NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991)
IDENTIFIERS
CATALOG ID NUMBER: 000058
CAS NUMBER: 108-39-4
BASE CHEMICAL NAME: CRESOL,M-
PRIMARY NAME: M-CRESOL
CHEMICAL FORMULA: C7H8O
STRUCTURAL FORMULA: CH3C6H4OH
WLN: QR C1
SYNONYMS:
3-CRESOL
3-HYDROXYTOLUENE
M-CRESYLIC ACID
M-METHYLPHENOL
3-METHYLPHENOL
1-HYDROXY-3-METHYLBENZENE
M-OXYTOLUENE
M-CRESOLE
M-HYDROXYTOLUENE
M-KRESOL
RCRA WASTE NUMBER U052
M-TOLUOL
UN 2076
PHYSICAL CHEMICAL DATA
PHYSICAL DESCRIPTION: LITERATURE: Colorless to yellowish liquid
REPOSITORY: Clear, light yellow, viscous liquid
MOLECULAR WEIGHT: 108.14
SPECIFIC GRAVITY: 1.034 @ 20/4 C [031,043,051,205]
DENSITY: 1.0336 g/mL @ 20 C [371]
MP (DEG C): 11.5 C [016,047,058,371]
BP (DEG C): 203 C [062,269,275,371]
SOLUBILITIES:
WATER : 10-50 mg/mL @ 20 C (RAD)
DMSO : >=100 mg/mL @ 20 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 20 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Ether: Soluble [016,047,062]
Benzene: Soluble [016,047]
Organic solvents: Soluble [295,455]
Solutions of fixed alkali hydroxides: Soluble [031]
Chloroform: Miscible [031,205]
Dilute alkalies: Soluble [205,421]
Mineral oil: 2.5% [430]
Glycol: Soluble [421]
Alcohol: Soluble [016,062,421]
VOLATILITY:
Vapor pressure: 0.04 mm Hg @ 20 C [055]; 1 mm Hg @ 52 C [038,043,051]
Vapor density : 3.72 [043,051,055,072]
FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 86 C (187 F) [031,062,205,275]. It is
combustible. Fires involving this material can be controlled with a dry
chemical, carbon dioxide or Halon extinguisher. A water spray may also be used
[051,058,371,451]. The autoignition temperature of this compound is 558 C
(1038 F) [043,062,371,451].
UEL: 1.35% [051,072,371] LEL: 1.06% [051,072,371]
REACTIVITY:
This chemical can react vigorously with strong oxidizers and strong bases
[058,102,269]. It reacts violently with nitric acid, oleum, chlorosulfonic
acid, metals and strong acids. If the water content is below approximately
0.3% and the temperature above 120 C, the corrosion of aluminum and its alloys
may occur violently [058]. It will attack some forms of plastics, coatings and
rubber [102].
STABILITY:
This chemical is sensitive to air, light and heat. It is also hygro-
scopic [269].
OTHER PHYSICAL DATA:
Phenolic odor [031,036,062,102]
Boiling point: 86 C @ 10 mm Hg [016,047]
Boiling point: 80 C @ 6 mm Hg [025]
Specific gravity: 1.04 @ 22/4 C [025]
Vapor pressure: 5 mm Hg @ 76.0 C; 10 mm Hg @ 87.8 C [038]
Steam-volatile [025]
log P octanol: 1.96/2.01 [055]
Refractive index: 1.5438 @ 20 C [016,047,205]
Critical temperature: 432 C [371]
Critical pressure: 45.0 atmospheres [371]
Percent volatile by volume: 100% [058]
pH: 5.5 [058]
Odor threshold: 5 ppm [058]
Taste threshold: 0.002 ppm [051,072]
Pungent taste [295]
Sinks and mixes with water [371]
Liquid surface tension: 41.7 dynes/cm @ 20 C [371]
Liquid water interfacial tension: 31.3 dynes/cm @ 20 C [371]
Ratio of specific heats of vapor (gas): 1-1.05 (estimated) [371]
Latent heat of vaporization: 100.6 cal/g [371]
Heat of combustion: -7798 cal/g [371]
Saturation concentration: 0.24 g/m3 @ 20 C, 0.68 g/m3 @ 30 C [055]
Evaporation rate (butyl acetate = 1): 0.015 [102]
TOXICITY
NIOSH REGISTRY NUMBER: GO6125000
TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 242 mg/kg
LD50 skn rat 1100 mg/kg
LDLo scu rat 900 mg/kg
LD50 orl mus 828 mg/kg
LD50 ipr mus 168 mg/kg
LDLo scu mus 450 mg/kg
LD50 unr mus 600 mg/kg
LDLo ivn dog 150 mg/kg
LDLo scu cat 180 mg/kg
LDLo orl rbt 1400 mg/kg
LD50 skn rbt 2050 mg/kg
LDLo scu rbt 500 mg/kg
LDLo ivn rbt 280 mg/kg
LDLo ipr gpg 100 mg/kg
LDLo scu gpg 300 mg/kg
LDLo scu frg 250 mg/kg
AQTX/TLM96: Not available
SAX TOXICITY EVALUATION:
THR: Poison by ingestion, intravenous, intraperitoneal and subcutaneous
routes. Moderately toxic by skin contact. An experimental neoplastigen.
Severe eye and skin irritant. Human mutagenic data.
