NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000222
CAS NUMBER: 110-80-5
BASE CHEMICAL NAME: ETHOXYETHANOL,2-
PRIMARY NAME: 2-ETHOXYETHANOL
CHEMICAL FORMULA: C4H10O2
STRUCTURAL FORMULA: Not printable
WLN: Q202
SYNONYMS:
ETHYLENE GLYCOL ETHYL ETHER
CELLOSOLVE
ETHYL CELLOSOLVE
ETHYLENE GLYCOL MONOETHYL ETHER
GLYCOL MONOETHYL ETHER
ETHANOL, 2-ETHOXY-
CELLOSOLVE SOLVENT
DOWANOL EE
GLYCOL ETHYL ETHER
GLYCOL ETHER EE
HYDROXY ETHER
NCI-C54853
OXITOL
POLY-SOLV EE
UN 1171
RCRA WASTE NUMBER U227
RCRA WASTE NUMBER U359
EKTASOLVE EE
JEFFERSOL EE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear colorless liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 90.14
SPECIFIC GRAVITY: 0.9297 @ 20/4 C
DENSITY: 0.925 g/cm3 @ 23.9 C (RAD)
MP (DEG C): -70 C
BP (DEG C): 135 C
SOLUBILITIES:
WATER : >=100 mg/mL @ 18 C (RAD)
DMSO : >=100 mg/mL @ 18 C (RAD)
95% ETHANOL : >=100 mg/mL @ 18 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 18 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Liquid esters: Miscible
Ether: Miscible
VOLATILITY:
Vapor pressure: 3.8 mm Hg @ 20 C
Vapor density : 3.10
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 40.6 C (105 F); it is combustible.
Fires involving this material can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher. The autoignition temperature is 237 C (460 F).
UEL: 14% LEL: 1.8%
REACTIVITY:
This compound may react with oxidizing materials. It dissolves many oils,
resins and waxes.
STABILITY:
This chemical is stable under normal laboratory conditions.
OTHER PHYSICAL DATA:
Boiling point: 35 C @ 10 mm Hg
Refractive index: 1.4080 @ 20 C
TOXICITY
NIOSH REGISTRY NUMBER: KK8050000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 2125 mg/kg
LC50 ihl rat 2000 ppm/7H
LD50 orl mus 2451 mg/kg
LD50 ipr rat 2800 mg/kg
LD50 ivn rat 2400 mg/kg
LC50 ihl mus 1820 ppm/7H
LD50 ipr mus 1707 mg/kg
LDLo scu mus 5 gm/kg
LD50 ivn mus 3900 mg/kg
LD50 orl rbt 1275 mg/kg
LD50 skn rbt 3300 mg/kg
LD50 orl gpg 1400 mg/kg
LD50 unr rat 7750 mg/kg
LD50 unr mus 5799 mg/kg
LCLo ihl gpg 3000 ppm/24H
LD50 unr gpg 3070 mg/kg
LD50 skn rat 3900 mg/kg
LD50 scu rat 3400 mg/kg
LD50 scu rbt 2 gm/kg
LD50 ivn rbt 900 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: MODERATE via dermal and oral routes.
