NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
ETHYLENE GLYCOL DIMETHYL ETHER
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IDENTIFIERS
CATALOG ID NUMBER: 002206
CAS NUMBER: 110-71-4
BASE CHEMICAL NAME: ETHYLENEGLYCOLDIMETHYLETHER
PRIMARY NAME: ETHYLENE GLYCOL DIMETHYL ETHER
CHEMICAL FORMULA: C4H10O2
STRUCTURAL FORMULA: CH3OCH2CH2OCH3
WLN: 10201
SYNONYMS:
1,2-DIMETHOXYETHANE
DIMETHOXYETHANE
ALPHA,BETA-DIMETHOXYETHANE
DIMETHYLCELLOSOLVE
ETHYLENE DIMETHYL ETHER
MONOETHYLENE GLYCOL DIMETHYL ETHER
2,5-DIOXAHEXANE
1,2-ETHANEDIOL, DIMETHYL ETHER
GLYCOL DIMETHYL ETHER
ANSUL ETHER 12'
ANSUL ETHER 121
DME
DME (SOLVENT)
EGDME
GDME
GLYME
MONOGLYME
UN 2252
ETHANE, 1,2-DIMETHOXY-
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear colorless liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 90.12
SPECIFIC GRAVITY: 0.86285 @ 20/4 C [031]
DENSITY: 0.8683 g/mL @ 20 C [062]
MP (DEG C): -58 C [017,031,058,275]
BP (DEG C): 85 C [036,058,269,275]
SOLUBILITIES:
WATER : >=100 mg/mL @ 22 C (RAD)
DMSO : >=100 mg/mL @ 22 C (RAD)
95% ETHANOL : >=100 mg/mL @ 22 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 22 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Benzene: Soluble [017]
Ether: Soluble [017,047]
Hydrocarbons: Soluble [025,031,062]
Petroleum ether: Soluble [205]
Alcohol: Miscible [043]
VOLATILITY:
Vapor pressure: 40 mm Hg @ 10.7 C; 60 mm Hg @ 19.7 C [038]
Vapor density : 3.1 [058,371]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 0 C (32 F) [269,275]. It is flammable.
Fires involving this material can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher. A water spray may also be used [036,269]. The
autoignition temperature is 202 C (395 F) [371,451].
UEL: 10.4% [058] LEL: 1.6% [058]
REACTIVITY:
This chemical is incompatible with strong oxidizers [058,269]. It is also
incompatible with strong acids [269]. Explosive decomposition has occurred
with lithium tetrahydroaluminate [043,066]. It can form peroxides from con-
tact with oxygen [058].
STABILITY:
This chemical is liable to form explosive peroxides on exposure to air and
light [036]. NMR stability screening indicates that solutions of this chemical
in DMSO are stable for 24 hours (RAD).
OTHER PHYSICAL DATA:
Specific gravity: 0.86877 @ 15/4 C; 0.8602 @ 33/4 C; 0.8692 @ 20/20 C [031]
Melting point also reported as -71 C [025,031]
Freezing point: -69 C [062,371]
Boiling point: 20 C @ 61.2 mm Hg; 16 C @ 50 mm Hg; -14 C @ 10 mm Hg [031]
Vapor pressure: 61.2 mm Hg @ 20 C [058]; 100 mm Hg @ 31.8 C, 200 mm Hg @ 50 C,
400 mm Hg @ 70.8 C [038]
Refractive index: 1.3796 @ 20 C [017,205]; 1.3739 @ 24 C [031,043]
Sharp ethereal odor [025,031,036,043]
pH: 8.2 [062]
100% Volatile by volume [058]
UV max (in water): 400-350 nm, 300 nm, 250 nm, 220 nm (A = 0.01, 0.03, 0.20,
1.0) [275]
Burning rate: 4.9 mm/min. [371]
Critical temperature: 263 C [371]
Critical pressure: 38.2 atmospheres [371]
Latent heat of vaporization: 74.6 cal/g [371]
Heat of combustion: -6680 cal/g [371]
Evaporation rate (butyl acetate = 1): 4.99 [058]
TOXICITY
NIOSH REGISTRY NUMBER: KI1451000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 5-15 gm/kg [371]
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Experimental reproductive effects. Readily forms an explosive peroxide.
