NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001244
CAS NUMBER: 122-60-1
BASE CHEMICAL NAME: PHENYLGLYCIDYLETHER
PRIMARY NAME: PHENYL GLYCIDYL ETHER
CHEMICAL FORMULA: C9H10O2
STRUCTURAL FORMULA:
WLN: Not available
SYNONYMS:
PROPANE, 1,2-EPOXY-3-PHENOXY-
BENZENE, (2,3-EPOXYPROPOXY)-
1,2-EPOXY-3-PHENOXYPROPANE
2,3-EPOXYPROPYL PHENYL ETHER
ETHER, 2,3-EPOXYPROPYL PHENYL
ETHER, PHENYLGLYCIDYL
GLYCIDYL PHENYL ETHER
PGE
OXIRANE, (PHENOXYMETHYL)-
3-PHENOXY-1,2-EPOXYPROPANE
PHENOXYPROPENE OXIDE
PHENYL 2,3-EPOXYPROPYL ETHER
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: Literature: Colorless liquid
Repository: Colorless liquid
MOLECULAR WEIGHT: 150.19
SPECIFIC GRAVITY: 1.1092 @ 20/4 C
DENSITY: 4.37
MP (DEG C): 3.5 C
BP (DEG C): 245 C
SOLUBILITIES:
WATER : 1-5 mg/mL @ 18 C (RAD)
DMSO : >=100 mg/mL @ 18 C (RAD)
95% ETHANOL : >=100 mg/mL @ 18 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 18 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS: Not available
VOLATILITY: Vapor pressure: 0.01 mm Hg @ 20.0 C
Vapor density: 4.37
FLAMMABILITY(FLASH POINT):
The flash point for this chemical is >93.3 C (>200 F) (RAD); it is probably
combustible. Fires involving this compound can be controlled using a dry
chemical, carbon dioxide or Halon extinquisher.
UEL: Not available LEL: Not available
REACTIVITY: Not available
STABILITY: This chemical is stable under normal laboratory conditions.
OTHER PHYSICAL DATA: Not available
TOXICITY
NIOSH REGISTRY NUMBER: TZ3675000
TOXICITY:
typ. dose mode specie amount unit other
LD50 orl rat 3850 mg/kg
LD50 orl mus 1400 mg/kg
LD50 scu mus 760 mg/kg
LD50 skn rbt 1500 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION: THR: MUTATION data. A skin and eye irritant.
MODERATE via oral, subcutaneous and skin routes.
CARCINOGENICITY:
Tumorigenic Data:
TCLo: ihl-rat 12 ppm/6H/2Y-I
Review: IARC Cancer Review: Animal Sufficient Evidence
IARC possible human carcinogen (Group 2B) [610]
MUTAGENICITY:
mmo-sat 50 ug/plate mmo-klp 100 umol/L
mma-sat 500 ug/plate dnd-esc 1 umol/L
mmo-esc 20 umol/L otr-ham:emb 6250 ug/L
hma-mus/sat 2500 mg/kg
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 10 ppm [610]
Final Limit: PEL-TWA 1 ppm [610]
ACGIH: TLV-TWA 1 ppm [610]
NIOSH Criteria Document: Recommended Exposure Limit to this compound-air:
Ceiling Limit 5 mg/m3/15M [610]
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 10 mg/24H SEV
skn-rbt 500 mg/24H MOD
eye-rbt 111 mg MLD
eye-rbt 250 ug/24H SEV
Status: NIOSH Current Intelligence Bulletin 29, 1978
Reported in EPA TSCA Inventory, 1980
EPA TSCA 8(a) Preliminary Assessment Information Final Rule
EPA Genetic Toxicology Program, January 1984
EPA TSCA Section 8(e) Status Report 8EHQ-0179-0274
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
Organic synthesis; chemical intermediate with high solvency for halogenated
materials; component of epoxy resin systems.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound can cause skin, eye and mucous membrane irritation. When heated
to decomposition this compound emits acrid smoke and fumes.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS: Not available
RECOMMENDED RESPIRATOR:
When working with this chemical, wear a NIOSH-approved full face
positive pressure supplied-air respirator or a self-contained breathing
apparatus (SCBA). [651]
OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
STORAGE PRECAUTIONS:
You should store this material in a refrigerator. STORE AWAY
FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you should spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION,
then use absorbent paper to pick up all liquid spill material. Your contamina-
ted clothing and absorbent paper should be sealed in a vapor-tight plastic bag
for eventual disposal. Solvent wash all contaminated surfaces with acetone
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms following exposure to this compound may include irritation to the
eyes, skin, mucous membranes and upper respiratory tract, skin sensitization,
muscle fatigue, comatose, keratitis, liver damage, bronchitis, pneumonitis,
and hypotension.
FIREFIGHTING: Not available
SOURCES
SOURCES:
American Conference of Governmental Industrial Hygenists.
Documentation of the Threshold Limit Values. 4th ed.
American Conference of Governmental Industrial Hygenists.
Cincinnati, OH. 1980. p. 332.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. TZ3675000.
Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. pp. 990-991.
Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. 1983. Listed.
American Conference of Governmental Industrial Hygenists.
Threshold Limit Values for Chemical Substances and
Physical Agents in the Work Environment with Intended
Changes for 1982. American Conference of Governmental
Industrial Hygenists. Cincinnati, OH. 1982. p. 27.
Occupational Safety and Health Administration. Tentative
OSHA Listing of Confirmed and Suspected Carcinogens by
Category. Occupational Safety and Health Administration.
Washington, DC. 1979. Listed.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Steere, N.V., Ed. Handbook of Laboratory Safety. 2nd Ed.
CRC Press, Inc. Cleveland, OH. 1971. p. 764, #443.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substances Inventory,
Initial Inventory. 6 Vols. U.S. Environmental Protection
Agency. Washington, D.C. 1979. Listed.
Proctor, N.H. and J.P. Hughes. Chemical Hazards of the Workplace.
J.B. Lippincott. Philadelphia. 1978. pp. 412-3.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. p. 802.
International Technical Information Institute. Toxic and
Hazardous Industrial Chemicals Safety Manual for Handling
and Disposal with Toxicity and Hazard Data. International
Technical Information Institute. 1978. p. 409, #506.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 2189.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xxxi.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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