NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000136
CAS NUMBER: 108-94-1
BASE CHEMICAL NAME: CYCLOHEXANONE
PRIMARY NAME: CYCLOHEXANONE
CHEMICAL FORMULA: C6H10O
STRUCTURAL FORMULA:
WLN: L6VTJ
SYNONYMS:
KETOCYCLOHEXANE
OXOCYCLOHEXANE
ANONE
HEXANON
HYTROL O
KETOHEXAMETHYLENE
NADONE
PIMELIC KETONE
PIMELIN KETONE
SEXTONE
NCI-C55005
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTIONS: LITERATURE: Clear, colorless liquid
REPOSITORY: Clear, colorless liquid
MOLECULAR WEIGHT: 98.16
SPECIFIC GRAVITY: 0.9478 @ 20/4 C
DENSITY: 3.4
MP (DEG C): -16 C
BP (DEG C): 155.6 C @ 760 mm Hg
SOLUBILITIES:
WATER : 50-100 mg/mL @ 18 C (RAD)
DMSO : >=100 mg/mL @ 18 C (RAD)
95% ETHANOL : >=100 mg/mL @ 18 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 18 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Soluble
Organic solvents: Miscible
ETHER : Soluble
BENZENE: Soluble
VOLATILITY: Vapor pressure: 5.2 mm Hg @ 25 C; 10 mm Hg @ 38.7 C
Vapor density: 3.4
FLAMMABILITY(FLASH POINT):
The flash point of this compound is 44 C (111 F) and it is combustible.
Fires involving this compound may be extinguished with a carbon dioxide, dry
chemical or Halon extinguisher. The autoignition temperature is 420 C (788 F).
UEL: 8.1% LEL: 1.2%
REACTIVITY:
This chemical forms an explosive peroxide with H2O2, and reacts vigorously
with oxidizing materials.
STABILITY: This material should be protected from moisture.
OTHER PHYSICAL DATA:
Acetone-like odor
Odor threshold: 0.12 ppm
Refractive index: 1.4507 @ 20 C
Critical temperature: 356 C
Critical pressure: 38 atm
Burning rate: 4.2 mm/min
Latent heat of vaporization: 91 cal/g
Heat of combustion: -8570 cal/g
Hygroscopic
ulc: 35-40
TOXICITY
NIOSH REGISTRY NUMBER: GW1050000
TOXICITY:
typ. dose mode specie amount unit other
TCLo ihl hmn 75 ppm
LCLo ihl rat 2000 ppm/4H
LD50 scu rat 2170 mg/kg
LD50 ipr mus 1350 mg/kg
LD50 orl rat 1535 mg/kg
LD50 orl mus 1400 mg/kg
LDLo scu mus 1300 mg/kg
LDLo ivn dog 630 mg/kg
LDLo orl rbt 1600 mg/kg
LD50 skn rbt 948 mg/kg
TCLo ihl gpg 400 ppm/4H
LDLo ipr gpg 760 mg/kg
LDLo scu frg 1900 mg/kg
AQTX/TLM96: 100-10 ppm
SAX TOXICITY EVALUATION:
THR: MODERATE via oral, inhalation, subcutaneous and intraperitoneal routes.
MILD narcotic properties have also been described. It is a skin and eye
irritant.
CARCINOGENICITY:
Review: IARC Cancer Review: Animal Inadequate Evidence
IARC: Not classifiable as a human carcinogen (Group 3) [610]
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
cyt-hmn:leu 100 umol/L |
TERATOGENICITY:
Reproductive Effects Data:
TCLo: ihl-rat 105 mg/m3/4H (1-20D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 50 ppm [610]
Final Limit: PEL-TWA 25 ppm (skin) [610]
ACGIH: TLV-TWA 25 ppm (skin) [610]
NIOSH Criteria Document: Recommended Exposure Limit to this compound-air:
TWA 25 ppm/10H [610]
NFPA Hazard Rating: Health (H): 1
Flammability (F): 2
Reactivity (R): 0
H1: Materials only slightly hazardous to health (see NFPA for details).
F2: Materials which must be moderately heated before ignition will occur
(see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
eye-hmn 75 ppm
skn-rbt 500 mg open MLD
eye-rbt 4740 ug SEV
Standards and Regulations: IMO: Flammable or Combustible liquid; Label:
Flammable liquid
Status: "NIOSH Manual of Analytical Methods" Vol. 2 S19
Reported in EPA TSCA Inventory, 1980
EPA TSCA 8(a) preliminary assessment information Final Rule
Meets criteria for proposed OSHA Medical Records Rule
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Cyclohexanone
UN/ID NUMBER: UN1915
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 309, Y309 MAXIMUM QUANTITY: 60 L, 10 L
CARGO : PKG. INSTR.: 310 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
Solvent, swelling agent for PVC, synthetic intermediate, H acceptor in
Oppenauer oxidations, degreasing of metals, paint and varnish removers,
spot removers, polishes, nylon.
COMMENTS:
A comparatively harmless solvent obtained from cyclohexanol by
catalytic dehydrogenation or oxidation or from cyclohexane by oxidation.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is an irritant and can cause first degree burns on short
exposure. It is a moderate fire hazard when exposed to heat or flame. When
heated to decomposition this compound emits acrid smoke and irritating fumes.
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemical:
Recommendations based on permeation test results are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): Butyl rubber, PVA (to 420 minutes)
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
Splash proof safety goggles should be worn while handling this
chemical. Alternatively, a full face respirator, equipped as above,
may be used to provide simultaneous eye and respiratory protection.
OTHER: Not available
STORAGE PRECAUTIONS:
You should store this chemical under refrigerated temperatures,
and protect it from moisture. STORE AWAY FROM SOURCES OF IGNITION.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION.
Then, use absorbent paper to pick up all liquid spill material. Seal
the absorbent paper, as well as any of your clothing which may be con-
taminated, in a vapor-tight plastic bag for eventual disposal. Wash any
surfaces you may have contaminated with a soap and water solution. Do
not reenter the contaminated area until the Safety Officer (or other re-
sponsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes
of the mouth, throat, and esophagus and, in addition, have a high risk of
being aspirated into the victim's lungs during vomiting which increases the
medical problems.
If the victim is conscious and not convulsing, give 1 or 2 glasses of
water to dilute the chemical and IMMEDIATELY call a hospital or poison control
center. IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim
IMMEDIATELY to a hospital.
SYMPTOMS:
Symptoms following exposure to this compound may include eyes, throat, skin
and mucous membrane irritation, degenerative liver and kidney changes, irrita-
tion of the central nervous system, narcosis, cataracts and lymphoid changes.
FIREFIGHTING: Not available
SOURCES
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American Conference of Governmental Industrial Hygenists.
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