NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 001343
CAS NUMBER: 108-45-2
BASE CHEMICAL NAME: PHENYLENEDIAMINE,M-
PRIMARY NAME: M-PHENYLENEDIAMINE
CHEMICAL FORMULA: C6H8N2
STRUCTURAL FORMULA: C6H4(NH2)2
WLN: ZR CZ
SYNONYMS:
1,3-BENZENEDIAMINE
M-DIAMINOBENZENE
M-AMINOANILINE
3-AMINOANILINE
M-BENZENEDIAMINE
C.I. 76025
DEVELOPER 11
DEVELOPER C
DEVELOPER H
DEVELOPER M
1,3-DIAMINOBENZENE
DIRECT BROWN BR
DIRECT BROWN GG
METAPHENYLENEDIAMINE
1,3-PHENYLENEDIAMINE
APCO 2330
META-PHENYLENEDIAMINE
META-DIAMINOBENZENE
MPD
UN1673
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless to brown or black crystals or lumps
REPOSITORY: Brown solid
MOLECULAR WEIGHT: 108.14
SPECIFIC GRAVITY: 1.0696 @ 58/4 C [016,047]
DENSITY: 1.14 g/mL @ 15 C [058]
MP (DEG C): 63-64 C [016,047,055,395]
BP (DEG C): 282-284 C [016,055,269,395]
SOLUBILITIES:
WATER : <1 mg/mL @ 19 C (RAD)
DMSO : >=100 mg/mL @ 19 C (RAD)
95% ETHANOL : >=100 mg/mL @ 19 C (RAD)
METHANOL : Soluble [033,043,395]
ACETONE : >=100 mg/mL @ 19 C (RAD)
TOLUENE : Very slightly soluble [033,043]
OTHER SOLVENTS:
Chloroform: Soluble [033,043,205,395]
Dimethylformamide: Soluble [033,395]
Methyl ethyl ketone: Soluble [033,395]
Carbon tetrachloride: Slightly soluble [033,043]
Dioxane: Soluble [033,395]
Isopropanol: Slightly soluble [033]
Dibutyl phthalate: Slightly soluble [033]
Xylene: Very slightly soluble [033]
Butanol: Very slightly soluble [033]
Ether: Slightly soluble [033,043,205]
Benzene: Very slightly soluble [033,043,205]
Alcohol: Soluble [016,062,205]
Aqueous sodium hydroxide: Soluble [105]
VOLATILITY:
Vapor pressure: 1 mm Hg @ 99.8 C [038,043,395]; 0.0018 mm Hg @ 25 C [058]
Vapor density : 3.7 [058]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 138 C (280 F) [058]. It is combus-
tible. Fires involving this material can be controlled with a dry chemical,
carbon dioxide or Halon extinguisher. A water spray may also be used [058,
269]. The autoignition temperature is 560 C (1040 F). Dust may form explosive
mixtures in air [058]
UEL: Not available LEL: Not available
REACTIVITY:
This compound is incompatible with oxidizing agents [058,269]. It is also
incompatible with acids, acid chlorides, acid anhydrides and chloroformates
[269].
STABILITY:
This compound is sensitive to light [269]. It turns red on exposure to
air [033,055,062]. This compound darkens on storage. Moist air and excess
heat cause it to degrade [058]. Solutions of this chemical in water, DMSO, 95%
ethanol or acetone should be stable for 24 hours under normal lab conditions
(RAD).
OTHER PHYSICAL DATA:
Fire point: 175 C [033]
Dipole moment: 1.79 [033]
pKa1: 4.88; pKa2: 1.89 (20 C, H2O) [029]
Refractive index: 1.6339 @ 58 C [016,395]
log P oct 0.00/0.03 (calculated) [055]
Specific gravity: 1.139 @ 15/15 C [205]
Density: 1.10 g/mL @ 75 C, 1.08 g/mL @ 100 C [058]
Vapor pressure: 5 mm Hg @ 131.2 C, 10 mm Hg @ 147.0 C, 20 mm Hg @ 163.8 C, 40
mm Hg @ 182.5 C, 60 mm Hg @ 194.0 C, 100 mm Hg @ 209.9 C, 200 mm Hg @ 233.0 C,
400 mm Hg @ 259.0 C, 760 mm Hg @ 285.5 C [038]; 0.6224 mm Hg @ 100 C [058]
Boiling point: 135-140 C @ 5 mm Hg [029]
pH 8.4 (269 g/L water @ 24 C) [058]
Evaporation rate (butyl acetate = 1): <1 [058]
100% volatile by volume [058]
Lambda max (in cyclohexane): 240 nm, 293 nm (Epsilon = 708, 263) [395]
Slight aromatic odor [058]
TOXICITY
NIOSH REGISTRY NUMBER: SS7700000
TOXICITY:
typ. dose mode specie amount unit other
LDLo orl cat 300 mg/kg
LD50 unr rat 351 mg/kg
LD50 ipr rat 283 mg/kg
LDLo scu rat 30 mg/kg
LD50 unr mus 65300 ug/kg
LDLo orl rbt 300 mg/kg
LDLo skn rbt 5000 mg/kg
LDLo scu rbt 200 mg/kg
LDLo ivn dog 17 mg/kg
LDLo ipr mus 400 mg/kg
LD50 unr rbt 438 mg/kg
LD50 unr gpg 450 mg/kg
LD50 orl bwd 562 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion, intravenous, subcutaneous, intraperitoneal and
possibly other routes. Mildly toxic by skin contact. An experimental
tumorigen and teratogen. Mutagenic data.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: scu-rat 1485 mg/kg/47W-I
Review: IARC Cancer Review; Animal Inadequate Evidence
IARC: Not classifiable as human carcinogen (Group 3) [015,395,610]
MUTATION DATA: See RTECS printout for data
TERATOGENICITY: See RTECS printout for data
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
OTHER TOXICITY DATA:
Standards and Regulations: DOT-Hazard: ORM-A; Label: None
DOT-IMO: Poison B; Label: St. Andrew's Cross
Status: EPA TSCA Chemical Inventory, 1989
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
EPA TSCA Test Submission (TSCATS) Data Base, April 1990
EPA TSCA Section 8(e) Status Report 8EHQ-1285-0577
EPA Genetox Program 1988, Positive: SHE-clonal assay; Histidine
reversion-Ames test
EPA Genetox Program 1988, Inconclusive: Rodent dominant lethal
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Phenylenediamines
UN/ID NUMBER: UN1673
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III
