NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000735
CAS NUMBER: 109-89-7
BASE CHEMICAL NAME: DIETHYLAMINE
PRIMARY NAME: DIETHYLAMINE
CHEMICAL FORMULA: C4H11N
STRUCTURAL FORMULA: CH3CH2NHCH2CH3
WLN: 2M2
SYNONYMS:
DEN
DIETHAMINE
N-ETHYLETHANAMINE
N,N-DIETHYLAMINE
DEA
UN 1154
ETHANAMINE, N-ETHYL-
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless, watery liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 73.14
SPECIFIC GRAVITY: 0.7074 @ 20/4 C [033,205]
DENSITY: 0.7074 g/mL @ 20 C [421]
MP (DEG C): -50 C [033,102,205,275]
BP (DEG C): 55.5 C [033,043,205,371]
SOLUBILITIES:
WATER : >=100 mg/mL @ 17 C (RAD)
DMSO : >=100 mg/mL @ 17 C (RAD)
95% ETHANOL : >=100 mg/mL @ 17 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 17 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Alcohol: Miscible [033]
Ether: Soluble [017,047]
Most organic solvents: Miscible [058,062,421]
VOLATILITY:
Vapor pressure: 195 mm Hg @ 20 C [058,102,421,430]; 200 mm Hg @ 21 C [038]
Vapor density : 2.53 [043,055,058]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of -28 C (-20 F) [205,269,275]. It
is flammable. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. The autoignition temperature
is 312 C (594 F) [036,043,371,451].
UEL: 10.1% [036,066,371,451] LEL: 1.8% [036,043,066,451]
REACTIVITY:
This chemical is strongly alkaline [033,058,062,451]. It is incom-
patible with strong oxidizers [058,102,269,346]. It is also incompatible
with strong acids [102,269,346]. Violent reactions occur with sulfuric
acid [043]. Cellulose nitrate has spontaneously ignited on contact with
this compound [043,066]. Contact with dicyanofurazan or dicyanofuroxan is
instantaneously explosive [066]. This chemical will attack some forms of
plastics, rubber and coatings [102].
STABILITY:
This chemical is sensitive to heat [043,058,102]. It may be sensitive
to prolonged exposure to air.
OTHER PHYSICAL DATA:
Specific gravity: 0.711 @ 18/4 C [029,055]; 0.7062 @ 20/20 C [062]
Vapor pressure: 60 mm Hg @ -4 C; 100 mm Hg @ 6 C; 760 mm Hg @ 55.5 C [038]
Vapor pressure: 290 mm Hg @ 30 C [055]; 400 mm Hg @ 38 C [038,043]
Ammoniacal odor [036,043,058,451]
Odor threshold: 0.14 ppm [102,371]
pKa: 11.1 [029]
pKb: 3 [430]
Refractive index: 1.3873 @ 18 C [029]; 1.3864 @ 20 C [033,047,205]
Forms a dihydrate (freezing point: -19 C) [029]
log P octanol: 0.43-0.57 [055]
Burning rate: 6.7 mm/min [371]
Critical temperature: 223.5 C [371]
Critical pressure: 36.6 atmospheres [371]
Liquid surface tension: 20.05 dynes/cm @ 20 C [371]
Latent heat of vaporization: 93 cal/g [371]
Heat of combustion: -9994 cal/g [371]
Evaporation rate (butyl acetate = 1): 16.9 [058,102]
100% volatile by volume [058]
TOXICITY
NIOSH REGISTRY NUMBER: HZ8750000
TOXICITY:
typ. dose mode specie amount units other
LC50 ihl mam 5000 mg/m3
LCLo ihl mus 3 gm/m3
LC50 ihl rat 4000 ppm/4H
LDLo ipr rat 50 mg/kg
LD50 orl mus 500 mg/kg
LD50 orl rat 540 mg/kg
LD50 skn rbt 820 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Moderately toxic by ingestion, inhalation and skin contact. A skin
and severe eye irritant.