CARCINOGENICITY: Not available
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
Not available |
TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-mus 1960 mg/kg (7-10D preg)
TDLo: orl-mus 1400 mg/kg (7-10D preg)
TDLo: orl-mus 361 mg/kg (11D preg)
TDLo: orl-mus 16 gm/kg (7-14D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 2
Flammability (F): 2
Reactivity (R): 0
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F2: Materials which must be moderately heated before ignition will occur
(see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Standards and Regulations: DOT-IMO: Flammable liquid; Label: Flammable liquid
Status: EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, September 1989
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): 1,2-Dimethoxyethane
UN/ID NUMBER: UN2252
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 305, Y305 MAXIMUM QUANTITY: 5 L, 1 L
CARGO : PKG. INSTR.: 307 MAXIMUM QUANTITY: 60 L
SPECIAL PROVISIONS: None
USES:
This compound is used as a solvent. It is also used to facilitate the
formation of alkali metal-hydrocarbon adducts and is used in the Reformatsky
reaction with methyl gamma-bromocrotonate.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may be harmful by inhalation [036,058,269]. It may also be
harmful by ingestion or skin absorption [058,269]. It may cause irritation
[025,058,269]. When heated to decomposition it emits toxic fumes of carbon
monoxide and carbon dioxide [058,269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-131 0.30 mm 480 min
Neoprene Edmont NEOX Unknown 240 min
Nitrile North LA 102G 0.28 mm 200 min
PE/EVOH/PE Safety4 4H 0.07 mm 240 min
RECOMMENDED RESPIRATOR:
When working with this chemical, wear a full face chemical cartridge
respirator equipped with the appropriate organic vapor cartridges. If that is
not available, a half face respirator similarly equipped plus airtight goggles
can be substituted. However, please note that half face respirators provide a
substantially lower level of protection than do full face respirators.
OTHER: Not available
STORAGE PRECAUTIONS:
You should protect this chemical from exposure to light. Keep the
container tightly closed under an inert atmosphere, and store it in an
explosion-proof refrigerator. STORE AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Seal the absorbent
paper, as well as any of your clothing which may be contaminated, in a vapor-
tight plastic bag for eventual disposal. Wash any surfaces you may have
contaminated with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly with
soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being
aspirated into the victim's lungs during vomiting which increases the medical
problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound via ingestion may include nausea
and vomiting [058,371]. Other symptoms by ingestion include cramps, weakness,
unconsciousness and coma [371]. Abdominal pain and central nervous system
depression may also result. Ingestion of large amounts may lead to damage to
the blood, liver and kidneys [058]. Inhalation of this compound may cause
dizziness or difficult breathing [371]. Other symptoms via inhalation include
mild irritation, coughing and sneezing. Skin contact may result in local
inflammation. Prolonged or large area contact may cause central nervous system
effects. Irritating effects from eye contact may cause pain, redness, blurred
vision or tearing. Prolonged exposure may lead to hemolysis and liver or kid-
ney damage. It may cause adverse reproductive effects [058].
Ingestion of this class of compounds causes symptoms of alcohol intoxi-
cation soon progressing to cyanosis, headache, tachypnea, tachycardia, hypo-
tension, pulmonary edema, muscle tenderness, stupor, prostration, unconscious-
ness with convulsions and possible hypoglycemia. Death may occur within a
few hours from respiratory failure or within the first 24 hours from pulmonary
edema. Persons who have prolonged coma or convulsions may have irreversible
brain damage. Hypocalcemic tetany has also been reported. Overdosage may
cause intravascular hemolysis. Repeated doses may cause oliguria progressing
to anuria and uremia [301].
SOURCES
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