NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000039
CAS NUMBER: 108-86-1
BASE CHEMICAL NAME: BROMOBENZENE
PRIMARY NAME: BROMOBENZENE
CHEMICAL FORMULA: C6H5Br
STRUCTURAL FORMULA: Not printable
WLN: ER
SYNONYMS:
MONOBROMOBENZENE
NCI-C55492
PHENYLBROMIDE
PHENYL BROMIDE
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Clear colorless liquid
REPOSITORY: Clear colorless liquid
MOLECULAR WEIGHT: 157.02
SPECIFIC GRAVITY: 1.4950 @ 20/4 C
DENSITY: 1.497 g/mL
MP (DEG C): -31 C
BP (DEG C): 156 C
SOLUBILITIES:
WATER : <1 mg/mL @ 20.5 C (RAD)
DMSO : >=100 mg/mL @ 20.5 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20.5 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 20.5 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Chloroform: Miscible
Carbon tetrachloride: Soluble
Ether: Soluble
Benzene: Soluble
Petroleum hydrocarbons: Miscible
VOLATILITY:
Vapor pressure: 5 mm Hg @ 27.8 C; 10 mm Hg @ 40 C; 20 mm Hg @ 53.8 C
Vapor density : 5.41
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 51 C (123.8 F). It is combustible.
Fires involving this material can be controlled with a dry chemical,
carbon dioxide or Halon extinguisher. The autoignition temperature is
566 C (1051 F).
UEL: Not available LEL: Not available
REACTIVITY:
This compound may react with oxidizing agents and sodium bromobutane.
STABILITY:
This compound may be sensitive to light. Solutions of this chemical in water,
DMSO, 95% ethanol or acetone should be stable for 24 hours under normal lab
conditions (RAD).
OTHER PHYSICAL DATA:
Refractive index: 1.5597 @ 20 C
A mobile liquid with an aromatic odor
Fire point: 155 C (311 F)
Specific gravity: 1.5220 @ 0/4 C; 1.5083 @ 10/4 C
Critical pressure: 655 psia
Critical temperature: 397 C
Specific heat: 0.2368 @ 26.84 C
Viscosity: 1.124 centipoise @ 20 C
TOXICITY
NIOSH REGISTRY NUMBER: CY9000000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 2699 mg/kg
LC50 ihl rat 20411 mg/m3
LD50 ipr mus 1000 mg/kg
LC50 ihl mam 14400 mg/m3
LD50 ipr mam 2030 mg/kg
LD50 orl mus 2700 mg/kg
LC50 ihl mus 21 gm/m3/2H
LD50 scu mus 2000 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: MODERATE via oral, inhalation and intraperitoneal routes. An irritant
to the eyes and mucous membranes. MUTATION data.
CARCINOGENICITY:
Status: NTP Carcinogenesis Studies; on test, March 1986
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
dnr-esc 250 mg/L |
TERATOGENICITY: Not available
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 2
Flammability (F): 2
Reactivity (R): 0
H2: Materials hazardous to health, but areas may be entered freely with
full-faced mask self-contained breathing apparatus which provides
eye protection (see NFPA for details).
F2: Materials which must be moderately heated before ignition will occur
(see NFPA for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Standards and Regulations: DOT-Hazard: Combustible liquid; Label: None
DOT-IMO: Flammable or combustible liquid;
Label: Flammable liquid
Status: Reported in EPA TSCA Inventory, 1983
Meets criteria for proposed OSHA Medical Records Rule
EPA Genetic Toxicology Program, January 1984
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Bromobenzene
UN/ID NUMBER: UN2514
HAZARD CLASS: 3 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Flammable liquid
PACKAGING: PASSENGER: PKG. INSTR.: 309, Y309 MAXIMUM QUANTITY: 60 L, 10 L
CARGO : PKG. INSTR.: 310 MAXIMUM QUANTITY: 220 L
SPECIAL PROVISIONS: None
USES:
Organic synthesis, expecially to make phenyl magnesium bromide; solvent,
expecially for crystals on a large scale and where a heavy liquid is
desirable; and motor oil additive.
COMMENTS: Not available
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is an irritant of the skin, eyes and mucous membranes and can
be absorbed through the skin. When heated to decomposition it emits toxic
fumes of carbon monoxide, carbon dioxide, and hydrogen bromide gas. High
vapor concentrations may be anesthetic.
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemical:
Recommendations based on permeation test results are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): Viton, Polyvinyl alcohol
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should protect this material from exposure to light, and store
it in a refrigerator.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT:
You should dispose of all waste and contaminated materials
associated with this chemical as specified by existing local,
state and federal regulations concerning hazardous waste disposal.
It is suggested that your contaminated materials should be destroyed
by incineration in a special, high temperature ( >2000 degrees F),
chemical incinerator facility.
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound may include irritation of the skin,
eyes and stomach; central nervous system depression and liver necrosis.
SOURCES
SOURCES:
Weiss, G., Ed. Hazardous Chemicals Data Book. Noyes Data
Corporation. Park Ridge, NJ. 1980.
Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of
Chemistry and Physics. 65th Ed. CRC Press, Inc. Boca Raton,
FL. 1984. p. C-130, #1921.
Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 193, #1377.
Bretherick, L., Ed. Hazards in the Chemical Laboratory. 3rd Ed.
The Royal Society of Chemistry. London. 1981. pp. 208-209.
Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. p. 523.
Boublik, T., V. Fried and E. Hala. The Vapor Pressures of Pure
Substances. p. 592.
Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 2178.
Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. 1, p. 156, #B00485.
Midwest Research Institute. MRI Report for Bromobenzene.
Kansas City, MO. August 7, 1978.
Arthur D. Little, Inc. Health and Safety Package for
Bromobenzene. Arthur D. Little, Inc. Cambridge, MA.
January 27, 1983.
Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
pp. 290-291.
Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. #1402-011 B-7.
Bretherick, L. Handbook of Reactive Chemical Hazards. 3rd Ed.
Butterworths. London. 1985. p. 522.
U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. 1983. Listed.
Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. p. II-169, #392.
Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-160, #b371.
Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 232, #A.
Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1986. p. 198, #23,987-9.
Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens.
2nd Ed. Noyes, Publications. Park Ridge, NJ. 1985. p. 147.
Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
Hawley, G.G., Ed. The Condensed Chemical Dictionary. 10th Ed.
Van Nostrand Reinhold. New York. 1981. pp. 150-151.
Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.
Chapman and Hall. New York. 1982. Vol. 1, p. 753, #B-01916.
Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. CY9000000.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 43.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. October 3, 1990.
Listed.
-------------------------------------------------------------