CARCINOGENICITY: Not available
MUTATION DATA: See RTECS printout for data
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 25 ppm [015,327,545,610]
Final Limit: PEL-TWA 10 ppm; STEL 25 ppm [015,545,610]
ACGIH: TLV-TWA 10 ppm; STEL 25 ppm [015,415,421,610]
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 2
Flammability (F): 3
Reactivity (R): 0
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F3: Materials which can be ignited under almost all normal temperature
conditions (see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 10 mg/24H open MLD
skn-rbt 500 mg open MLD
skn-rbt 100 mg/24H MOD
eye-rbt 50 ug open SEV
Review: Toxicology Review
Standards and Regulations: DOT-Hazard: Flammable liquid; Label: Flammable
liquid
Status: EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, January 1990
OSHA Analytical Method #41
IDLH value: 2000 ppm [346,371,430]
Estimated fatal dose: 20 g [301]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Diethylamine
UN/ID NUMBER: UN1154
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 306, Y306 MAXIMUM QUANTITY: 5 L, 1 L
CARGO : PKG. INSTR.: 308 MAXIMUM QUANTITY: 60 L
SPECIAL PROVISIONS: None
USES:
This compound is used in organic synthesis and in the manufacture
of diethyldithiocarbamate and thiurams (rubber processing accelerators),
diethylaminoethanol (medicinal intermediate), diethylaminopropylamine
(epoxy curing agent), N,N-diethyl-m-toluamide and other pesticides,
2-diethylaminoethylmethacrylate and drugs. It is used as a selective
solvent. It is also used in textile specialties, in rubber and petroleum
industries, in flotation agents, in resins, in dyes, in polymerization
inhibitors, in electroplating and in corrosion inhibitors.
COMMENTS:
This compound is usually encountered as an aqueous solution [029].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is toxic by ingestion, inhalation or skin absorption
[058,062,102,269]. It is readily absorbed through the skin [102,269]. It
is an irritant of the skin, eyes, mucous membranes and respiratory tract
[033,036,346,371]. It is also corrosive [058,269,275]. Flashback along
the vapor trail may occur [371]. When heated to decomposition it emits
irritating vapors and toxic fumes of carbon monoxide, carbon dioxide and
nitrogen oxides [043,058,269,371].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Permeation Test Results For The Neat (Undiluted) Chemical:
The permeation test results for the neat (undiluted) chemical are given
below. The breakthrough times of this chemical are given for each glove type
tested. The table is a presentation of actual test results, not specific
recommendations or suggestions. Avoid glove types which exhibit breakthrough
times of less than the anticipated task time plus an adequate safety factor.
If this chemical makes direct contact with your glove, or if a tear, puncture
or hole develops, replace them at once.
Glove Type Model Number Thickness Breakthrough Time
Viton North F-091 0.25 mm 20 min
Butyl rubber North B-174 0.86 mm 40 min
Nitrile Edmont 37-155 0.41 mm 5 min
PVC Edmont 34-100 0.20 mm 1 min
RECOMMENDED RESPIRATOR:
When working with this chemical, wear a NIOSH-approved full face
chemical cartride respirator equipped with the appropriate organic vapor
cartridges. If that is not available, a half face respirator similarly
equipped plus airtight goggles can be substituted. However, please note
that half face respirators provide a substantially lower level of protection
than do full face respirators.
OTHER: Not available
STORAGE PRECAUTIONS:
You should keep this material in a tightly closed container under an
inert atmosphere, and store it in an explosion-proof refrigerator. STORE
AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Seal the absorbent
paper, as well as any of your clothing which may be contaminated, in a vapor-
tight plastic bag for eventual disposal. Wash any surfaces you may have
contaminated with a soap and water solution. Do not reenter the contaminated
area until the Safety Officer (or other responsible person) has verified that
the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature (>2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes
of the mouth, throat, and esophagus and volatile chemicals have a high risk of
being aspirated into the victim's lungs during vomiting. Thus, the risk of
increasing the medical problems by inducing vomiting of a volatile corrosive
chemical is very high.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound include irritation and burns of
the skin, eyes and respiratory tract [269,371]. It also causes irritation
of the mucous membranes [033,102]. It is corrosive and extremely destructive
to tissues of the mucous membranes and upper respiratory tract, eyes and skin
[269]. Other symptoms of exposure include coughing, chest pains and difficulty
in breathing [102,269]. It may cause swelling of the eye, causing foggy vision
and appearance of halos around lights. Eye contact may also cause pain [102].
Exposure may cause smarting and reddening of the skin. High vapor concentra-
tions can cause asphyxiation [371]. Erythema and blistering have been reported
[301]. Topical application to skin can cause necrosis and vesiculation [102].
Severe corneal damage may occur from contact with eyes. Repeated exposures
may cause tracheitis, bronchitis, pneumonitis and pulmonary edema [421]. Other
eye effects from exposure to this compound include edema of the epithelium of
the cornea and blue hazy vision due to a subtle temporary disturbance of the
corneal epithelium [099].
