NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
TRIS(2-CHLOROETHYL) PHOSPHATE
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IDENTIFIERS
CATALOG ID NUMBER: 000561
CAS NUMBER: 115-96-8
BASE CHEMICAL NAME: CHLOROETHYLPHOSPHATE,TRIS,2-
PRIMARY NAME: TRIS(2-CHLOROETHYL) PHOSPHATE
CHEMICAL FORMULA: C6H12Cl3O4P
STRUCTURAL FORMULA: (ClCH2CH2O)3PO
WLN: G2OPO&O2GO2G
SYNONYMS:
ETHANOL, 2-CHLORO-, PHOSPHATE (3:1)
CELLUFLEX
TRI-BETA-CHLOROETHYL PHOSPHATE
TRICHLOROETHYL PHOSPHATE
TRI(2-CHLOROETHYL) PHOSPHATE
TRIS(BETA-CHLOROETHYL) PHOSPHATE
CELLUFLEX CEF
2-CHLOROETHANOL PHOSPHATE
PHOSPHORIC ACID, TRIS(2-CHLOROETHYL)ESTER
FYROL CEF
NIAX FLAME RETARDANT 3CF
NCI-C60128
TRIS(CHLOROETHYL) PHOSPHATE
TRIS(2-CHLOROETHYL) ORTHOPHOSPHATE
3CF
NIAX 3CF
DISFLAMOLL TCA
GENOMOLL P
TCEP
FYROL CF
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear liquid
REPOSITORY: Clear liquid
MOLECULAR WEIGHT: 285.49
SPECIFIC GRAVITY: 1.425 @ 20/20 C [043,062]
DENSITY: 1.390 g/mL [047,205,269,275]
MP (DEG C): <-60 C [058]
BP (DEG C): 330 C [047,205,269,275]
SOLUBILITIES:
WATER : 1-5 mg/mL @ 20 C (RAD)
DMSO : >=100 mg/mL @ 20 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 20 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Ether: Soluble [430]
VOLATILITY:
Vapor pressure: 0.5 mm Hg @ 145 C [043,430]
Vapor density : Not available
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 232 C (450 F) [205,269,275]. It is
combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. A water spray may also be
used [058]. The autoignition temperature is 601.7 C (1115 F) [043].
UEL: Not available LEL: Not available
REACTIVITY:
This compound is incompatible with strong oxidizing agents and strong
bases [269].
STABILITY:
This chemical is stable under normal laboratory conditions. Solutions
of this chemical in water, DMSO, 95% ethanol or acetone should be stable for
24 hours under normal lab conditions (RAD).
OTHER PHYSICAL DATA:
Refractive index: 1.4721 @ 20 C [047,062,205,269]
Boiling point: 214 C @ 25 mm Hg [062]; 210-220 C @ 20 mm Hg [043]
Decomposition begins at 170 C [058]
Density: 1.42 g/cm3 @ 20 C [058]
Odorless [058]
pH: Neutral [058]
TOXICITY
NIOSH REGISTRY NUMBER: KK2450000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 1230 mg/kg
LDLo ipr mus 250 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by intraperitoneal route. Moderately toxic by ingestion.
Experimental reproductive effects. A skin and eye irritant.
CARCINOGENICITY:
Status: NTP Carcinogenesis Studies; on test (two year studies), April 1989
MUTATION DATA:
test lowest dose | test lowest dose
----------- ------------------ | ----------- -----------------
sce-ham:lng 700 mg/L | mma-sat 1 umol/plate
mnt-ham-ipr 125 mg/kg | otr-ham:emb 400 mg/L
TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-rat 1800 mg/kg (7-15D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 10 mg/24H open MLD
skn-rbt 500 mg/24H MLD
eye-rbt 500 mg open
eye-rbt 500 mg/24H MLD
Review: Toxicology Review
Status: EPA TSCA Chemical Inventory, 1986
EPA Genetox Program 1988, Negative: Histidine reversion-Ames test
EPA TSCA Test Submission (TSCATS) Data Base, June 1989
Meets Criteria For Proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Not restricted
UN/ID NUMBER:
HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
LABELS REQUIRED:
PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
SPECIAL PROVISIONS:
USES:
This compound is used as a flame retardant and plasticizer.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
When heated to decomposition this compound emits toxic fumes of carbon
monoxide, carbon dioxide and hydrogen chloride gas [058,269]. It may also emit
very toxic fumes of phosphorus oxides and/or phosphine. The vapor or mist is
irritating to the eyes, mucous membranes and upper respiratory tract. It may
be harmful by inhalation, ingestion or skin absorption [269]. This compound
may be a weak CHOLINESTERASE INHIBITOR over time [430].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Neoprene Edmont 29-840 0.31 mm 360 min
Nitrile Edmont 37-165 0.60 mm 360 min
PVA Edmont 25-545 0.33 mm 360 min
PVC Edmont PVC Unknown 360 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this material in a refrigerator, and keep away from
oxidizing agents.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include discomfort, itching,
reddening, swelling and dermatitis [058]. It may also cause skin, eye, mucous
membrane and upper respiratory tract irritation [269]. This compound may be a
weak cholinesterase inhibitor over time [430].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. KK2450000.
September 20, 1989.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. II, pp. 813-814, #CG0500.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 421, #C00746.
[052] Midwest Research Institute. MRI Report for Tris (2-Chloroethyl)
Phosphate. Kansas City, MO. October 10, 1989.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. October/November 1989.
#5833-524, C-11.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 1194.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-682, #t772.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 1813, #D.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 1514, #11,966-O.
[430] Clayton, G.D. and F.E. Clayton, Eds. Patty's Industrial Hygiene
and Toxicology. Vol. 2. Third Revised Edition. John Wiley
and Sons. New York. 1981. Vol. IIA, pp. 2362-2363, 2383.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 49.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. October 3, 1990.
Listed.
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