NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001559
CAS NUMBER: 123-63-7
BASE CHEMICAL NAME: PARALDEHYDE
PRIMARY NAME: PARALDEHYDE
CHEMICAL FORMULA: C6H12O3
STRUCTURAL FORMULA:
WLN: Not available
SYNONYMS:
ACETALDEHYDE, TRIMER
ELALDEHYDE
PARAACETALDEHYDE
PARACETALDEHYDE
PARAL
PCHO
2,4,6-TRIMETHYL-S-TRIOXANE
2,4,6-TRIMETHYL-1,3,5-TRIOXANE
S-TRIMETHYLTRIOXYMETHYLENE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: Clear, colorless liquid
MOLECULAR WEIGHT: 132.16
SPECIFIC GRAVITY: 0.9943 @ 20/4 C
DENSITY:Not available
MP (DEG C): 12.6 C
BP (DEG C): 128 C
SOLUBILITIES:
WATER : Sparingly soluble
DMSO : Not available
95% ETHANOL : Very soluble
METHANOL : Not available
ACETONE : Not available
TOLUENE : Not available
OTHER SOLVENTS: Chloroform: Very soluble
ETHER : Very soluble
VOLATILITY : Not available
FLAMMABILITY(FLASH POINT):
The flash point for this compound is 35.5 C (96 F) and it is flammable.
Fires involving this compound can be controlled with dry chemical,
carbon dioxide or Halon extinguishers.
UEL: Not available LEL: Not available
REACTIVITY: Incompatible with alkalies, hydrocyanic acid iodides and oxidizers
STABILITY:
This compound is decomposed by light and air, on prolonged storage,
to acetaldehyde and acetic acid.
OTHER PHYSICAL DATA:
Refractive index: 1.4049 @ 20 C
Samples normally consist of a mixture of the two possible geometric
isomers, which can be separated by GLC.
Aromatic odor and a disagreeable, burning taste.
TOXICITY
NIOSH REGISTRY NUMBER: YK0525000
TOXICITY:
typ. dose mode specie amount unit other
LDlo unk man 1462 mg/kg
LD50 orl rat 1530 mg/kg
LClo ihl rat 2000 ppm/4H
LDlo ipr rat 2100 mg/kg
LDlo scu rat 1650 mg/kg
LDlo orl cat 3300 mg/kg
LD50 orl rbt 3304 mg/kg
LD50 skn rbt 14 gm/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR:Moderate via oral and Low via dermal routes. Psychotropic effects on
humans. An experimental neoplastigen via dermal route.
CARCINOGENICITY: Not available
MUTAGENICITY: Mutation data: cyt-smc 50 mmol/tube
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 2
Flammability (F): 3
Reactivity (R): 1
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F3: Materials which can be ignited under almost all normal temperature
conditions (see NFPA for details).
R1: Materials which are normally stable but which may become unstable at
elevated temperatures and pressures or which may react with water with
some release of energy but not violently (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 500 mg open MLD
eye-rbt 5 mg SEV
Review: Toxicology Review
Standards and Regulations: DOT-Flammable liquid; Label: Flammable liquid
Status: Reported in EPA TSCA Inventory, 1980
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Paraldehyde
UN/ID NUMBER: UN1264
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 309, Y309 MAXIMUM QUANTITY: 60 L, 10 L
CARGO : PKG. INSTR.: 310 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
Substitute for acetaldehyde; rubber accelerator and antioxidant;
synthetic organic chemicals; dyestuff intermediate; solvent for
fats, oils, gums, resins, leather; solvent mixtures for cellulose
derivatives; sedative (hypnotic).
COMMENTS: Abuse of this compound may lead to habituation.
DEA Schedule IV Controlled Substance
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is flammable. Vapors from this material are narc
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS: Not available
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should protect this chemical from exposure to light. Keep
the container tightly closed under an inert atmosphere, and store
under refrigerated temperatures.
SPILLS AND LEAKAGE:
If you spill this chemical, use absorbent paper to pick up all liquid
spill material. Your contaminated clothing and absorbent paper should be
sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all
contaminated surfaces with alcohol followed by washing with a strong soap and
water solution. Do not reenter the contaminated area until the Safety Officer
(or other responsible person) has verified that the area has been properly
cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Incoordination, drowsiness, sleep. With larger doses, pupils dilate,
loss of reflexes, coma. Weak pulse followed by cyanosis. Death
results from respiratory paralysis.
FIREFIGHTING: Not available
SOURCES
SOURCES: ?
Goodman, L.S. and A. Gilman. The Pharmacological Basis of
Therapeutics. 5th Ed. Macmillan Publishing Co. New
York. 1975. pp.131-132.
Sittig, M. Handbook of Toxic and Hazardous Chemicals. Noyes
Publications. Park Ridge, NJ. 1981. p.516.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Not listed.
Gosselin, R.E., H.C. Hodge, R.P. Smith and M.N. Gleason. Clinical
Toxicology of Commercial Products. 4th Ed. Williams and
Wilkins, Co. Baltimore. 1976. Sect.II, p.225, no.1186.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p.775.
Sax, N.I. Dangerous Properties of Industrial Materials. 5th Ed.
Van Nostrand Reinhold. New York. 1979. p.885.
Windholz, M., Ed. The Merck Index. 9th Ed. Merck and Co.
Rahway, NJ. 1976. p.911, no.6832.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol.4, p.4490, P-00133.
Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry
and Physics. 63rd Ed. CRC Press, Inc. Boca Raton, FL.
1982. p.C-413, no.10257.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. YK0525000.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xxxi.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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