Ingestion of strong alkalies causes severe pain, vomiting, diarrhea and
collapse. The vomitus contains blood and desquamated mucosal lining. If
death does not occur in 24 hours, there may be improvement then sudden onset
of severe abdominal pain, board-like abdominal rigidity and rapid fall of blood
pressure indicating delayed gastric or esophageal perforation. Other symptoms
include esophageal stricture and chronic dermatitis [301].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. HZ8750000.
April 5, 1990.
[017] Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 67th Ed. CRC Press, Inc. Boca Raton,
FL. 1986. p. C-244, #6092.
[029] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed. and
Supplements. Chapman and Hall. New York. 1988. Vol. 2, p. 1799,
#D-03321.
[033] Budavari, Susan, Ed. The Merck Index. 11th Ed. Merck and Co., Inc.
Rahway, NJ. 1989. p. 491, #3100.
[036] Bretherick, L., Ed. Hazards in the Chemical Laboratory. 4th Ed.
The Royal Society of Chemistry. London. 1986. pp. 288-289.
[038] Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 522.
[039] Boublik, T., V. Fried and E. Hala. The Vapor Pressures of Pure
Substances. p. 184.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. II, pp. 1195-1196, #DHJ200.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 555, #D00359.
[055] Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
pp. 519-520.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. April/May
1988. #2654-004, D-04; #3800-410, E-09.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 387.
[066] Bretherick, L. Handbook of Reactive Chemical Hazards. 3rd Ed.
Butterworths. London. 1985. p. 476.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[099] Grant, W. Morton, M.D. Toxicology of the Eye. 3rd Ed. Charles
C. Thomas, Publisher. Springfield, IL. 1986. pp. 75, 333.
[102] U.S. Department of Health and Human Services and U.S. Department
of Labor. NIOSH/OSHA Occupational Health Guidelines for Chemical
Hazards. 3 Vols. DHHS (NIOSH) Publication No. 81-123. January,
1981. Volume 1.
[105] The Society of Dyers and Colourists. Colour Index. Vols. 1-7.
The Society of Dyers and Colourists. Yorkshire, England.
American Association of Textile Chemists and Colorists.
Research Triangle Park, NC. 1971-1982. Vol. 4, p. 4762.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[195] Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds. CFTA Cosmetic
Ingredient Dictionary. 3rd Ed. The Cosmetic, Toiletry and
Fragrance Assn. Inc. Washington. 1982. p. 79.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-301, #d518.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 656, #A.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 519, #11,000-0.
[301] Dreisbach, R.H. Handbook of Poisoning: Prevention, Diagnosis
and Treatment. 11th Ed. Lange Medical Publications. Los
Altos, CA. 1983. pp. 230-232.
[327] Office of the Federal Register National Archives and Records
Administration. Code of Federal Regulations, Title 29, Labor,
Parts 1900 to 1910. U.S. Government Printing Office.
Washington. 1988. p. 707.
[346] Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
2nd Ed. Noyes, Publications. Park Ridge, NJ. 1985. pp. 342-343.
[371] U.S. Coast Guard, Department of Transportation. CHRIS
Hazardous Chemical Data. U.S. Coast Guard. Washington,
D.C. 1985. Volume 1.
[401] Nutt, A. R. Toxic Hazards of Rubber Chemicals. Elsevier
Applied Science Publishers. New York. 1984. pp. 45, 164.
[415] American Conference of Governmental Industrial Hygienists.
Threshold Limit Values and Biological Exposure Indices
for 1988-1989. American Conference of Governmental
Industrial Hygienists. Cincinnati, OH. 1988. p. 18.
[421] American Conference of Governmental Industrial Hygienists.
Documentation of the Threshold Limit Values. 5th Ed.
American Conference of Governmental Industrial Hygienists.
Cincinnati, OH. 1986. p. 197.
[430] Clayton, G.D. and F.E. Clayton, Eds. Patty's Industrial Hygiene
and Toxicology. Vol. 2. Third Revised Edition. John Wiley
and Sons. New York. 1981. Vol. IIB, pp. 3137, 3139, 3145-
3147, 3152-3153.
[451] National Fire Protection Association. Fire Protection Guide on
Hazardous Materials. 9th Ed. National Fire Protection
Association. Quincy, MA. 1986. pp. 325M-35, 49-40 to 49-41.
[545] Office of the Federal Register National Archives and Records
Administration. Federal Register, Dept. of Labor, Part III.
U.S. Government Printing Office. Washington. January 19, 1989.
p. 2934.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 44.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
-------------------------------------------------------------