CARCINOGENICITY:
Tumorigenic Data:
TDLo: skn-mus 2280 mg/kg/20W-I
MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
dni-hmn:hla 10 umol/L/4H |
TERATOGENICITY:
Reproductive Effects Data:
TDLo: scu-rbt 134 gm/kg (6-18D preg)
STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
Transitional Limit: PEL-TWA 5 ppm (skin) [015,327,545,610]
Final Limit: PEL-TWA 5 ppm (skin) [015,545,610]
ACGIH: TLV-TWA 5 ppm (skin) [415,421,610]
NIOSH Criteria Document: Recommended exposure limit to this compound-air:
TWA 2.3 ppm/10H [015,610]
NFPA Hazard Rating: Health (H): 3
Flammability (F): 1
Reactivity (R): 0
H3: Materials extremely hazardous to health but areas may be entered
with extreme care (see NFPA for details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
OTHER TOXICITY DATA:
Skin and Eye Irritation Data:
skn-rbt 517 mg/24H SEV
eye-rbt 103 mg SEV
Review: Toxicology Review
Standards and Regulations: DOT-IMO: Poison B; Label: Poison
Status: EPA TSCA Chemical Inventory, 1986
EPA TSCA 8(a) Preliminary Assessment Information, Final Rule
EPA TSCA Test Submission (TSCATS) Data Base, January 1989
NIOSH Analytical Methods: see Cresols, 2001
Meets criteria for proposed OSHA Medical Records Rule
IDLH value: 250 ppm [371]
Fatal dose: 2 g [301]
OTHER DATA (Regulatory)
PROPER SHIPPING NAME (IATA): Cresols
UN/ID NUMBER: UN2076
HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: II
LABELS REQUIRED: Poison
PACKAGING: PASSENGER: PKG. INSTR.: 609, Y609 MAXIMUM QUANTITY: 5 L, 1 L
CARGO : PKG. INSTR.: 611 MAXIMUM QUANTITY: 60 L
SPECIAL PROVISIONS: None
USES:
This compound is used in disinfectants, in resins, as a raw material
for photographic developers, in ore flotation, in fumigation compounds, in
explosives, in phenol, as an insecticide, as a wood preservative, in degreasing
compounds, in paintbrush cleaners and as an additive to lubricating oils. It
is also used as an intermediate in the manufacture of chemicals, dyes, plastics
and antioxidants. It is used in the manufacture of antiseptics, phosphate
esters, herbicides and perfumes, as a solvent, as an engine and metal cleaner
and in the textile industry.
COMMENTS:
This compound is obtained from coal tar [031,062].
HANDLING PROCEDURES
ACUTE/CHRONIC HAZARDS:
This compound may be fatal if ingested or absorbed through the skin. It
causes burns and is readily absorbed through the skin [269]. It is corrosive
[036,058,295,346]. When heated to decomposition it emits toxic fumes of carbon
monoxide and formaldehyde [102].
MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-174 0.43 mm 480 min
Viton North F-091 0.23 mm 480 min
Neoprene Edmont 29-870 0.46 mm 180 min
RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
OTHER: Not available
STORAGE PRECAUTIONS:
You should protect this chemical from exposure to light. Keep
the container tightly closed under an inert atmosphere, and store
under refrigerated temperatures.
SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
DISPOSAL AND WASTE TREATMENT: Not available
EMERGENCY PROCEDURES
SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
INGESTION:
DO NOT INDUCE VOMITING. Phenols are very toxic poisons AND corrosive
and irritating, so that inducing vomiting may make medical problems worse.
IMMEDIATELY call a hospital or poison control center and locate activated
charcoal, egg whites, or milk in case the medical advisor recommends admini-
stering one of them.
If advice from a physician is not readily available and the victim is
conscious and not convulsing, give the victim a glass of activated charcoal
slurry in water or, if this is not available, a glass of milk, or beaten egg
whites and IMMEDIATELY transport victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth,
assure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
SYMPTOMS:
Symptoms of exposure to this compound via skin contact include prickling,
intensive burning and loss of feeling. The affected skin may be wrinkled,
white, discolored and softened. Later, gangrene may occur. Repeated or pro-
longed exposure may cause a rash [346]. Eye contact may cause burning, tear-
ing, reddening, swelling of the eyes and surrounding tissue and, in some cases,
blindness. It may cause irritation of the nose and throat, sleeplessness,
damage to the lungs, liver, kidneys, blood, nervous system and respiratory
system; corrosion of the skin and eyes, skin sensitization, weak pulse, tin-
nitus, emphysema, edema, congestion in the brain, dermatitis, disturbances of
the gastrointestinal and vascular systems, difficulty in swallowing, saliva-
tion, loss of appetite, fainting, dizziness, anorexia, hypertension, slightly
enlarged heart, facial muscle spasms and tremors [058]. Systemic poisoning
results in weakness of the muscles, headache, dimness of vision, rapid breath-
ing, mental confusion, unconsciousness and death [346]. It can also cause
respiratory system irritation, nausea, vomiting, stomach pains, exhaustion and
possibly coma [036]. It can also cause hemorrhages, destruction of cellular
protoplasm of the gastroenteric tract and bronchopneumonia with petechial
hemorrhages in the pleura [430]. Optic atrophy and opacification may occur
[099]. It may cause a burning sensation in the mouth and esophagus, corneal
damage, gastroenteric disturbances, severe depression, collapse and injury of
the spleen and pancreas [371]. Allergic reactions have also been reported
[051].
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