LABELS REQUIRED: Keep away from food
PACKAGING: PASSENGER: PKG. INSTR.: 619, Y619 MAXIMUM QUANTITY: 100 kg, 10 kg
CARGO : PKG. INSTR.: 619 MAXIMUM QUANTITY: 200 kg
SPECIAL PROVISIONS: None
USES:
This compound is used in dyestuff manufacture and photography, in the
detection of nitrite and in textile developing agents, laboratory reagents,
vulcanizing agents, ion-exchange resins, block polymers and corrosion
inhibitors. It is also used in rubber curing agents, decoloring resins,
formaldehyde condensates, resinous polyamides, textile fibers, urethanes,
petroleum additives, rubber chemicals and reagents for gold and bromine. This
compound is also used as a hair dye ingredient and as a curing agent for epoxy
resins.
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound is harmful if inhaled, swallowed or absorbed through the
skin [036,062,269]. It causes irritation of the eyes, skin, mucous membrane
and respiratory tract [269]. When heated to decomposition, this compound emits
irritating and/or toxic gases and fumes of carbon monoxide, carbon dioxide and
oxides of nitrogen [043,058,269].
MINIMUM PROTECTIVE CLOTHING: Not available
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-161 0.40 mm 480 min
Neoprene Pioneer N-44 0.56 mm 480 min
Viton/Neoprene MSA Valutex 0.58 mm 480 min
PVA Edmont 25-950 0.33 mm 480 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should protect this chemical from exposure to light. Keep
the container tightly closed under an inert atmosphere, and store
under refrigerated temperatures.
SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this chemical may include skin sensitization
reactions, eye irritation and injury, skin irritation, dermatitis, blackened
skin and bronchial asthma [036]. Other symptoms may include allergic skin
reactions, irritation of the mucous membranes, nose, throat and lungs, cough-
ing, burning sensation, runny nose, sore throat, methemoglobinemia, cyanosis,
headache, dizziness, drowsiness, mental confusion, pulmonary edema, kidney and
liver damage, central nervous system effects and conjunctivitis. Eye contact
may cause discomfort, tearing, blurring of vision, reddening, partial clouding
of the cornea and swelling of the eye and surrounding tissue [058]. Dysuria
and eosinophiluria may also occur [395]. Exposure may also result in
respiratory tract irritation [269].
SOURCES
SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. SS7700000.
May 4, 1990.
[016] Weast, R.C., D.R. Lide, M.J. Astle, and W.H. Beyer, Eds. CRC Handbook
of Chemistry and Physics. 70th Ed. CRC Press, Inc. Boca Raton,
FL. 1989. p. C-110, #2062.
[029] Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed. and
Supplements. Chapman and Hall. New York. 1988. Vol. 2, p. 1529,
#D-00626.
[033] Budavari, Susan, Ed. The Merck Index. 11th Ed. Merck and Co., Inc.
Rahway, NJ. 1989. p. 1157, #7254.
[036] Bretherick, L., Ed. Hazards in the Chemical Laboratory. 4th Ed.
The Royal Society of Chemistry. London. 1986. p. 450.
[038] Stull, D.R. Vapor pressure of pure substances: Organic Compounds.
Industrial and Engineering Chem. 39(4):517-550. 1947. Listed.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. III, p. 2737, #PEY000.
[055] Verschueren, K. Handbook of Environmental Data on Organic
Chemicals. 2nd Ed. Van Nostrand Reinhold. New York. 1983.
pp. 988-989.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. April/May 1990.
#2221-032, B-05; #5833-837, B-09.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 901.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[105] The Society of Dyers and Colourists. Colour Index. Vols. 1-8.
The Society of Dyers and Colourists. Yorkshire, England.
American Association of Textile Chemists and Colorists.
Research Triangle Park, NC. 1971-1987. Vol. 2, p. 2002; Vol. 4,
p. 4820.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Not listed.
[195] Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds. CFTA Cosmetic
Ingredient Dictionary. 3rd Ed and Supplement. The Cosmetic,
Toiletry and Fragrance Assn. Inc. Washington. 1982. p. 232.
[205] Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed.
McGraw-Hill Book Company. New York. 1985. p. 7-588, #p218.
[269] Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data.
Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985.
p. 1465, #D.
[275] Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine
Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI.
1988. p. 1200, #P2,395-4.
[395] International Agency for Research on Cancer, World Health
Organization. IARC Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man. International
Agency for Research on Cancer. Geneva. Vol. 16, pp. 111-124;
Supplement 7, p. 70.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Update, p. xxviii.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
-------------------------------------------------------------