg/kg
dnd-mus:emb 40 mg/L | dns-mus-ipr 6 gm/kg
dns-mus:leu 100 umol/L | dni-mus:kdy 1 mmol/L
dni-mus:mmr 5 mmol/L | dni-mus:leu 10 mmol/L
dni-mus:spr 1 mmol/L/1H-C | dni-mus:fbr 2 mmol/L
dni-mus-ipr 100 mg/kg | oms-mus/mmr 200 mg/kg
dni-mus:oth 1 mmol/L | cyt-mus-ipr 20 mg/kg
cyt-mus:emb 50 umol/L | spm-mus-ipr 125 mg/kg/5D
dni-ham:ovr 100 mg/L | dni-ham:fbr 10 ug/L
dni-ham:lng 200 umol/L | dni-ham:kdy 13 umol/L
dni-ham:emb 1 mmol/L | cyt-ham:lng 500 ug/L
cyt-ham:oth 50 umol/L | sce-ham:fbr 100 umol/L
dni-gpg:oth 5 mmol/L/30M-C | dni-gpg:kdy 1 mmol/L
dnd-mam:oth 100 umol/L | dnd-omi 50 mg/L
cyt-mus:lym 1 mmol/L | dni-hmn:oth 5 mmol/L
dni-rat-par 1500 mg/kg/3D-C | dns-hmn:oth 5 mmol/L
mrc-smc 7600 mg/L | mmo-smc 7600 mg/L
mma-ham:lng 20 mmol/L | mma-sat 1 mg/plate
sce-mus:lym 1 mmol/L | sln-smc 7600 mg/L
dni-hmn:oth 1 mmol/L | dnr-esc 250 ug/well
msc-mus:lym 10 mg/L | sce-ham:ovr 1 mmol/L
TERATOGENICITY:
Reproductive Effects Data:
TDLo: ipr-dog 150 mg/kg (21D preg)
TDLo: ipr-dog 450 mg/kg (20-22D preg)
TDLo: ipr-dog 450 mg/kg (21-23D preg)
TDLo: ipr-ham 50 mg/kg (5D male)
TDLo: ipr-mus 250 mg/kg (11D preg)
TDLo: ipr-mus 7 mg/kg (1D male)
TDLo: ipr-mus 800 mg/kg (11D preg)
TDLo: ipr-mus 300 mg/kg (9D preg)
TDLo: ipr-mus 500 mg/kg (10D preg)
TDLo: ipr-pig 450 mg/kg (14-16D preg)
TDLo: ipr-rat 1 gm/kg (12 preg)
TDLo: ipr-rat 250 mg/kg (9D preg)
TDLo: ipr-rat 200 mg/kg (9-12D preg)
TDLo: ivn-ham 50 mg/kg (8D preg)
TDLo: ivn-ham 400 mg/kg (8D preg)
TDLo: ivn-mus 500 mg/kg (10D preg)
TDLo: orl-cat 100 mg/kg (13-14D preg)
TDLo: orl-cat 1300 mg/kg (10-22D preg)
TDLo: orl-mus 2500 mg/kg (8-12D preg)
TDLo: orl-rat 2800 mg/kg (7-20D preg)
TDLo: orl-rat 3 gm/kg (6-15D preg)
TDLo: orl-rat 4500 mg/kg (6-15D preg)
TDLo: par-rat 150 mg/kg (9D preg)
TDLo: par-rat 1800 mg/kg (15D preg)
TDLo: scu-rat 650 mg/kg (12D preg)
TDLo: scu-rbt 650 mg/kg (12D preg)
TDLo: scu-rbt 750 mg/kg (12D preg)
TDLo: unr-mus 500 mg/kg (10D preg)
TDLo: unr-rat 500 mg/kg (12D preg)
TDLo: unr-rat 350 mg/kg (6D preg)
TDLo: unr-rat 2500 ug/kg (12D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-hmn 218 mg/3W
Review: Toxicology Review-3
Status: Meets criteria for proposed OSHA Medical Records Rule
EPA TSCA Test Submission (TSCATS) Data Base, March 1988
EPA Genetox Program 1986, Inconclusive: Carcinogenicity-mouse/rat;
Mammalian micronucleus
EPA Genetox Program 1986, Positive: Cell transform.-SA7/SHE
EPA Genetox Program 1986, Positive: In vitro cytogenetics-human
lymphocyte
EPA Genetox Program 1986, Positive: E coli polA without S9; sperm
morphology-mouse
EPA Genetox Program 1986, Positive: S cerevisiae gene conversion
EPA Genetox Program 1986, Negative: Cell transform.-BALB/c-3T3;
In vitro SCE-nonhuman
EPA Genetox Program 1986, Negative: V79 cell culture-gene mutation
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This compound is an antineoplastic agent and immunosuppressant. It
is used in the treatment of chronic myeloid leukemia, malignant melanomas
and inoperable tumors of the ovary, and squamous cell carcinomas of the
head and neck (with radiotherapy).
COMMENTS:
This compound is an inhibitor of DNA synthesis [275].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
When heated to decomposition this compound emits toxic fumes of NOx [042].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
Permeation Test Results For The Neat (Undiluted) Chemical:
The permeation test results for the neat (undiluted) chemical are given
below. The breakthrough times of this chemical are given for each glove type
tested. The table is a presentation of actual test results, not specific
recommendations or suggestions. Avoid glove types which exhibit breakthrough
times of less than the anticipated task time plus an adequate safety factor.
If this chemical makes direct contact with your glove, or if a tear, puncture
or hole develops, replace them at once.
Glove Type Model Number Thickness Breakthrough Time
No information available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and protect it from moisture.
SPILLS AND LEAKAGE:
If you spill this chemical, you should dampen the solid spill material
with water, then transfer the dampened material to a suitable container. Use
absorbent paper dampened with water to pick up any remaining material. Seal
your contaminated clothing and the absorbent paper in a vapor-tight plastic
bag for eventual disposal. Wash all contaminated surfaces with a soap
and water solution. Do not reenter the contaminated area until the Safety
Officer (or other responsible person) has verified that the area has been
properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include bone marrow suppression
including megaloblastic changes, pulmonary edema and neurological reactions
such as headache and dizziness [295]. Other neurological reactions include
drowsiness, disorientation, hallucinations and convulsions. Impairment of
renal function may occur [295,301]. Other symptoms include megaloblastic
anemia, leukopenia, thrombocytopenia, gastrointestinal disturbances, mild
dermatological reactions, stomatitis and alopecia [406]. Exposure may also
cause maculopapular rash, facial erythema, dysuria and fever [301].
Symptoms of exposure to this type of compound include anorexia, nausea,
vomiting, allergic reactions including skin rashes, erythema and pruritus,
hypotension, malaise, weakness, anaphylaxis, vesication or irritation of the
skin and mucous membranes and possible thrombophlebitis (when injected) [295].
Prolonged exposure to this type of compound may cause bone marrow depres-
sion, anemia, bleeding, immunosuppression, mouth ulcers, esophagitis, abdom-
inal pain, hemorrhage, diarrhea, intestinal ulceration and perforation, hyper-
uricemia, acute renal failure due to uric acid nephropathy, hyperphosphatemia,
pigmentaion of the skin and nails and jaundice [295].
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