NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
ORTHO-BENZYL-PARA-CHLOROPHENOL
|
IDENTIFIERS
CATALOG ID NUMBER: 000866
CAS NUMBER: 120-32-1
BASE CHEMICAL NAME: BENZYLCHLOROPHENOL,ORTHO-,PARA-
PRIMARY NAME: ORTHO-BENZYL-PARA-CHLOROPHENOL
CHEMICAL FORMULA: C13H11ClO
STRUCTURAL FORMULA: C6H5CH2C6H3OHCl
WLN: QR DG B1R
SYNONYMS:
BENZYLCHLOROPHENOL
2-BENZYL-4-CHLOROPHENOL
O-BENZYL-P-CHLOROPHENOL
5-CHLORO-2-HYDROXYDIPHENYLMETHANE
CHLOROPHENE
4-CHLORO-ALPHA-PHENYL-ORTHO-CRESOL
CLOROFENE
CLOROPHENE
4-CHLORO-2-(PHENYLMETHYL)PHENOL
KETOLIN-H
ORTHOBENZYL-PARA-CHLOROPHENOL
ORTHOBENZYLPARACHLOROPHENOL
SANTOPHEN
SANTOPHEN 1
SANTOPHEN 1 FLAKE
SANTOPHEN 1 SOLUTION
SANTOPHEN 1 GERMICIDE
SEPTIPHENE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: White to light tan or pink flakes
REPOSITORY: White crystals
MOLECULAR WEIGHT: 218.68
SPECIFIC GRAVITY: 1.22 [058]
DENSITY: Not available
MP (DEG C): 48.5 C [025,031,047]
BP (DEG C): 160-162 C @ 3.5 mm Hg [025,031,047]
SOLUBILITIES:
WATER : <1 mg/mL @ 16 C (RAD)
DMSO : >=100 mg/mL @ 16 C (RAD)
95% ETHANOL : >=100 mg/mL @ 16 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 16 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Absolute ethanol: Soluble [052]
Alkaline solutions: Soluble [295]
Other organic solvents: Soluble [295]
VOLATILITY:
Vapor pressure: 0.1 mm Hg @ 20 C [058]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
The flash point for this chemical is 187.8 C (370 F) [058]. It is combustible.
Fires involving this compound should be controlled with a dry chemical, carbon
dioxide or Halon extinguisher. A water spray may also be used [058].
UEL: Not available LEL: Not available
REACTIVITY:
This compound is incompatible with acids and oxidizing agents [058].
STABILITY:
This compound is sensitive to light [052,295]. It is stable at temperatures
up to 25 C when protected from light, but storage at 60 C causes decomposition
[052]. Solutions of this chemical in water, DMSO, 95% ethanol or acetone
should be stable for 24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Boiling point: 327 C [058]
Specific gravity: 1.186-1.190 @ 55/15.5 C [031]
Crystallizing point: 45 C (minimum)
Slight phenolic odor
Dispersable in aqueous media with the aid of soaps or synthetic dispersing
agents
TOXICITY
NIOSH REGISTRY NUMBER: GO7175000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 1700 mg/kg
LD50 orl mus 65 mg/kg
LD50 scu mus 350 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: An experimental equivocal tumorigenic agent. MODERATE via oral route.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: skn-mus 14 gm/kg/34W-I
Status: NTP Carcinogenesis Studies; on test (two year studies), July 1987
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ------------ -----------------
Not available |
TERATOGENICITY (Reproductive Effects Data): Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Status: EPA TSCA Chemical Inventory, 1986
Meets criteria for proposed OSHA Medical Records Rule
Fatal dose: 5 g [301]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Other regulated substances
UN/ID NUMBER: ID8027
HAZARD CLASS: 9 SUBSIDIARY RISK: None PACKING GROUP: None
LABELS REQUIRED: Miscellaneous
PACKAGING: PASSENGER: PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
CARGO : PKG. INSTR.: 906 MAXIMUM QUANTITY: No limit
SPECIAL PROVISIONS: None
USES:
Disinfectant and germicide.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is a highly toxic irritant [062]. It is irritating to the skin
and respiratory tract, and corrosive to the eyes. It is also extremely cor-
rosive to the mouth and throat. When heated to decomposition it emits toxic
fumes of CO, CO2, chlorine or HCl, and other unidentified organic compounds
in black smoke [058].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Nitrile Edmont 37-155 0.38 mm 240 min.
Viton North F-091 0.24 mm 240 min.
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and protect it from light.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Phenols are very toxic poisons AND corrosive
and irritating, so that inducing vomiting may make medical problems worse.
IMMEDIATELY call a hospital or poison control center and locate activated
charcoal, egg whites, or milk in case the medical advisor recommends admini-
stering one of them.
If advice from a physician is not readily available and the victim is
conscious and not convulsing, give the victim a glass of activated charcoal
slurry in water or, if this is not available, a glass of milk, or beaten egg
whites and IMMEDIATELY transport victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
assure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound in humans include drowsiness, loss
of consciousness, irregular pulse and cyanosis. It may also cause irritation
of the skin and mucous membranes [052]. It is corrosive to the eyes, and
extremely corrosive to the mouth and throat. Swallowing dusts or solids
causes severe and rapid burning of the mouth, throat and digestive tract
accompanied by severe pain, vomiting and collapse [058]. It has also caused
severe porphyrea cutanea tarda [151].
Symptoms of exposure in laboratory animals include diarrhea, lassitude,
rapid breathing, dyspnea and death [151].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. GO7175000.
[025] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 1, p. 1190, #C-02068.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 343, #2367.
[042] Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 403.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. 1, p. 424, #C00801.
[052] Midwest Research Institute. MRI Report for o-Benzyl-p-chlorophenol.
Kansas City, MO. March 12, 1981.
[053] Arthur D. Little, Inc. Health and Safety Package for
o-Benzyl-p-chlorophenol. Arthur D. Little, Inc.
Cambridge, MA. December 21, 1983.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. Aug/Sept 1988.
#9106-063, C-03.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 136.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. p. II-193, #520.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-201, #c77.
[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
The Pharmaceutical Press. London. 1982. p. 559.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. p. 403.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 50.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. October 3, 1990.
Listed.
-------------------------------------------------------------