CARCINOGENICITY:
Status: NTP Carcinogenesis Studies; on test (prechronic studies), April 1990
MUTATION DATA: See RTECS printout for most current data
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
spm-rat-orl 23400 mg/kg/5W-I | cyt-ham:ovr 6830 mg/L
sce-ham:ovr 3170 mg/L |
TERATOGENICITY:
Reproductive Effects data:
TDLo: orl-rat 7820 mg/kg (1-21D preg)
TDLo: orl-rat 1955 mg/kg (1-21D preg)
TCLo: ihl-rat 767 ppm/7H (1-19D preg)
TDLo: scu-rat 1955 mg/kg (1-21D preg)
TCLo: ihl-rbt 160 ppm/7H (1-18D preg)
TCLo: ihl-rbt 617 ppm/7H (1-18D preg)
TDLo: orl-mus 25 gm/kg (25D male)
TCLo: ihl-rat 200 ppm/7H (1-19D preg)
TCLo: ihl-rat 600 ppm/7H (7-13D preg)
TCLo: ihl-rat 100 ppm/7H (14-20D preg)
TDLo: skn-rat 50 gm/kg (7-16D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 200 ppm (skin) [015,327,545,610]
Final Limit: PEL-TWA 200 ppm (skin) [015,545,610]
ACGIH: TLV-TWA 5 ppm (skin) [015,415,421,610]
NIOSH Criteria Document: Recommended Exposure Limit to glycol ethers-air:
Reduce exposure to lowest feasible level [610]
NFPA Hazard Rating: Health (H): 2
Flammability (F): 2
Reactivity (R): 0
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F2: Materials which must be moderately heated before ignition will occur
(see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-hmn 6000 ppm
skn-rbt 500 mg open MLD
eye-rbt 50 mg MOD
eye-rbt 500 mg/24H MLD
eye-gpg 10 ug MLD
Standards and Regulations: DOT-Hazard: Combustible liquid; Label: None
DOT-IMO: Flammable or Combustible liquid; Label:
Flammable liquid
Status: EPA TSCA Chemical Inventory, 1989
EPA TSCA Section 8(e) Status Report 8EHQ-0381-0386
EPA TSCA Test Submission (TSCATS) Data Base, April 1990
NIOSH Current Intelligence Bulletin, #39
NIOSH Analytical Methos: see Alcohols, IV, 1403
OSHA Analytical Method #53
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Ethylene glycol monoethyl ether
UN/ID NUMBER: UN1171
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 309, Y309 MAXIMUM QUANTITY: 60 L, 10 L
CARGO : PKG. INSTR.: 310 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
Solvent for nitrocellulose, lacquers, and dopes; in varnish removers,
cleansing solutions, dye baths; finishing leather; water pigments and
dye solution; increasing stability of emulsions. Solvent for natural
and synthetic resins; mutual solvent for formulation of soluble oils;
dyeing and printing textiles; anti-icing additive for aviation fuels;
and antifreeze for explosives.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This material may cause irritation to the eyes and mucous membranes and is
readily absorbed through the skin.
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
Permeation Test Results For The Neat (Undiluted) Chemical:
The permeation test results for the neat (undiluted) chemical are given
below. The breakthrough times of this chemical are given for each glove type
tested. The table is a presentation of actual test results, not specific
recommendations or suggestions. Avoid glove types which exhibit breakthrough
times of less than the anticipated task time plus an adequate safety factor.
If this chemical makes direct contact with your glove, or if a tear, puncture
or hole develops, replace them at once.
Glove Type Model Number Thickness Breakthrough Time
Butyl rubber North B-174 0.76 mm 480 min
PVA Edmont 25-545 0.76 mm 30 min
PVC Edmont 34-100 0.20 mm 4 min
Latex Ackwell 5-109 0.15 mm 1 min
Nitrile Edmont 37-155 0.38 mm 88 min
Neoprene Edmont 29-870 0.64 mm 223 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and keep it away from oxidizing materials. STORE AWAY FROM SOURCES OF
IGNITION.
SPILLS AND LEAKAGE:
If you should spill this chemical, use absorbent paper to pick up
all liquid spill material. Seal the absorbent paper, as well as any
of your clothing which may be contaminated, in a vapor-tight plastic
bag for eventual disposal. Wash any surfaces you may have contaminated
with a soap and water solution. Do not reenter the contaminated area
until the Safety Officer (or other responsible person) has verified
that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include irritation of the eyes,
including conjunctival and corneal irritation; irritation of the mucous
membranes and upper respiratory tract; central nervous system depression;
kidney injury; hematuria; vertigo; unconsciousness; cyanosis; tachy-
pneumonary edema; and tonic-clonic spasms.
SOURCES
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